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Metabolism of the carcinogen 3-methylcholanthrene in human bone marrow preparations

SR Myers and JW Flesher

Department of Pharmacology, University of Kentucky.

The metabolism of 3-methylcholanthrene was investigated by incubating the hydrocarbon with human bone marrow preparations in air for 60 min at 37 degrees C. The major metabolites were identified by HPLC and GC/MS as 1-hydroxy-3-methylcholanthrene, 1-keto-3-methylcholanthrene, and cholanthrene. The results demonstrate that the potent carcinogen, 3- methylcholanthrene, can undergo biochemical reactions in preparations of human bone marrow, giving rise to the formation of metabolites which are known to be carcinogenic in rats and mice.

Volume 18, Issue 5, pp. 664-669, 09/01/1990
Copyright © 1990 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1990 by the American Society for Pharmacology and Experimental Therapeutics.