Articles:

SC Kuemmerle, T Shen, and PF Hollenberg

Inactivation of purified rat liver cytochrome P-450 2B1 and rabbit liver cytochrome P-450 2B4 by N-methylcarbazole
Drug Metab Dispos 1994 22: 343-351. [Abstract] [PDF]  

BJ Ring, CJ Parli, MC George, and SA Wrighton

In vitro metabolism of zatosetron. Interspecies comparison and role of CYP 3A
Drug Metab Dispos 1994 22: 352-357. [Abstract] [PDF]  

MT Marino, JO Peggins, LD Brown, MR Urquhart, and TG Brewer

Pharmacokinetics and kinetic-dynamic modeling of an 8-aminoquinoline candidate anticyanide and antimalarial drug (WR242511)
Drug Metab Dispos 1994 22: 358-366. [Abstract] [PDF]  

M Kishimoto, R Kawamori, T Kamada, and T Inaba

Carbonyl reductase activity for acetohexamide in human erythrocytes
Drug Metab Dispos 1994 22: 367-370. [Abstract] [PDF]  

RJ Ferguson, MA Doll, TD Rustan, K Gray, and DW Hein

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N- acetyltransferase (NAT2) alleles
Drug Metab Dispos 1994 22: 371-376. [Abstract] [PDF]  

T Hasegawa, K Hara, and S Hata

Binding of dorzolamide and its metabolite, N-deethylated dorzolamide, to human erythrocytes in vitro
Drug Metab Dispos 1994 22: 377-382. [Abstract] [PDF]  

DM Stresser, GS Bailey, and DE Williams

Indole-3-carbinol and beta-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat
Drug Metab Dispos 1994 22: 383-391. [Abstract] [PDF]  

DM Stresser, DE Williams, LI McLellan, TM Harris, and GS Bailey

Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo
Drug Metab Dispos 1994 22: 392-399. [Abstract] [PDF]  

JH Lin, IW Chen, and FA deLuna

Nonlinear kinetics of alendronate. Plasma protein binding and bone uptake
Drug Metab Dispos 1994 22: 400-405. [Abstract] [PDF]  

A Hutchaleelaha, J Sukbuntherng, HH Chow, and M Mayersohn

Disposition kinetics of d- and l-amphetamine following intravenous administration of racemic amphetamine to rats
Drug Metab Dispos 1994 22: 406-411. [Abstract] [PDF]  

S Zbaida, CF Brewer, and WG Levine

Hepatic microsomal azoreductase activity. Reactivity of azo dye substrates is determined by their electron densities and redox potentials
Drug Metab Dispos 1994 22: 412-418. [Abstract] [PDF]  

PJ Bednarski, NA Kratochwil, and AM Otto

Reversible and irreversible interactions of a cisplatin analog bearing a 1,2-diphenylethylenediamine ligand with plasma and plasma proteins in vitro
Drug Metab Dispos 1994 22: 419-427. [Abstract] [PDF]  

RA Newman, A Fuentes, JM Covey, and JA Benvenuto

Preclinical pharmacology of the natural marine product dolastatin 10 (NSC 376128)
Drug Metab Dispos 1994 22: 428-432. [Abstract] [PDF]  

MS Nielsen, CE Olsen, J Dich, SB Christensen, and N Grunnet

Metabolism of thapsigargin in rat hepatocytes
Drug Metab Dispos 1994 22: 433-437. [Abstract] [PDF]  

DO Scott, DS Bindra, SC Sutton, and VJ Stella

Urinary and biliary disposition of the lactone and carboxylate forms of 20(S)-camptothecin in rats
Drug Metab Dispos 1994 22: 438-442. [Abstract] [PDF]  

H Heyn, DJ McCarthy, SH Curry, MS Eisman, and MW Anders

Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant
Drug Metab Dispos 1994 22: 443-446. [Abstract] [PDF]  

L Granero, MJ Gimeno, F Torres-Molina, J Chesa-Jimenez, and JE Peris

Studies on the renal excretion mechanisms of cefadroxil
Drug Metab Dispos 1994 22: 447-450. [Abstract] [PDF]  

CC Achkar, JM Bentel, JF Boylan, HI Scher, LJ Gudas, and WH Jr Miller

Differences in the pharmacokinetic properties of orally administered all-trans-retinoic acid and 9-cis-retinoic acid in the plasma of nude mice
Drug Metab Dispos 1994 22: 451-458. [Abstract] [PDF]  

GL Qiao, PL Williams, and JE Riviere

Percutaneous absorption, biotransformation, and systemic disposition of parathion in vivo in swine. I. Comprehensive pharmacokinetic model
Drug Metab Dispos 1994 22: 459-471. [Abstract] [PDF]  

JA Vitarius and LG Sultatos

Kinetic mechanism of the detoxification of the organophosphate paraoxon by human serum A-esterase
Drug Metab Dispos 1994 22: 472-478. [Abstract] [PDF]  

T Fukuyama, K Yamaoka, Y Ohata, and T Nakagawa

A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats
Drug Metab Dispos 1994 22: 479-485. [Abstract] [PDF]  

B Clement and F Jung

N-hydroxylation of the antiprotozoal drug pentamidine catalyzed by rabbit liver cytochrome P-450 2C3 or human liver microsomes, microsomal retroreduction, and further oxidative transformation of the formed amidoximes. Possible relationship to the biological oxidation of arginine to NG-hydroxyarginine, citrulline, and nitric oxide
Drug Metab Dispos 1994 22: 486-497. [Abstract] [PDF]  

BS Levine and IR Tebbett

Cocaine pharmacokinetics in ethanol-pretreated rats
Drug Metab Dispos 1994 22: 498-500. [PDF]  

Letters:

AM Monro

Are routine tissue distribution studies justifiable for approval of human drugs? [letter] [see comments]
Drug Metab Dispos 1994 22: 341-342. [PDF]  

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