DMD Noab BioDiscoveries - Shaping Drug Discovery

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July 1995; 23 (7)   [Index by Author]       Other Issues:  
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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)
To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

A Cribb, C Nuss, and R Wang
Antipeptide antibodies against overlapping sequences differentially inhibit human CYP2D6
Drug Metab Dispos 1995 23: 671-675. [Abstract] [PDF]  

LR Phillips, L Malspeis, and JG Supko
Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog
Drug Metab Dispos 1995 23: 676-680. [Abstract] [PDF]  

RC Zangar, KJ Woodcroft, TA Kocarek, and RF Novak
Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes
Drug Metab Dispos 1995 23: 681-687. [Abstract] [PDF]  

T Prueksaritanont, SK Balani, LM Dwyer, JD Ellis, LR Kauffman, SL Varga, SM Pitzenberger, and AD Theoharides
Species differences in the metabolism of a potent HIV-1 reverse transcriptase inhibitor L-738,372. In vivo and in vitro studies in rats, dogs, monkeys, and human
Drug Metab Dispos 1995 23: 688-695. [Abstract] [PDF]  

JT Buters, M Shou, JP Hardwick, KR Korzekwa, and FJ Gonzalez
cDNA-directed expression of human cytochrome P450 CYP1A1 using baculovirus. Purification, dependency on NADPH-P450 oxidoreductase, and reconstitution of catalytic properties without purification
Drug Metab Dispos 1995 23: 696-701. [Abstract] [PDF]  

SL Born, GH John, GR Harlow, and JR Halpert
Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis
Drug Metab Dispos 1995 23: 702-707. [Abstract] [PDF]  

AA Acheampong, M Shackleton, and DD Tang-Liu
Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits
Drug Metab Dispos 1995 23: 708-712. [Abstract] [PDF]  

F Innocenti, R Danesi, A Di Paolo, C Agen, D Nardini, G Bocci, and M Del Tacca
Plasma and tissue disposition of paclitaxel (taxol) after intraperitoneal administration in mice
Drug Metab Dispos 1995 23: 713-717. [Abstract] [PDF]  

M Katashima, K Yamamoto, M Sugiura, Y Sawada, and T Iga
Comparative pharmacokinetic/pharmacodynamic study of proton pump inhibitors, omeprazole and lansoprazole in rats
Drug Metab Dispos 1995 23: 718-723. [Abstract] [PDF]  

RJ Cannell, AR Knaggs, MJ Dawson, GR Manchee, PJ Eddershaw, I Waterhouse, DR Sutherland, GD Bowers, and PJ Sidebottom
Microbial biotransformation of the angiotensin II antagonist GR117289 by Streptomyces rimosus to identify a mammalian metabolite
Drug Metab Dispos 1995 23: 724-729. [Abstract] [PDF]  

JH Lin, IW Chen, KJ Vastag, and D Ostovic
pH-dependent oral absorption of L-735,524, a potent HIV protease inhibitor, in rats and dogs
Drug Metab Dispos 1995 23: 730-735. [Abstract] [PDF]  

P Bullock, R Pearce, A Draper, J Podval, W Bracken, J Veltman, P Thomas, and A Parkinson
Induction of liver microsomal cytochrome P450 in cynomolgus monkeys
Drug Metab Dispos 1995 23: 736-748. [Abstract] [PDF]  

TJ Carlson, JP Jones, L Peterson, N Jr Castagnoli, KR Iyer, and WF Trager
Stereoselectivity and isotope effects associated with cytochrome P450- catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5- nicotinium ion
Drug Metab Dispos 1995 23: 749-756. [Abstract] [PDF]  

BS Kuo, BS Mathews, JD Stuhler, BK Carrel, J Ho, and JQ Rose
Disposition and cardioselectivity of MDL 74,405, a vitamin E-like free radical scavenger, in rats and dogs after intravenous infusion
Drug Metab Dispos 1995 23: 757-764. [Abstract] [PDF]  

AD Rodrigues, DJ Mulford, RD Lee, BW Surber, MJ Kukulka, JL Ferrero, SB Thomas, MS Shet, and RW Estabrook
In vitro metabolism of terfenadine by a purified recombinant fusion protein containing cytochrome P4503A4 and NADPH-P450 reductase. Comparison to human liver microsomes and precision-cut liver tissue slices
Drug Metab Dispos 1995 23: 765-775. [Abstract] [PDF]  

CA Elder and MW Modi
Interspecies scaling of a thienodiazepine platelet-activating factor receptor antagonist
Drug Metab Dispos 1995 23: 776-778. [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


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