Noab BioDiscoveries - Shaping Drug Discovery

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January 1997; 25 (1)   [Index by Author]       Other Issues:  
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Articles:

Joanna M. Little, Paul A. Lehman, Susan Nowell, Victor Samokyszyn, and Anna Radominska
Glucuronidation of all-trans-Retinoic Acid and 5,6-Epoxy-all-trans-retinoic Acid. Activation of Rat Liver Microsomal UDP-Glucuronosyltransferase Activity by Alamethicin
Drug Metab Dispos 1997 25: 5-11. [Abstract] [Full Text] [PDF]  

Monicah A. Otieno, Raymond B. Baggs, John D. Hayes, and M. W. Anders
Immunolocalization of Microsomal Glutathione S-TraNsferase in Rat Tissues
Drug Metab Dispos 1997 25: 12-20. [Abstract] [Full Text] [PDF]  

Qing-Yu Zhang, Janet Wikoff, Deborah Dunbar, Michael Fasco, and Laurence Kaminsky
Regulation of Cytochrome P4501A1 Expression in Rat Small Intestine
Drug Metab Dispos 1997 25: 21-26. [Abstract] [Full Text] [PDF]  

Tzu-Wen Shih, Tsu-Han Lin, Y. Fulmer Shealy, and Donald L. Hill
Nonenzymatic Isomerization of 9-CIS-Retinoic Acid Catalyzed by Sulfhydryl Compounds
Drug Metab Dispos 1997 25: 27-32. [Abstract] [Full Text] [PDF]  

J. C. Maurizis, J. C. Madelmont, M. Rapp, C. Marijnen, M. C. Cerf, J. M. Gillardin, F. Lepage, and A. Veyre
Disposition and Metabolism of 2,6-Dimethylbenzamide N-(5-Methyl-3-isoxazolyl) (D2916) in Male and Female Rats
Drug Metab Dispos 1997 25: 33-39. [Abstract] [Full Text] [PDF]  

Steven W. Martin, Frances E. Bishop, Brad M. Kerr, Markus Moor, Martha Moore, Pamela Sheffels, Mohammed Rashed, J. Greg Slatter, Laurence Berthon-Cédille, Francis Lepage, Jean-Jacques Descombe, Michel Picard, Thomas A. Baillie, and René H. Levy
Pharmacokinetics and Metabolism of the Novel Anticonvulsant Agent N-(2,6-Dimethylphenyl)-5-methyl-3-isoxazolecarboxamide (D2624) in Rats and Humans
Drug Metab Dispos 1997 25: 40-46. [Abstract] [Full Text] [PDF]  

Peter A. Crooks, Min Li, and Linda P. Dwoskin
Metabolites of Nicotine in Rat Brain After Peripheral Nicotine Administration. Cotinine, Nornicotine, and Norcotinine
Drug Metab Dispos 1997 25: 47-54. [Abstract] [Full Text] [PDF]  

Benedetta C. Sallustio, Barbara A. Fairchild, and Peter R. Pannall
Interaction of Human Serum Albumin with the Electrophilic Metabolite 1-O-Gemfibrozil-beta -D-Glucuronide
Drug Metab Dispos 1997 25: 55-60. [Abstract] [Full Text] [PDF]  

C. Y. Ng, H. Ghabrial, D. J. Morgan, R. A. Smallwood, and P. W. Angus
Effects of Acute Myocardial Infarction on Theophylline Elimination in Rats
Drug Metab Dispos 1997 25: 61-65. [Abstract] [Full Text] [PDF]  

Eun J. Yoon, Hyun J. Shim, Jong J. Lee, Sang D. Lee, Won B. Kim, Junnick Yang, and Myung G. Lee
Pharmacokinetics of DA-125, A New Anthracycline, After Intravenous Administration to Spontaneously Hypertensive Rats and DOCA-Salt-Induced Hypertensive Rats
Drug Metab Dispos 1997 25: 66-74. [Abstract] [Full Text] [PDF]  

Yoshitaka Yamaguchi, Shirou Kirita, Takahiko Baba, Junko Aoyama, Akira Touchi, Robert H. Tukey, F. Peter Guengerich, and Takashi Matsubara
IDENTIFICATION OF RAT AND HUMAN CYTOCHROME P450 FORMS INVOLVED IN THE METABOLISM OF THE THROMBOXANE A2 RECEPTOR ANTAGONIST (+)-S-145
Drug Metab Dispos 1997 25: 75-80. [Abstract] [Full Text] [PDF]  

Kelem Kassahun, Edward Mattiuz, Eldon Nyhart, Jr., Boyd Obermeyer, Todd Gillespie, Anthony Murphy, R. Michael Goodwin, David Tupper, J. Thomas Callaghan, and Louis Lemberger
Disposition and Biotransformation of the Antipsychotic Agent Olanzapine in Humans
Drug Metab Dispos 1997 25: 81-93. [Abstract] [Full Text] [PDF]  

Laurent Placidi, Erika Cretton Scott, Georges de Sousa, Roger Rahmani, Michel Placidi, and Jean-Pierre Sommadossi
Interspecies Variability of TNP-470 Metabolism, Using Primary Monkey, Rat, and Dog Cultured Hepatocytes
Drug Metab Dispos 1997 25: 94-99. [Abstract] [Full Text] [PDF]  

J. R. Carlin, P. Christofalo, B. H. Arison, R. E. Ellsworth, A. Rosegay, R. R. Miller, S. H. L. Chiu, and W. J. A. Vandenheuvel
Disposition and Metabolism of Finasteride in Dogs
Drug Metab Dispos 1997 25: 100-109. [Abstract] [Full Text] [PDF]  

Gondi N. Kumar, Erik Dubberke, A. David Rodrigues, Ellen Roberts, and Jon F. Dennisen
Identification of Cytochromes P450 Involved in the Human Liver Microsomal Metabolism of the Thromboxane A2 Inhibitor Seratrodast (ABT-001)
Drug Metab Dispos 1997 25: 110-115. [Abstract] [Full Text] [PDF]  

Tomoyuki Ohe, Tadahiko Mashino, and Masaaki Hirobe
Substituent Elimination From p-Substituted Phenols by Cytochrome P450. ipso-Substitution by the Oxygen Atom of the Active Species
Drug Metab Dispos 1997 25: 116-122. [Abstract] [Full Text] [PDF]  

Michael W. Sinz, Ann E. Black, Susan M. Bjorge, Ann Holmes, Bharat K. Trivedi, and Thomas F. Woolf
In Vitro and In Vivo Disposition of 2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a Novel Five-Carbon Cleavage Metabolite in Rats
Drug Metab Dispos 1997 25: 123-130. [Abstract] [Full Text] [PDF]  

Errata:

Correction for vol. 24, p. 1020
Drug Metab Dispos 1997 25: 131. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


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