DMD Noab BioDiscoveries - Shaping Drug Discovery

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May 1988; 16 (3)   [Index by Author]       Other Issues:  
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Articles:

TW Shih, YF Shealy, and DL Hill
Enzymatic hydrolysis of retinamides
Drug Metab Dispos 1988 16: 337-340. [Abstract] [PDF]  

DW Hein, A Trinidad, T Yerokun, RJ Ferguson, WG Kirlin, and WW Weber
Genetic control of acetyl coenzyme A-dependent arylamine N- acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy- arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse
Drug Metab Dispos 1988 16: 341-347. [Abstract] [PDF]  

RE Galinsky and GB Corcoran
Suppression of acetaminophen conjugation and of conjugate elimination in the rat by metyrapone, a classical P-450 inhibitor
Drug Metab Dispos 1988 16: 348-354. [Abstract] [PDF]  

T Yamamoto, WM Jr Pierce, HE Hurst, D Chen, and WJ Waddell
Inhibition of the metabolism of urethane by ethanol
Drug Metab Dispos 1988 16: 355-358. [Abstract] [PDF]  

K Straub, M Davis, and B Hwang
Benzazepine metabolism revisited. Evidence for the formation of novel amine conjugates
Drug Metab Dispos 1988 16: 359-366. [Abstract] [PDF]  

CT Gombar, RM Demarinis, M Wise, and BA Mico
Pharmacokinetics of a series of 6-chloro-2,3,4,5-tetrahydro-3- substituted-1H- 3-benzazepines in rats. Determination of quantitative structure-pharmacokinetic relationships
Drug Metab Dispos 1988 16: 367-372. [Abstract] [PDF]  

R Chen and JR Gillette
Pharmacokinetic procedures for the estimation of organ clearances for the formation of short-lived metabolites. Acetaminophen-induced glutathione depletion in hamster liver
Drug Metab Dispos 1988 16: 373-385. [Abstract] [PDF]  

DJ Gole, JL Pirat, JM Kamenka, and EF Domino
Hydroxy metabolites of phencyclidine. Identification and quantitation of two novel metabolites
Drug Metab Dispos 1988 16: 386-391. [Abstract] [PDF]  

JH Lin, IW Chen, EH Ulm, and DE Duggan
Differential renal handling of angiotensin-converting enzyme inhibitors enalaprilat and lisinopril in rats
Drug Metab Dispos 1988 16: 392-396. [Abstract] [PDF]  

MK Shigenaga, AJ Trevor, and N Jr Castagnoli
Metabolism-dependent covalent binding of (S)-[5-3H]nicotine to liver and lung microsomal macromolecules
Drug Metab Dispos 1988 16: 397-402. [Abstract] [PDF]  

W Meuldermans, A Van Peer, J Hendrickx, W Lauwers, E Swysen, M Bockx, R Woestenborghs, and J Heykants
Excretion and biotransformation of cisapride in dogs and humans after oral administration
Drug Metab Dispos 1988 16: 403-409. [Abstract] [PDF]  

W Meuldermans, J Hendrickx, W Lauwers, R Hurkmans, E Mostmans, E Swysen, J Bracke, A Knaeps, and J Heykants
Excretion and biotransformation of cisapride in rats after oral administration
Drug Metab Dispos 1988 16: 410-419. [Abstract] [PDF]  

LA Dostal, C Guthenberg, B Mannervik, and JR Bend
Stereoselectivity and regioselectivity of purified human glutathione transferases pi, alpha-epsilon, and mu with alkene and polycyclic arene oxide substrates
Drug Metab Dispos 1988 16: 420-424. [Abstract] [PDF]  

CY Quon, K Mai, G Patil, and HF Stampfli
Species differences in the stereoselective hydrolysis of esmolol by blood esterases
Drug Metab Dispos 1988 16: 425-428. [Abstract] [PDF]  

JM Sanders, LT Burka, and HB Matthews
Metabolism and disposition of n-butyl acrylate in male Fischer rats
Drug Metab Dispos 1988 16: 429-434. [Abstract] [PDF]  

YM Ioannou, JM Sanders, and HB Matthews
Methyl carbamate. Species-dependent variations in metabolism and clearance in rats and mice
Drug Metab Dispos 1988 16: 435-440. [Abstract] [PDF]  

WG Levine and H Raza
Mechanism of azoreduction of dimethylaminoazobenzene by rat liver NADPH- cytochrome P-450 reductase and partially purified cytochrome P-450. Oxygen and carbon monoxide sensitivity and stimulation by FAD and FMN
Drug Metab Dispos 1988 16: 441-448. [Abstract] [PDF]  

P Srinivas and LT Burka
Metabolism of 1-chloro-2-methylpropene. Evidence for reactive chloroaldehyde intermediates
Drug Metab Dispos 1988 16: 449-454. [Abstract] [PDF]  

RM Maiorino, GL Weber, and HV Aposhian
Determination and metabolism of dithiol chelating agents. III. Formation of oxidized metabolites of 2,3-dimercaptopropane-1-sulfonic acid in rabbit
Drug Metab Dispos 1988 16: 455-463. [Abstract] [PDF]  

DW Clark, GN Smith, J Patrick, B Richardson, and JF Brien
Disposition of ethanol and its proximate metabolite, acetaldehyde, in the near-term pregnant ewe for short term maternal administration of moderate-dose ethanol
Drug Metab Dispos 1988 16: 464-468. [Abstract] [PDF]  

E Samara, M Bialer, and R Mechoulam
Pharmacokinetics of cannabidiol in dogs
Drug Metab Dispos 1988 16: 469-472. [Abstract] [PDF]  

P Zanoli, A Benelli, M Sandrini, and M Baraldi
Distribution of [3H]colchicine in brain and spinal cord areas following its intracerebroventricular or intra-spinal cord injection in rats
Drug Metab Dispos 1988 16: 473-476. [Abstract] [PDF]  

FA Posadas del Rio, F Jaramillo Juarez, and R Camacho Garcia
Biotransformation of organic nitrate esters in vitro by human liver, kidney, intestine, and blood serum
Drug Metab Dispos 1988 16: 477-481. [Abstract] [PDF]  

SC Tsao, Y Sugiyama, K Shinmura, Y Sawada, S Nagase, T Iga, and M Hanano
Protein-mediated hepatic uptake of rose bengal in analbuminemic mutant rats (NAR). Albumin is not indispensable to the protein-mediated transport of rose bengal
Drug Metab Dispos 1988 16: 482-489. [Abstract] [PDF]  

B Baier-Weber, A Prox, H Wachsmuth, and U Breyer-Pfaff
Glucuronides of hydroxylated metabolites of amitriptyline and nortriptyline isolated from rat bile
Drug Metab Dispos 1988 16: 490-496. [Abstract] [PDF]  

FL Tse and HT Smith
Influence of a platelet-activating factor antagonist on circulating levels of cyclosporine in the dog
Drug Metab Dispos 1988 16: 497-498. [PDF]  

SY Yeh and FL Hsu
Quantitative metabolic profile of tripelennamine and pyrilamine in the rat
Drug Metab Dispos 1988 16: 499-502. [PDF]  

PH Hsyu, FM Wong, and KM Giacomini
The effect of pindolol on the transport of L-lysine in renal brush border membrane vesicles
Drug Metab Dispos 1988 16: 503-505. [PDF]  

AK Chaudhary, JW Hubbard, G McKay, and KK Midha
Identification of a quaternary ammonium-linked glucuronide of chlorpromazine in the urine of a schizophrenic patient treated with chlorpromazine
Drug Metab Dispos 1988 16: 506-508. [PDF]  

E Nusser, K Nill, and U Breyer-Pfaff
Enantioselective formation and disposition of (E)- and (Z)-10- hydroxynortriptyline
Drug Metab Dispos 1988 16: 509-511. [PDF]  

EN Maduagwu
Intervention of nitrite in the metabolism of quaternary ammonium compounds
Drug Metab Dispos 1988 16: 512-514. [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


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