Reviews:

W Levin

The 1988 Bernard B. Brodie Award lecture. Functional diversity of hepatic cytochromes P-450
Drug Metab Dispos 1990 18: 824-830. [PDF]  

Articles:

F Cumin, C Schnell, P Richert, F Raschdorf, A Probst, K Schmid, JM Wood, and M de Gasparo

Pharmacokinetics and tissue distribution of the renin inhibitor N-(2- (R)-benzyl-3-tert-butyl-sulfonyl-propionyl)-His-ChacVal-n-butylami ne in marmosets
Drug Metab Dispos 1990 18: 831-835. [Abstract] [PDF]  

JH Lin, IW Chen, EH Ulm, JR Gehret, and DE Duggan

Dose-dependent pharmacokinetics of MK-417, a potent carbonic anhydrase inhibitor, in rabbits following single and multiple doses
Drug Metab Dispos 1990 18: 836-841. [Abstract] [PDF]  

SM el Dareer, KF Tillery, LM Rose, RF Struck, and DL Hill

Disposition and metabolism of carbovir in mice dosed intravenously or orally
Drug Metab Dispos 1990 18: 842-845. [Abstract] [PDF]  

JF Brien, S Jimmo, FJ Brennan, PW Armstrong, and H Abdollah

Disposition of amiodarone and its proximate metabolite, desethylamiodarone, in the dog for oral administration of single-dose and short-term drug regimens
Drug Metab Dispos 1990 18: 846-851. [Abstract] [PDF]  

TB Vree, EW Beneken Kolmer, YA Hekster, M Shimoda, M Ono, and T Miura

Pharmacokinetics, N1-glucuronidation, and N4-acetylation of sulfa-6- monomethoxine in humans
Drug Metab Dispos 1990 18: 852-858. [Abstract] [PDF]  

DC Swinney

Progesterone metabolism in hepatic microsomes. Effect of the cytochrome P-450 inhibitor, ketoconazole, and the NADPH 5 alpha-reductase inhibitor, 4-MA, upon the metabolic profile in human, monkey, dog, and rat
Drug Metab Dispos 1990 18: 859-865. [Abstract] [PDF]  

JJ Diliberto, P Srinivas, D Overstreet, G Usha, LT Burka, and LS Birnbaum

Metabolism of citral, an alpha,beta-unsaturated aldehyde, in male F344 rats
Drug Metab Dispos 1990 18: 866-875. [Abstract] [PDF]  

S Yoshihara and K Tatsumi

Metabolism of diphenyl sulfoxide in perfused guinea pig liver. Involvement of aldehyde oxidase as a sulfoxide reductase
Drug Metab Dispos 1990 18: 876-881. [Abstract] [PDF]  

TS Chen, JP Jr Richie, and CA Lang

Life span profiles of glutathione and acetaminophen detoxification
Drug Metab Dispos 1990 18: 882-887. [Abstract] [PDF]  

DD Stiff and MA Zemaitis

Metabolism of the anticonvulsant agent zonisamide in the rat
Drug Metab Dispos 1990 18: 888-894. [Abstract] [PDF]  

B Monsarrat, E Mariel, S Cros, M Gares, D Guenard, F Gueritte-Voegelein, and M Wright

Taxol metabolism. Isolation and identification of three major metabolites of taxol in rat bile
Drug Metab Dispos 1990 18: 895-901. [Abstract] [PDF]  

O Nagata, M Murata, H Kato, T Terasaki, H Sato, and A Tsuji

Physiological pharmacokinetics of a new muscle-relaxant, inaperisone, combined with its pharmacological effect on blood flow rate
Drug Metab Dispos 1990 18: 902-910. [Abstract] [PDF]  

M Koob and W Dekant

Metabolism of hexafluoropropene. Evidence for bioactivation by glutathione conjugate formation in the kidney
Drug Metab Dispos 1990 18: 911-916. [Abstract] [PDF]  

AA Elfarra and IY Hwang

In vivo metabolites of S-(2-benzothiazolyl)-L-cysteine as markers of in vivo cysteine conjugate beta-lyase and thiol glucuronosyl transferase activities
Drug Metab Dispos 1990 18: 917-922. [Abstract] [PDF]  

TK Gerding, BF Drenth, RA de Zeeuw, PG Tepper, and AS Horn

Metabolism and disposition of the dopamine agonist 2-(N-propyl-N-2- thienylethylamino)-5-hydroxytetralin in conscious monkeys after subsequent i.v. oral, and ocular administration
Drug Metab Dispos 1990 18: 923-928. [Abstract] [PDF]  

DE Chapman, TJ Moore, SR Michener, and G Powis

Metabolism and covalent binding of [14C]toluene by human and rat liver microsomal fractions and liver slices
Drug Metab Dispos 1990 18: 929-936. [Abstract] [PDF]  

B Nuernberg, I Szelenyi, HT Schneider, and K Brune

Diflunisal disposition. Role of gastric absorption in the development of mucosal damage and anti-inflammatory potency in rodents
Drug Metab Dispos 1990 18: 937-942. [Abstract] [PDF]  

S Narimatsu, K Watanabe, T Matsunaga, I Yamamoto, S Imaoka, Y Funae, and H Yoshimura

Cytochrome P-450 isozymes in metabolic activation of delta 9- tetrahydrocannabinol by rat liver microsomes
Drug Metab Dispos 1990 18: 943-948. [Abstract] [PDF]  

FA Wong, JR Lloyd, and DW Graden

The metabolism of etintidine in rat, dog, and human
Drug Metab Dispos 1990 18: 949-953. [Abstract] [PDF]  

WJ Wijnands, JF Trooster, PC Teunissen, HA Cats, and TB Vree

Ciprofloxacin does not impair the elimination of diazepam in humans
Drug Metab Dispos 1990 18: 954-957. [Abstract] [PDF]  

DE Nerland and WM Jr Pierce

Identification of N-acetyl-S-(2,5-dihydroxyphenyl)-L-cysteine as a urinary metabolite of benzene, phenol, and hydroquinone
Drug Metab Dispos 1990 18: 958-961. [Abstract] [PDF]  

WS Beck, K Dietzel, G Geisslinger, H Engler, H Vergin, and K Brune

Effects of sodium salicylate on elimination kinetics of indomethacin and bile production in dogs
Drug Metab Dispos 1990 18: 962-967. [Abstract] [PDF]  

PM Franz, SL Anliker, JT Callaghan, KA DeSante, PH Dhahir, RL Nelson, and A Rubin

Disposition in humans of racemic picenadol, an opioid analgesic
Drug Metab Dispos 1990 18: 968-973. [Abstract] [PDF]  

KR Korzekwa, WF Trager, K Nagata, A Parkinson, and JR Gillette

Isotope effect studies on the mechanism of the cytochrome P-450IIA1- catalyzed formation of delta 6-testosterone from testosterone
Drug Metab Dispos 1990 18: 974-979. [Abstract] [PDF]  

BK Wong, TF Woolf, T Chang, and LR Whitfield

Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog
Drug Metab Dispos 1990 18: 980-986. [Abstract] [PDF]  

R Mehvar

Pharmacokinetics of propafenone enantiomers in rats
Drug Metab Dispos 1990 18: 987-991. [Abstract] [PDF]  

MJ Olson, CA Reidy, JT Johnson, and TC Pederson

Oxidative defluorination of 1,1,1,2-tetrafluoroethane by rat liver microsomes
Drug Metab Dispos 1990 18: 992-998. [Abstract] [PDF]  

LA Hoogenboom, MC Berghmans, A Van Veldhuizen, and HA Kuiper

The use of pig hepatocytes to study the biotransformation of beta- nortestosterone by pigs. Identification of glucuronidated 15 alpha- hydroxy-norandrostenedione as an important in vitro and in vivo metabolite
Drug Metab Dispos 1990 18: 999-1004. [Abstract] [PDF]  

U Fuhr, T Wolff, S Harder, P Schymanski, and AH Staib

Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes
Drug Metab Dispos 1990 18: 1005-1010. [Abstract] [PDF]  

H Foth, J Hellkamp, EM Kunellis, and GF Kahl

Pulmonary elimination and metabolism of 5-fluoro-2'-deoxyuridine in isolated perfused rat lung and lung slices
Drug Metab Dispos 1990 18: 1011-1017. [Abstract] [PDF]  

DW Kelly, CL Holder, WA Korfmacher, and W Jr Slikker

Plasma elimination and urinary excretion of methapyrilene in the rat
Drug Metab Dispos 1990 18: 1018-1024. [Abstract] [PDF]  

KP Vyas, PH Kari, HG Ramjit, SM Pitzenberger, and M Hichens

Metabolism of antiparkinson agent dopazinol by rat liver microsomes
Drug Metab Dispos 1990 18: 1025-1030. [Abstract] [PDF]  

KJ Woodcroft, EW Szczepan, LC Knickle, and JR Bend

Three N-aralkylated derivatives of 1-aminobenzotriazole as potent and isozyme-selective, mechanism-based inhibitors of guinea pig pulmonary cytochrome P-450 in vitro
Drug Metab Dispos 1990 18: 1031-1037. [Abstract] [PDF]  

AE Mutlib, RE Talaat, JG Slatter, and FS Abbott

Formation and reversibility of S-linked conjugates of N-(1-methyl-3,3- diphenylpropyl)isocyanate, an in vivo metabolite of N-(1-methyl-3,3- diphenylpropyl)formamaide, in rats
Drug Metab Dispos 1990 18: 1038-1045. [Abstract] [PDF]  

BF Thomas and BR Martin

In vitro metabolism of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl) phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol, a synthetic bicyclic cannabinoid analog
Drug Metab Dispos 1990 18: 1046-1054. [Abstract] [PDF]  

PK Yeung, SJ Mosher, MA Quilliam, and TJ Montague

Species comparison of pharmacokinetics and metabolism of diltiazem in humans, dogs, rabbits, and rats
Drug Metab Dispos 1990 18: 1055-1059. [Abstract] [PDF]  

R Lapka, S Smolik, and V Rejholec

Pharmacokinetics of flobufen and its main active metabolite in the rat
Drug Metab Dispos 1990 18: 1060-1064. [Abstract] [PDF]  

NK Brown and DJ Harvey

In vitro metabolism of cannabichromene in seven common laboratory animals
Drug Metab Dispos 1990 18: 1065-1070. [Abstract] [PDF]  

SS Liu, R Sandri, and DD Tang-Liu

Systemic pharmacokinetics of acetylenic retinoids in rats
Drug Metab Dispos 1990 18: 1071-1077. [Abstract] [PDF]  

KR Brouwer, RL St Claire, J Lagarde, JE Patanella, JS Walsh, and GT Miwa

The pharmacokinetics of (-)-carbovir in rats. Evidence for nonlinear elimination
Drug Metab Dispos 1990 18: 1078-1083. [Abstract] [PDF]  

JS Walsh, JE Patanella, SE Unger, KR Brouwer, and GT Miwa

The metabolism and excretion of carbovir, a carbocyclic nucleoside, in the rat
Drug Metab Dispos 1990 18: 1084-1091. [Abstract] [PDF]  

JE Patanella, JS Walsh, SE Unger, GT Miwa, PS Parry, MJ Daniel, and GL Evans

Identification of a glucuronide conjugate of the carbocyclic nucleoside, carbovir, isolated from marmoset urine
Drug Metab Dispos 1990 18: 1092-1095. [PDF]  

YZ Shu, JW Hubbard, G McKay, and KK Midha

Identification of phenolic doxepin glucuronides from patient urine and rat bile
Drug Metab Dispos 1990 18: 1096-1099. [PDF]  

PV Macrae, M Kirrs, FS Pullen, and MH Tarbit

Characterization of a quaternary, N-glucuronide metabolite of the imidazole antifungal, tioconazole
Drug Metab Dispos 1990 18: 1100-1102. [PDF]  

FA Wong and SC Flor

The metabolism of ofloxacin in humans
Drug Metab Dispos 1990 18: 1103-1104. [PDF]  

N Oldfield

The metabolic fate of 13-cis-retinoic acid in mouse skin microsomal preparations
Drug Metab Dispos 1990 18: 1105-1107. [PDF]  

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