Reviews:

FP Guengerich

The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals
Drug Metab Dispos 1993 21: 1-6. [PDF]  

Articles:

G Audibert, CG Saunier, and P du Souich

In vivo and in vitro effect of cimetidine, inflammation, and hypoxia on propofol kinetics
Drug Metab Dispos 1993 21: 7-12. [Abstract] [PDF]  

P Dechelotte, A Sabouraud, P Sandouk, I Hackbarth, and M Schwenk

Uptake, 3-, and 6-glucuronidation of morphine in isolated cells from stomach, intestine, colon, and liver of the guinea pig
Drug Metab Dispos 1993 21: 13-17. [Abstract] [PDF]  

AW Harrell, SM Wheeler, M Pennick, SE Clarke, and RJ Chenery

Evidence that famciclovir (BRL 42810) and its associated metabolites do not inhibit the 6 beta-hydroxylation of testosterone in human liver microsomes
Drug Metab Dispos 1993 21: 18-23. [Abstract] [PDF]  

B Clement, KL Lustig, and DM Ziegler

Oxidation of desmethylpromethazine catalyzed by pig liver flavin- containing monooxygenase. Number and nature of metabolites
Drug Metab Dispos 1993 21: 24-29. [Abstract] [PDF]  

NP Vermeulen, GS Baldew, G Los, JG McVie, and JJ De Goeij

Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds
Drug Metab Dispos 1993 21: 30-36. [Abstract] [PDF]  

S Kanekal and JP Kehrer

Evidence for peroxidase-mediated metabolism of cyclophosphamide
Drug Metab Dispos 1993 21: 37-42. [Abstract] [PDF]  

HP Eugster, M Probst, FE Wurgler, and C Sengstag

Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae
Drug Metab Dispos 1993 21: 43-49. [Abstract] [PDF]  

T Ebner and B Burchell

Substrate specificities of two stably expressed human liver UDP- glucuronosyltransferases of the UGT1 gene family
Drug Metab Dispos 1993 21: 50-55. [Abstract] [PDF]  

EA Roberts, ZW Xie, S Yang, and J Lipa

Inducibility of enzyme activities associated with the cytochrome P-450 1A family, ethoxyresorufin O-deethylase, and methoxyresorufin O- demethylase in human hepatocyte lines derived from normal liver tissue
Drug Metab Dispos 1993 21: 56-61. [Abstract] [PDF]  

DK Patel, RP Lewis, ML Hinton, DH Schroeder, JP Shockcor, RL Johnson, and CW Sigel

Pharmacokinetics and disposition in the rat of a DNA intercalator 502U83
Drug Metab Dispos 1993 21: 62-70. [Abstract] [PDF]  

M Mohler, J Cook, D Lewis, J Moore, D Sinicropi, A Championsmith, B Ferraiolo, and J Mordenti

Altered pharmacokinetics of recombinant human deoxyribonuclease in rats due to the presence of a binding protein
Drug Metab Dispos 1993 21: 71-75. [Abstract] [PDF]  

T Walle, UK Walle, KR Thornburg, and KL Schey

Stereoselective sulfation of albuterol in humans. Biosynthesis of the sulfate conjugate by HEP G2 cells
Drug Metab Dispos 1993 21: 76-80. [Abstract] [PDF]  

T Wikberg, A Vuorela, P Ottoila, and J Taskinen

Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans
Drug Metab Dispos 1993 21: 81-92. [Abstract] [PDF]  

D Godeneche, P Labarre, MF Moreau, JC Madelmont, M Rapp, J Papon, and A Veyre

Main urinary metabolites of two cysteamine-containing 2-(chloroethyl) nitrosoureas in rats
Drug Metab Dispos 1993 21: 93-99. [Abstract] [PDF]  

M Pongchaidecha and PT Daley-Yates

Clearance and tissue uptake following 4-hour and 24-hour infusions of pamidronate in rats
Drug Metab Dispos 1993 21: 100-104. [Abstract] [PDF]  

LA Sylvia and JT Gerig

Fluorine NMR studies of the metabolism of flumecinol (3-trifluoromethyl- alpha-ethylbenzhydrol)
Drug Metab Dispos 1993 21: 105-113. [Abstract] [PDF]  

TS Tracy, DP Wirthwein, and SD Hall

Metabolic inversion of (R)-ibuprofen. Formation of ibuprofenyl-coenzyme A
Drug Metab Dispos 1993 21: 114-120. [Abstract] [PDF]  

X Cheng and JA Ruth

A simplified methodology for quantitation of butadiene metabolites. Application to the study of 1,3-butadiene metabolism by rat liver microsomes
Drug Metab Dispos 1993 21: 121-124. [Abstract] [PDF]  

AK Cho, M Hiramatsu, DA Schmitz, EM Landaw, AS Chang, S Ramamurthy, and DJ Jenden

A pharmacokinetic study of phenylcyclohexyldiethylamine. An analog of phencyclidine
Drug Metab Dispos 1993 21: 125-132. [Abstract] [PDF]  

WG Taylor, TW Hall, and DD Vedres

Metabolism of N,N-diethylbenzamide and N,N-diethyl-alpha,alpha'-13C- benzamide by rat liver microsomes
Drug Metab Dispos 1993 21: 133-140. [Abstract] [PDF]  

RF Quijano, N Ohnishi, K Umeda, F Komada, S Iwakawa, and K Okumura

Effect of atropine on gastrointestinal motility and the bioavailability of cyclosporine A in rats
Drug Metab Dispos 1993 21: 141-143. [Abstract] [PDF]  

HC Porchet, JY Le Cotonnec, S Canali, and G Zanolo

Pharmacokinetics of recombinant human follicle stimulating hormone after intravenous, intramuscular, and subcutaneous administration in monkeys, and comparison with intravenous administration of urinary follicle stimulating hormone
Drug Metab Dispos 1993 21: 144-150. [Abstract] [PDF]  

J Thomassin, R Battaglia, C Allievi, MG Castelli, and M Strolin Benedetti

In vivo glucuronidation in rat and humans of 5,6-dihydro-7-(1H-imidazol- 1-yl)-naphthalene-2-carboxylic acid, a selective inhibitor of thromboxane synthase
Drug Metab Dispos 1993 21: 151-155. [Abstract] [PDF]  

C Maskasame, SM Lankford, and SA Bai

Effects of propranolol on the disposition and negative dromotropic activity of diltiazem in the dog during multiple dosing
Drug Metab Dispos 1993 21: 156-161. [Abstract] [PDF]  

WJ Ehlhardt, WJ Wheeler, AP Breau, SH Chay, and GM Birch

Biotransformation of the antiviral agent 1,3,4-thiadiazol-2-ylcyanamide (LY217896) and characteristics of a mesoionic ribose metabolite
Drug Metab Dispos 1993 21: 162-170. [Abstract] [PDF]  

B Edwall, A Arvidsson, D Lake-Bakaar, K Lanbeck-Vallen, and W Yisak

Disposition of oral [14C]cefcanel daloxate hydrochloride in healthy male subjects
Drug Metab Dispos 1993 21: 171-177. [Abstract] [PDF]  

T Bienvenu, G Pons, E Rey, G Thiroux, and G Olive

Caffeine metabolism in liver slices during postnatal development in rats
Drug Metab Dispos 1993 21: 178-180. [Abstract] [PDF]  

RA Voice, M Manis, and WW Weber

Inhibition of human red blood cell N-acetyltransferase
Drug Metab Dispos 1993 21: 181-183. [Abstract] [PDF]  

A Adedoyin, PR Perry, and GR Wilkinson

Hepatic elimination in the rat of ditekiren (U-71038), a renin inhibitor pseudohexapeptide
Drug Metab Dispos 1993 21: 184-188. [Abstract] [PDF]  

JM Trang, JD Prejean, RH James, RD Irwin, TJ Goehl, and JG Page

Zidovudine bioavailability and linear pharmacokinetics in female B6C3F1 mice
Drug Metab Dispos 1993 21: 189-193. [Abstract] [PDF]  

S Tandon, M Das, and SK Khanna

Biometabolic elimination and organ retention profile of argemone alkaloid, sanguinarine, in rats and guinea pigs
Drug Metab Dispos 1993 21: 194-197. [PDF]  

KB Alton, TM Chan, and B Pramanik

Identification of two novel indolic metabolites of (R),(R)-labetalol in monkey urine
Drug Metab Dispos 1993 21: 198-199. [PDF]  

HD Colby, M Levitt, and IW Larson

Zonal differences in the thermal lability of adrenal microsomal monooxygenases
Drug Metab Dispos 1993 21: 200-202. [PDF]  

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