![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
C Pous, JP Giroud, C Damais, D Raichvarg and L Chauvelot-Moachon
Departement de Pharmacologie, CNRS-URA 595, Hopital Cochin, Paris, France.
Two hepatocyte-related effects of recombinant human interleukin-1 beta and tumor necrosis factor alpha alone or in association were tested following iv administration to Fischer 344 rats. Within 24 hr, both monokines induced a dose-dependent decrease in cytochrome P-450 levels, whereas serum alpha-1-acid glycoprotein concentrations were strongly increased. The largest variation of both parameters was observed using a combination of the two monokines. Dexamethasone, which possesses anti- interleukin-1 properties and is known to stimulate alpha-1-acid glycoprotein synthesis in rats, also depressed cytochrome P-450 levels, suggesting that alpha-1-acid glycoprotein might mediate the monokine- related inhibition of drug metabolism. Nevertheless, at the lowest doses of monokines tested, only cytochrome P-450 levels were modified. The transfer of a post-dexamethasone serum to normal rats did not change cytochrome P-450 levels.
This article has been cited by other articles:
|
|
 |
|
  D. Y. Hung, G. A. Siebert, P. Chang, M. W. Whitehouse, L. Fletcher, D. H. G. Crawford, and M. S. Roberts Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G343 - G351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Li and C. D. Klaassen Lipopolysaccharide-Induced Down-Regulation of Organic Anion Transporting Polypeptide 4 (Oatp4; Slc21a10) Is Independent of Tumor Necrosis Factor-{alpha}, Interleukin-1{beta}, Interleukin-6, or Inducible Nitric Oxide Synthase Toxicol. Sci., January 1, 2005; 83(1): 197 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Luyendyk, K. C. Shores, P. E. Ganey, and R. A. Roth Bacterial Lipopolysaccharide Exposure Alters Aflatoxin B1 Hepatotoxicity: Benchmark Dose Analysis for Markers of Liver Injury Toxicol. Sci., July 1, 2002; 68(1): 220 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Barton, P. E. Ganey, and R. A. Roth Lipopolysaccharide Augments Aflatoxin B1-Induced Liver Injury through Neutrophil-Dependent and -Independent Mechanisms Toxicol. Sci., November 1, 2000; 58(1): 208 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. W. Warren, S. M. Poloyac, D. S. Gary, M. P. Mattson, and R. A. Blouin Hepatic Cytochrome P-450 Expression in Tumor Necrosis Factor-alpha Receptor (p55/p75) Knockout Mice After Endotoxin Administration J. Pharmacol. Exp. Ther., March 1, 1999; 288(3): 945 - 950. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. J. Meunier and R. K. Verbeeck Glucuronidation of R- and S-Ketoprofen, Acetaminophen, and Diflunisal by Liver Microsomes of Adjuvant-Induced Arthritic Rats Drug Metab. Dispos., January 1, 1999; 27(1): 26 - 31. [Abstract] [Full Text]
|
|
 |
 |
 |
|
 |
 |
 |
