Articles:

Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada, and Tatsuji Iga

Correlation between In Vivo and In Vitro Hepatic Uptake of Metabolic Inhibitors of Cytochrome P-450 in Rats
Drug Metab Dispos 1999 27: 1225-1231. [Abstract] [Full Text] [PDF]  

Keith W. Ward, Leonard M. Azzarano, William E. Bondinell, Russell D. Cousins, William F. Huffman, Dalia R. Jakas, Richard M. Keenan, Thomas W. Ku, Dave Lundberg, William H. Miller, Jayme A. Mumaw, Kenneth A. Newlander, Jill L. Pirhalla, Theresa J. Roethke, Kevin L. Salyers, Pamela R. Souder, Gary J. Stelman, and Brian R. Smith

Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist
Drug Metab Dispos 1999 27: 1232-1241. [Abstract] [Full Text] [PDF]  

Hideyuki Yamada, Yumie Matsuki, Tohru Yamaguchi, and Kazuta Oguri

Effect of a Ligand Selective for Peripheral Benzodiazepine Receptors on the Expression of Rat Hepatic P-450 Cytochromes: Assessment of the Effect In Vivo and in a Hepatocyte Culture System
Drug Metab Dispos 1999 27: 1242-1247. [Abstract] [Full Text] [PDF]  

Kazuki Akira, Eiji Negishi, Chiseko Sakuma, and Takao Hashimoto

Direct Detection of Antipyrine Metabolites in Rat Urine by ¹³C Labeling and NMR Spectroscopy
Drug Metab Dispos 1999 27: 1248-1253. [Abstract] [Full Text] [PDF]  

Akio Suzuki, Izumi Iida, Fumie Tanaka, Masayuki Akimoto, Kiyomi Fukushima, Masayoshi Tani, Takashi Ishizaki, and Kan Chiba

Identification of Human Cytochrome P-450 Isoforms Involved in Metabolism of R(+)- and S()-Gallopamil: Utility of In Vitro Disappearance Rate
Drug Metab Dispos 1999 27: 1254-1259. [Abstract] [Full Text] [PDF]  

Hiroshi Yamazaki, Ayaka Shibata, Mikie Suzuki, Miki Nakajima, Noriaki Shimada, F. Peter Guengerich, and Tsuyoshi Yokoi

Oxidation of Troglitazone to a Quinone-Type Metabolite Catalyzed by Cytochrome P-450 2C8 and P-450 3A4 in Human Liver Microsomes
Drug Metab Dispos 1999 27: 1260-1266. [Abstract] [Full Text] [PDF]  

Sudarsanan Varaprath, Kevin L. Salyers, Kathleen P. Plotzke, and Shrenik Nanavati

Identification of Metabolites of Octamethylcyclotetrasiloxane (D₄) in Rat Urine
Drug Metab Dispos 1999 27: 1267-1273. [Abstract] [Full Text] [PDF]  

Tsutomu Shimada, Fujiko Tsumura, and Hiroshi Yamazaki

Prediction of Human Liver Microsomal Oxidations of 7-Ethoxycoumarin and Chlorzoxazone with Kinetic Parameters of Recombinant Cytochrome P-450 Enzymes
Drug Metab Dispos 1999 27: 1274-1280. [Abstract] [Full Text] [PDF]  

Udo Mey, Helmut Wachsmuth, and Ursula Breyer-Pfaff

Conjugation of the Enantiomers of Ketotifen to Four Isomeric Quaternary Ammonium Glucuronides in Humans In Vivo and in Liver Microsomes
Drug Metab Dispos 1999 27: 1281-1292. [Abstract] [Full Text] [PDF]  

Michael H. Court, Bonnie L. Hay-Kraus, Dennis W. Hill, Albert J. Kind, and David J. Greenblatt

Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences
Drug Metab Dispos 1999 27: 1293-1299. [Abstract] [Full Text] [PDF]  

Hans Gelderblom, Jaap Verweij, Eric Brouwer, Marrimuthoo Pillay, Peter de Bruijn, Kees Nooter, Gerrit Stoter, and Alex Sparreboom

Disposition of [G-³H]paclitaxel and Cremophor EL in a Patient with Severely Impaired Renal Function
Drug Metab Dispos 1999 27: 1300-1305. [Abstract] [Full Text] [PDF]  

Hao Chen, Monica R. Brzezinski, Alan G. Fantel, and Mont R. Juchau

Catalysis of Drug Oxidation during Embryogenesis in Human Hepatic Tissues using Imipramine as a Model Substrate
Drug Metab Dispos 1999 27: 1306-1308. [Abstract] [Full Text] [PDF]  

Partha Roy, Olga Tretyakov, Joel Wright, and David J. Waxman

Stereoselective Metabolism of Ifosfamide by Human P-450s 3A4 and 2B6. Favorable Metabolic Properties of R-Enantiomer
Drug Metab Dispos 1999 27: 1309-1318. [Abstract] [Full Text] [PDF]  

A. E. Mutlib, H. Chen, G. A. Nemeth, J. A. Markwalder, S. P. Seitz, L. S. Gan, and D. D. Christ

Identification and Characterization of Efavirenz Metabolites by Liquid Chromatography/Mass Spectrometry and High Field NMR: Species Differences in the Metabolism of Efavirenz
Drug Metab Dispos 1999 27: 1319-1333. [Abstract] [Full Text] [PDF]  

Larry C. Wienkers, Cecilia Allievi, Michael J. Hauer, and Michael A. Wynalda

Cytochrome P-450-Mediated Metabolism of the Individual Enantiomers of the Antidepressant Agent Reboxetine in Human Liver Microsomes
Drug Metab Dispos 1999 27: 1334-1340. [Abstract] [Full Text] [PDF]  

Ellen Bech Christensen, Jan Bruun Andersen, Henrik Pedersen, Klaus Gjervig Jensen, and Lars Dalgaard

Metabolites of [¹⁴C]-5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine in Mice, Rats, Dogs, and Humans
Drug Metab Dispos 1999 27: 1341-1349. [Abstract] [Full Text] [PDF]  

R. Scott Obach

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
Drug Metab Dispos 1999 27: 1350-1359. [Abstract] [Full Text] [PDF]  

Stanley Vickers, Anthony D. Theoharides, Byron Arison, Suresh K. Balani, Dan Cui, Carol A. Duncan, Joan D. Ellis, Lynn M. Gorham, Stacey L. Polsky, Thomayant Prueksaritanont, Harri G. Ramjit, Donald E. Slaughter, and Kamlesh P. Vyas

In Vitro and In Vivo Studies on the Metabolism of Tirofiban
Drug Metab Dispos 1999 27: 1360-1366. [Abstract] [Full Text] [PDF]  

Su-Er W. Huskey, Debra Luffer-Atlas, Brian J. Dean, Erin M. McGowan, William P. Feeney, and Shuet-Hing Lee Chiu

Substance P Receptor Antagonist I: Conversion of Phosphoramidate Prodrug after i.v. Administration to Rats and Dogs
Drug Metab Dispos 1999 27: 1367-1373. [Abstract] [Full Text] [PDF]  

Errata:

Correction for vol. 27, p. 1187
Drug Metab Dispos 1999 27: 1374. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.