DMD Noab BioDiscoveries - Shaping Drug Discovery

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January 1994; 22 (1)   [Index by Author]       Other Issues:  
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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)
To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

M Ohtani, H Kotaki, K Uchino, Y Sawada, and T Iga
Pharmacokinetic analysis of enterohepatic circulation of buprenorphine and its active metabolite, norbuprenorphine, in rats
Drug Metab Dispos 1994 22: 2-7. [Abstract] [PDF]  

T Hasegawa, M Nadai, L Wang, Y Takayama, K Kato, T Nabeshima, and N Kato
Renal excretion of famotidine and role of adenosine in renal failure induced by bacterial lipopolysaccharide in rats
Drug Metab Dispos 1994 22: 8-13. [Abstract] [PDF]  

J Yuan, JK Dunnick, ER Barnes, and JW Findlay
Codeine toxicokinetics in rats during a two-year dosed feed study
Drug Metab Dispos 1994 22: 14-20. [Abstract] [PDF]  

N Ohshima, H Kotaki, Y Sawada, and T Iga
Tissue distribution and metabolism of amitriptyline after repeated administration in rats
Drug Metab Dispos 1994 22: 21-25. [Abstract] [PDF]  

EU Eisenhardt and MH Bickel
Kinetics of tissue distribution and elimination of retinoid drugs in the rat. I. Acitretin
Drug Metab Dispos 1994 22: 26-30. [Abstract] [PDF]  

EU Eisenhardt and MH Bickel
Kinetics of tissue distribution and elimination of retinoid drugs in the rat. II. Etretinate
Drug Metab Dispos 1994 22: 31-35. [Abstract] [PDF]  

MD Hussain, YK Tam, MR Gray, and RT Coutts
Mechanisms of time-dependent kinetics of diltiazem in the isolated perfused rat liver
Drug Metab Dispos 1994 22: 36-42. [Abstract] [PDF]  

LM Anderson, R Koseniauskas, ES Burak, DL Logsdon, JP Carter, CL Driver, CT Gombar, PN Magee, and GW Harrington
Suppression of in vivo clearance of N-nitrosodimethylamine in mice by cotreatment with ethanol
Drug Metab Dispos 1994 22: 43-49. [Abstract] [PDF]  

K Ito, Y Sawada, Y Sugiyama, H Suzuki, M Hanano, and T Iga
Linear relationship between GABAA receptor occupancy of muscimol and glucose metabolic response in the conscious mouse brain. Clinical implication based on comparison with benzodiazepine receptor agonist
Drug Metab Dispos 1994 22: 50-54. [Abstract] [PDF]  

P de Miranda and TC Burnette
Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys
Drug Metab Dispos 1994 22: 55-59. [Abstract] [PDF]  

TC Burnette and P de Miranda
Metabolic disposition of the acyclovir prodrug valaciclovir in the rat
Drug Metab Dispos 1994 22: 60-64. [Abstract] [PDF]  

S Diamond, D Rakestraw, J O'Neil, GN Lam, and DD Christ
Induction of cytochromes P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine
Drug Metab Dispos 1994 22: 65-73. [Abstract] [PDF]  

S Kanekal and JP Kehrer
Metabolism of cyclophosphamide by lipoxygenases
Drug Metab Dispos 1994 22: 74-78. [Abstract] [PDF]  

Y Ishii, H Mukoyama, and M Ohtawa
In vitro biotransformation of finasteride in rat hepatic microsomes. Isolation and characterization of metabolites
Drug Metab Dispos 1994 22: 79-84. [Abstract] [PDF]  

BY Perotti, N Okudaira, T Prueksaritanont, and LZ Benet
FK 506 metabolism in male and female rat liver microsomes
Drug Metab Dispos 1994 22: 85-89. [Abstract] [PDF]  

CB Davis, CS Crysler, VK Boppana, KL Fong, GL Joseph, JJ Urbanski, RA Macia, and GR Rhodes
Disposition of growth hormone-releasing peptide (SK&F 110679) in rat and dog following intravenous or subcutaneous administration
Drug Metab Dispos 1994 22: 90-98. [Abstract] [PDF]  

YS Kang, U Bickel, and WM Pardridge
Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor
Drug Metab Dispos 1994 22: 99-105. [Abstract] [PDF]  

WG Taylor, TJ Danielson, RW Spooner, and LR Golsteyn
Pharmacokinetic assessment of the dermal absorption of N,N-diethyl-m- toluamide (DEET) in cattle
Drug Metab Dispos 1994 22: 106-112. [Abstract] [PDF]  

LJ Haberer and GM Pollack
Disposition and protein binding of valproic acid in the developing rat
Drug Metab Dispos 1994 22: 113-119. [Abstract] [PDF]  

GM Pollack, AP Spencer, TL Horton, and KL Brouwer
Site-dependent intestinal hydrolysis of valproate and morphine glucuronide in the developing rat
Drug Metab Dispos 1994 22: 120-123. [Abstract] [PDF]  

AW Harrell, SM Wheeler, P East, SE Clarke, and RJ Chenery
Use of rat and human in vitro systems to assess the effectiveness and enzymology of deoxy-guanine analogues as prodrugs of an antiviral agent
Drug Metab Dispos 1994 22: 124-128. [Abstract] [PDF]  

W Meuldermans, J Hendrickx, G Mannens, K Lavrijsen, C Janssen, J Bracke, L Le Jeune, W Lauwers, and J Heykants
The metabolism and excretion of risperidone after oral administration in rats and dogs
Drug Metab Dispos 1994 22: 129-138. [Abstract] [PDF]  

H Cheng, MS Schwartz, S Vickers, JD Gilbert, RD Amin, B Depuy, L Liu, JD Rogers, SM Pond, and CA Duncan
Metabolic disposition of simvastatin in patients with T-tube drainage
Drug Metab Dispos 1994 22: 139-142. [Abstract] [PDF]  

N Patel, G Birner, W Dekant, and MW Anders
Glutathione-dependent biosynthesis and bioactivation of S-(1,2- dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of dichloroacetylene, in rat tissues and subcellular fractions
Drug Metab Dispos 1994 22: 143-147. [Abstract] [PDF]  

SP Boom, MM Moons, and FG Russel
Renal tubular transport of cimetidine in the isolated perfused kidney of the rat
Drug Metab Dispos 1994 22: 148-153. [Abstract] [PDF]  

JA Sandberg, C Eckhoff, H Nau, and W Jr Slikker
Pharmacokinetics of 13-cis-, all-trans-, 13-cis-4-oxo-, and all-trans-4- oxo retinoic acid after intravenous administration in the cynomolgus monkey
Drug Metab Dispos 1994 22: 154-160. [Abstract] [PDF]  

Y Irshaid, A Adedoyin, M Lotze, and RA Branch
Monoacetyldapsone inhibition of dapsone N-hydroxylation by human and rat liver microsomes
Drug Metab Dispos 1994 22: 161-164. [Abstract] [PDF]  

CP Granvil, T Wang, G Batist, and IW Wainer
Influence of phenobarbital induction on the enantioselective N- dechloroethylation of ifosfamide enantiomers in the rat
Drug Metab Dispos 1994 22: 165-167. [PDF]  

VE Adusumalli, JK Wichmann, N Kucharczyk, M Kamin, RD Sofia, J French, M Sperling, B Bourgeois, O Devinsky, and FE Dreifuss
Drug concentrations in human brain tissue samples from epileptic patients treated with felbamate
Drug Metab Dispos 1994 22: 168-170. [PDF]  

RF Mayol, CA Cole, KE Colson, and EH Kerns
Isolation and identification of the major urinary metabolite of m- chlorophenylpiperazine in the rat
Drug Metab Dispos 1994 22: 171-174. [PDF]  

SK Kirkman, TA Hultin, and J Scatina
Distribution and excretion of 125I-ardeparin, a low molecular weight heparin, in rats and beagle dogs
Drug Metab Dispos 1994 22: 175-176. [PDF]  

GN Kumar, JE Jr Oatis, KR Thornburg, FJ Heldrich, ES 3rd Hazard, and T Walle
6 alpha-Hydroxytaxol: isolation and identification of the major metabolite of taxol in human liver microsomes
Drug Metab Dispos 1994 22: 177-179. [PDF]  

SP Faux and RD Combes
Interaction of cimetidine with oxidized and prereduced microsomal cytochrome P-450
Drug Metab Dispos 1994 22: 180-182. [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


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