DMD Noab BioDiscoveries - Shaping Drug Discovery

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March 1989; 17 (2)   [Index by Author]       Other Issues:  
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To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

WC Kershaw, DA Barsotti, TB Leonard, JG Dent, and GL Lage
Methoxyflurane enhances allyl alcohol hepatotoxicity in rats. Possible involvement of increased acrolein formation
Drug Metab Dispos 1989 17: 117-122. [Abstract] [PDF]  

DJ Porubek, MP Grillo, and TA Baillie
The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes
Drug Metab Dispos 1989 17: 123-130. [Abstract] [PDF]  

HM Carpenter and LR Curtis
A characterization of chlordecone pretreatment-altered pharmacokinetics in mice
Drug Metab Dispos 1989 17: 131-138. [Abstract] [PDF]  

JB Tarloff, RS Goldstein, BA Mico, and JB Hook
Role of pharmacokinetics and metabolism in the enhanced susceptibility of middle-aged male Sprague-Dawley rats to acetaminophen nephrotoxicity
Drug Metab Dispos 1989 17: 139-146. [Abstract] [PDF]  

JH Lin, FA DeLuna, DJ Tocco, and EH Ulm
Effect of experimental diabetes on elimination kinetics of diflunisal in rats [see comments]
Drug Metab Dispos 1989 17: 147-152. [Abstract] [PDF]  

AR Jeffcoat, M Perez-Reyes, JM Hill, BM Sadler, and CE Cook
Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking
Drug Metab Dispos 1989 17: 153-159. [Abstract] [PDF]  

FF Vickers, TA Bowman, BH Dvorchik, GT Passananti, DM Hughes, and ES Vesell
On the antipyrine test in laboratory animals. Studies in the dog and monkey
Drug Metab Dispos 1989 17: 160-165. [Abstract] [PDF]  

DE Duggan, IW Chen, WF Bayne, RA Halpin, CA Duncan, MS Schwartz, RJ Stubbs, and S Vickers
The physiological disposition of lovastatin
Drug Metab Dispos 1989 17: 166-173. [Abstract] [PDF]  

JF Newton, LP Yodis, D Keohane, R Eckardt, R Dewey, J Dent, and B Mico
Pharmacokinetics and metabolism of SK&F 86002 in male and female Sprague-Dawley rats
Drug Metab Dispos 1989 17: 174-179. [Abstract] [PDF]  

CS Godin and PA Crooks
N-methylation as a toxication route for xenobiotics. II. In vivo formation of N,N'-dimethyl-4,4'-bipyridyl ion (paraquat) from 4,4'- bipyridyl in the guinea pig
Drug Metab Dispos 1989 17: 180-185. [Abstract] [PDF]  

NL Flowers, JP O'Donnell, and HD Colby
Spironolactone metabolism in target tissues. Characteristics of deacetylation in kidney, liver, adrenal cortex, and testes
Drug Metab Dispos 1989 17: 186-189. [Abstract] [PDF]  

AA Somogyi, CM Hovens, MR Muirhead, and F Bochner
Renal tubular secretion of amiloride and its inhibition by cimetidine in humans and in an animal model
Drug Metab Dispos 1989 17: 190-196. [Abstract] [PDF]  

J Combalbert, I Fabre, G Fabre, I Dalet, J Derancourt, JP Cano, and P Maurel
Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily
Drug Metab Dispos 1989 17: 197-207. [Abstract] [PDF]  

DA Joyce, DN Wade, and BR Swanson
The pharmacokinetics of albumin conjugates of D-penicillamine in rats
Drug Metab Dispos 1989 17: 208-211. [Abstract] [PDF]  

WH Lim and WD Hooper
Stereoselective metabolism and pharmacokinetics of racemic methylphenobarbital in humans
Drug Metab Dispos 1989 17: 212-217. [Abstract] [PDF]  

A Wahlstrom, K Persson, and A Rane
Metabolic interaction between morphine and naloxone in human liver. A common pathway of glucuronidation?
Drug Metab Dispos 1989 17: 218-220. [Abstract] [PDF]  

JH Lin
Species differences in protein binding of diflunisal
Drug Metab Dispos 1989 17: 221-223. [PDF]  

MC Nishimura, P 3d Jacob, ME Cassel, and LH Pitts
Tissue distribution of intravenously administered dimethyl sulfoxide in the normal rat
Drug Metab Dispos 1989 17: 224-226. [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


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