DMD -- Table of Contents (27 [1])

Noab BioDiscoveries - Shaping Drug Discovery

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January 1999; 27 (1)   [Index by Author] [Cover Caption]

       Reviews

       Articles

       Short Communications

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Reviews:

Sanjeev Kaul, Kishor A. Dandekar, Beth E. Schilling, and Rashmi H. Barbhaiya: Toxicokinetics of 2',3'-Didehydro-3'-Deoxythymidine, Stavudine (D4T)
Drug Metab Dispos 1999 27: 1-12. [Abstract] [Full Text] [PDF]

Articles:

C. Clifford Conaway, Ding Jiao, Toshiyuki Kohri, Leonard Liebes, and Fung-Lung Chung: Disposition and Pharmacokinetics of Phenethyl Isothiocyanate and 6-Phenylhexyl Isothiocyanate in F344 Rats
Drug Metab Dispos 1999 27: 13-20. [Abstract] [Full Text] [PDF]

Wolfgang F. Richter, Harald Gallati, and Claus-Dieter Schiller: Animal Pharmacokinetics of the Tumor Necrosis Factor Receptor-Immunoglobulin Fusion Protein Lenercept and Their Extrapolation to Humans
Drug Metab Dispos 1999 27: 21-25. [Abstract] [Full Text] [PDF]

Christine J. Meunier and Roger K. Verbeeck: Glucuronidation of R- and S-Ketoprofen, Acetaminophen, and Diflunisal by Liver Microsomes of Adjuvant-Induced Arthritic Rats
Drug Metab Dispos 1999 27: 26-31. [Abstract] [Full Text] [PDF]

C. L. Fernández-Metzler, K. G. Owens*, T. A. Baillie, and R. C. King: Rapid Liquid Chromatography with Tandem Mass Spectrometry-Based Screening Procedures for Studies on the Biotransformation of Drug Candidates
Drug Metab Dispos 1999 27: 32-40. [Abstract] [Full Text] [PDF]

Suresh K. Balani, Laura R. Kauffman, Florencia A. deLuna, and Jiunn H. Lin: Nonlinear Pharmacokinetics of Efavirenz (DMP-266), a Potent HIV-1 Reverse Transcriptase Inhibitor, in Rats and Monkeys
Drug Metab Dispos 1999 27: 41-45. [Abstract] [Full Text] [PDF]

Sharon L. Ripp, Kiyoshi Itagaki, Richard M. Philpot, and Adnan A. Elfarra: Species and Sex Differences in Expression of Flavin-Containing Monooxygenase Form 3 in Liver and Kidney Microsomes
Drug Metab Dispos 1999 27: 46-52. [Abstract] [Full Text] [PDF]

Miguel A. Sogorb, Inés Sánchez, Manuel López-Rivadulla, Virtudes Céspedes, and Eugenio Vilanova: EDTA-Resistant and Sensitive Phosphotriesterase Activities Associated with Albumin and Lipoproteins in Rabbit Serum
Drug Metab Dispos 1999 27: 53-59. [Abstract] [Full Text] [PDF]

Katsumi Sugiyama, Tao-Chin Lin Wang, John T. Simpson, Libaniel Rodriguez, Peter F. Kador, and Sanai Sato: Aldose Reductase Catalyzes the Oxidation of Naphthalene-1,2-Dihydrodiol for the Formation of Ortho-Naphthoquinone
Drug Metab Dispos 1999 27: 60-67. [Abstract] [Full Text] [PDF]

Poh-Gek Forkert, Alvin M. Malkinson, Pamela Rice, and Madeleine Moussa: Diminished CYP2E1 Expression and Formation of 2-S-Glutathionyl Acetate, a Glutathione Conjugate Derived from 1,1-Dichloroethylene Epoxide, in Murine Lung Tumors
Drug Metab Dispos 1999 27: 68-73. [Abstract] [Full Text] [PDF]

K. Madhava Madyastha and Nilesh W. Gaikwad: Metabolic Disposition of a Monoterpene Ketone, Piperitenone, in Rats: Evidence for the Formation of a Known Toxin, p-cresol
Drug Metab Dispos 1999 27: 74-80. [Abstract] [Full Text] [PDF]

Vincent Pichette, David Geadah, and Patrick du Souich: Role of Plasma Protein Binding on Renal Metabolism and Dynamics of Furosemide in the Rabbit
Drug Metab Dispos 1999 27: 81-85. [Abstract] [Full Text] [PDF]

Gondi N. Kumar, Venkata Jayanti, Ronald D. Lee, David N. Whittern, John Uchic, Samuel Thomas, Paulette Johnson, Brian Grabowski, Hing Sham, David Betebenner, Dale J. Kempf, and Jon F. Denissen: In Vitro Metabolism of the HIV-1 Protease Inhibitor ABT-378: Species Comparison and Metabolite Identification
Drug Metab Dispos 1999 27: 86-91. [Abstract] [Full Text] [PDF]

Shigeyuki Kitamura, Kazumi Sugihara, and Kiyoshi Tatsumi: A Unique Tertiary Amine N-Oxide Reduction System Composed of Quinone Reductase and Heme in Rat Liver Preparations
Drug Metab Dispos 1999 27: 92-97. [Abstract] [Full Text] [PDF]

Jin-ding Huang, Wei-Chung Guo, Ming-Derg Lai, Yueleong Leon Guo, and George H. Lambert: Detection of a Novel Cytochrome P-450 1A2 polymorphism (F21L) in Chinese
Drug Metab Dispos 1999 27: 98-101. [Abstract] [Full Text] [PDF]

Tian J. Yang, Kristopher W. Krausz, Yang Sai, Frank J. Gonzalez, and Harry V. Gelboin: Eight Inhibitory Monoclonal Antibodies Define the Role of Individual P-450s in Human Liver Microsomal Diazepam, 7-Ethoxycoumarin, and Imipramine Metabolism
Drug Metab Dispos 1999 27: 102-109. [Abstract] [Full Text] [PDF]

B. W. Corrigan, B. Nicholls, B. Thakrar, R. Lam, C. Grosse, J. Alianti, and J. L. Palmer: Heterogeneity in Systemic Availability of Ondansetron and Granisetron following Oral Administration
Drug Metab Dispos 1999 27: 110-112. [Abstract] [Full Text] [PDF]

Yandong Wen, Rory P. Remmel, and Cheryl L. Zimmerman: First-Pass Disposition of ( $-$ )-6-Aminocarbovir in Rats. I. Prodrug Activation May Be Limited by Access to Enzyme
Drug Metab Dispos 1999 27: 113-121. [Abstract] [Full Text] [PDF]

Marcelo G. Luquita, Viviana A. Catania, Enrique J. Sánchez-Pozzi, Mary Vore, and Aldo D. Mottino: Prolactin Increases the Hepatic Content of µ-Class Subunits of Glutathione S-Transferase in the Rat
Drug Metab Dispos 1999 27: 122-124. [Abstract] [Full Text] [PDF]

Klaus Gjervig Jensen and Lars Dalgaard: In Vitro Metabolism of the M1-Muscarinic Agonist 5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by Human Hepatic Cytochromes P-450 Determined at pH 7.4 and 8.5
Drug Metab Dispos 1999 27: 125-132. [Abstract] [Full Text] [PDF]

Song Ren, Thomas F. Kalhorn, and John T. Slattery: Inhibition of Human Aldehyde Dehydrogenase 1 by the 4-Hydroxycyclophosphamide Degradation Product Acrolein
Drug Metab Dispos 1999 27: 133-137. [Abstract] [Full Text] [PDF]

Kelly J. Dix, Donna P. Coleman, and A. Robert Jeffcoat: Comparative Metabolism and Disposition of Gemfibrozil in Male and Female Sprague-Dawley Rats and Syrian golden Hamsters
Drug Metab Dispos 1999 27: 138-146. [Abstract] [Full Text] [PDF]

Brian F. Thomas, Jason P. Burgess, Donna P. Coleman, Nicole M. Scheffler, A. Robert Jeffcoat, and Kelly J. Dix: Isolation and identification of novel metabolites of gemfibrozil in rat urine
Drug Metab Dispos 1999 27: 147-157. [Abstract] [Full Text] [PDF]

Short Communications:

Tadao Konishi, Hitoshi Nishikawa, Shigeyuki Kitamura, and Kiyoshi Tatsumi: In Vivo Studies on Chiral Inversion and Amino Acid Conjugation of 2-[4-(3-Methyl-2-thienyl)phenyl]propionic Acid in Rats and Dogs
Drug Metab Dispos 1999 27: 158-160. [Abstract] [Full Text] [PDF]

Cover Caption:

Detection of a novel CYP1A2 polymorphism. (Left) Analysis of PCR-extended fragments from exon 2 of CYP1A2. Lanes 1 and 2 [without (\-) and with (+) MboII digestion] are from a sample of homozygous C₂₈₆₆. Lanes 3 and 4 [without (\-) and with (+) MboII digestion)] are from a sample of heterozygous C/G₂₈₆₆. (Right) Sequencing gel of the PCR product containing heterozygous C/G₂₈₆₆ in exon 2. See the article in this issue by Huang et al. on page 98 for further details.