DMD Celsis microsomes equal better data

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N-depyridination and N-dedimethylaminoethylation of tripelennamine and pyrilamine in the rat. New metabolic pathways

SY Yeh

National Institute on Drug Abuse, Addiction Research Center, Baltimore, MD 21224.

N-(2-Dimethylaminoethyl)benzylamine and 2-benzylaminopyridine were identified as two new urinary metabolites of tripelennamine in the rat by GC/MS. 2-(4-Methoxybenzylamino)-pyridine and N-(dimethylaminoethyl)- 4-hydroxybenzylamine were identified as new urinary metabolites of pyrilamine by GC/MS. Thus, in addition to N- and O-demethylation, hydroxylation, and glucuronidation, N-debenzylation, N-depyridination and N-dedimethylaminoethylation were shown to be novel pathways for metabolism of tripelennamine and pyrilamine. The mechanism for N- depyridination and N-dealkylation is discussed.

Volume 18, Issue 4, pp. 453-461, 07/01/1990
Copyright © 1990 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1990 by the American Society for Pharmacology and Experimental Therapeutics.