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Metabolism of 1,1-dichloro-cis-diphenylcyclopropane by rat liver microsomes

O Caputo, G Grosa, M Ceruti, F Rocco and G Biglino

Istituto di Chimica Farmaceutica Applicata, Universita di Torino, Italia.

The metabolic fate of the anti-estrogen 1,1-dichloro-cis- diphenylcyclopropane (Analog II), was studied in vitro with phenobarbital-induced rat liver microsomal fractions. The presence of five metabolites was directly or indirectly established. Biotransformation products were isolated by TLC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The presence of an allyl chloride, highly reactive, metabolic intermediate was stated.

Volume 18, Issue 5, pp. 771-778, 09/01/1990
Copyright © 1990 by American Society for Pharmacology and Experimental Therapeutics






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Copyright © 1990 by the American Society for Pharmacology and Experimental Therapeutics.