Articles:

MJ Juedes and D Kupfer

Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrene- treated rats
Drug Metab Dispos 1990 18: 131-137. [Abstract] [PDF]  

S Vickers, CA Duncan, IW Chen, A Rosegay, and DE Duggan

Metabolic disposition studies on simvastatin, a cholesterol-lowering prodrug
Drug Metab Dispos 1990 18: 138-145. [Abstract] [PDF]  

HG Oldham, P Standring, SJ Norman, TJ Blake, I Beattie, PJ Cox, and RJ Chenery

Metabolism of temelastine (SK&F 93944) in hepatocytes from rat, dog, cynomolgus monkey and man
Drug Metab Dispos 1990 18: 146-152. [Abstract] [PDF]  

JW Russell, VJ Whiterock, D Marrero, and LJ Klunk

Disposition in animals of a new anti-HIV agent: 2',3'-didehydro-3'- deoxythymidine
Drug Metab Dispos 1990 18: 153-157. [Abstract] [PDF]  

DR Luke, LJ Brunner, and K Vadiei

Bioavailability assessment of cyclosporine in the rat. Influence of route of administration
Drug Metab Dispos 1990 18: 158-162. [Abstract] [PDF]  

JW Flesher and SR Myers

Bioalkylation of benz[a]anthracene as a biochemical probe for carcinogenic activity. Lack of bioalkylation in a series of six noncarcinogenic polynuclear aromatic hydrocarbons
Drug Metab Dispos 1990 18: 163-167. [Abstract] [PDF]  

J Halpert, JY Jaw, C Balfour, and LS Kaminsky

Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form(s) of rat liver cytochrome P-450
Drug Metab Dispos 1990 18: 168-174. [Abstract] [PDF]  

TA Hultin, MS Filla, and DL McCormick

Distribution and metabolism of the retinoid, N-(4-methoxyphenyl)-all- trans-retinamide, the major metabolite of N-(4-hydroxyphenyl)-all-trans- retinamide, in female mice
Drug Metab Dispos 1990 18: 175-179. [Abstract] [PDF]  

SC Tsao, TH Dickinson, and DR Abernethy

Metabolite inhibition of parent drug biotransformation. Studies of diltiazem
Drug Metab Dispos 1990 18: 180-182. [Abstract] [PDF]  

M Buonarati, AD Jones, and A Buckpitt

In vivo metabolism of isomeric naphthalene oxide glutathione conjugates
Drug Metab Dispos 1990 18: 183-189. [Abstract] [PDF]  

S Capello, L Henderson, F DeGrazia, D Liberato, W Garland, and C Town

The effect of the cytochrome P-450 suicide inactivator, 1- aminobenzotriazole, on the in vivo metabolism and pharmacologic activity of flurazepam
Drug Metab Dispos 1990 18: 190-196. [Abstract] [PDF]  

GM Pollack, KL Brouwer, KB Demby, and JA Jones

Determination of hepatic blood flow in the rat using sequential infusions of indocyanine green or galactose
Drug Metab Dispos 1990 18: 197-202. [Abstract] [PDF]  

KP Vyas, PH Kari, SM Pitzenberger, RA Halpin, HG Ramjit, B Arison, JS Murphy, WF Hoffman, MS Schwartz, and EH Ulm

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse
Drug Metab Dispos 1990 18: 203-211. [Abstract] [PDF]  

M Yoshikawa, H Endo, K Komatsu, M Fujihara, O Takaiti, T Kagoshima, M Umehara, and H Ishikawa

Disposition of a new orally active dopamine prodrug, N-(N-acetyl-L- methionyl)-O,O-bis(ethoxycarbonyl) dopamine (TA-870) in humans
Drug Metab Dispos 1990 18: 212-217. [Abstract] [PDF]  

KP Vyas, PH Kari, SR Prakash, and DE Duggan

Biotransformation of lovastatin. II. In vitro metabolism by rat and mouse liver microsomes and involvement of cytochrome P-450 in dehydrogenation of lovastatin
Drug Metab Dispos 1990 18: 218-222. [Abstract] [PDF]  

VA Tutelyan, LV Kravchenko, and EE Kuzmina

The effect of aspartame on the activity of rat liver xenobiotic- metabolizing enzymes
Drug Metab Dispos 1990 18: 223-225. [Abstract] [PDF]  

K Copeland, M Lukowski, R Yatscoff, J Thliveris, and N Honcharik

Pharmacokinetics and biotransformation of the cyclosporine metabolite M- 17 in the rabbit
Drug Metab Dispos 1990 18: 226-230. [Abstract] [PDF]  

M Egfjord, H Daugaard, and K Olgaard

Clearance of prednisone in isolated perfused livers of normal and uremic rats. Effects of acute and chronic cyclosporin A administration
Drug Metab Dispos 1990 18: 231-237. [Abstract] [PDF]  

H Billig, E Ziv, H Bar-On, and M Bialer

The disposition of valpromide in rats and the isolated perfused rat liver
Drug Metab Dispos 1990 18: 238-244. [Abstract] [PDF]  

A Tsuji, H Sato, I Tamai, H Adachi, T Nishihara, M Ishiguro, N Ohnuma, and T Noguchi

Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy
Drug Metab Dispos 1990 18: 245-252. [Abstract] [PDF]  

RA Morrison, SM Singhvi, AE Peterson, DA Pocetti, and BH Migdalof

Relative contribution of the gut, liver, and lung to the first-pass hydrolysis (bioactivation) of orally administered 14C-fosinopril sodium in dogs. In vivo and in vitro studies
Drug Metab Dispos 1990 18: 253-257. [Abstract] [PDF]  

K Yokogawa, E Nakashima, and F Ichimura

Effect of fat tissue volume on the distribution kinetics of biperiden as a function of age in rats
Drug Metab Dispos 1990 18: 258-263. [Abstract] [PDF]  

K Fukushima, M Arai, T Suwa, and T Satoh

Enzymatic reduction of an epoxysuccinic acid derivative by rat cecal microflora
Drug Metab Dispos 1990 18: 264-266. [PDF]  

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