DMD -- Table of Contents (27 [2])

Noab BioDiscoveries - Shaping Drug Discovery

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February 1999; 27 (2)   [Index by Author] [Cover Caption]

       Symposium Articles

       Articles

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Symposium Articles:

Stephen D. Hall, Kenneth E. Thummel, Paul B. Watkins, Kenneth S. Lown, Leslie Z. Benet, Mary F. Paine, Robert R. Mayo, D. Kim Turgeon, David G. Bailey, Robert J. Fontana, and Steven A. Wrighton: Molecular and Physical Mechanisms of First-Pass Extraction
Drug Metab Dispos 1999 27: 161-166. [Abstract] [Full Text] [PDF]

Articles:

Regina W. Wang, Deborah J. Newton, Nini Y. Liu, Magang Shou, Tom Rushmore, and Anthony Y. H. Lu: Inhibitory Anti-CYP3A4 Peptide Antibody: Mapping of Inhibitory Epitope and Specificity Toward Other CYP3A Isoforms
Drug Metab Dispos 1999 27: 167-172. [Abstract] [Full Text] [PDF]

Wolfgang Jacobsen, Gabriele Kirchner, Katrin Hallensleben, Laviero Mancinelli, Michael Deters, Ingelore Hackbarth, Leslie Z. Benet, Karl-Fr. Sewing, and Uwe Christians: Comparison of Cytochrome P-450-Dependent Metabolism and Drug Interactions of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Lovastatin and Pravastatin in the Liver
Drug Metab Dispos 1999 27: 173-179. [Abstract] [Full Text] [PDF]

Megan A. Gibbs, Kenneth E. Thummel, Danny D. Shen, and Kent L. Kunze: Inhibition of Cytochrome P-450 3A (CYP3A) in Human Intestinal and Liver Microsomes: Comparison of K_i Values and Impact of CYP3A5 Expression
Drug Metab Dispos 1999 27: 180-187. [Abstract] [Full Text] [PDF]

Toshio Chow, Susumu Imaoka, Toyoko Hiroi, and Yoshihiko Funae: Developmental Changes in the Catalytic Activity and Expression of CYP2D Isoforms in the Rat Liver
Drug Metab Dispos 1999 27: 188-192. [Abstract] [Full Text] [PDF]

David W. Singleton, Xiang-Dong Lei, Stephanie J. Webb, Russell A. Prough, and Thomas E. Geoghegan: Cytochrome P-450 mRNAs Are Modulated by Dehydroepiandrosterone, Nafenopin, and Triiodothyronine
Drug Metab Dispos 1999 27: 193-200. [Abstract] [Full Text] [PDF]

M. Kent Shellenberger, Lesley Groves, Jaymin Shah, and Gary D. Novack: A Controlled Pharmacokinetic Evaluation of Tizanidine and Baclofen at Steady State
Drug Metab Dispos 1999 27: 201-204. [Abstract] [Full Text] [PDF]

N. Takenaga, M. Ishii, S. Nakajima, T. Hasegawa, R. Iwasa, H. Ishizaki, and T. Kamei: In Vivo Metabolism of a New Anticancer Agent, 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-( $beta$ -D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506) in Rats and Dogs: Pharmacokinetics, Isolation, Identification, and Quantification of Metabolites
Drug Metab Dispos 1999 27: 205-212. [Abstract] [Full Text] [PDF]

N. Takenaga, T. Hasegawa, M. Ishii, H. Ishizaki, S. Hata, and T. Kamei: In Vitro Metabolism of a New Anticancer Agent, 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-( $beta$ -D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506), in Mice, Rats, Dogs, and Humans
Drug Metab Dispos 1999 27: 213-220. [Abstract] [Full Text] [PDF]

Kye S. Han and Myung G. Lee: Pharmacokinetics of a Chemoprotective Agent, 2-(Allylthio)pyrazine, after Intravenous and Oral Administration to Rats: Hepatic and Gastric First-Pass Effects
Drug Metab Dispos 1999 27: 221-226. [Abstract] [Full Text] [PDF]

Ulrika S. H. Svensson, Rikard Sandström, Örjan Carlborg, Hans Lennernäs, and Michael Ashton: High In Situ Rat Intestinal Permeability of Artemisinin Unaffected by Multiple Dosing and with No Evidence of P-glycoprotein Involvement
Drug Metab Dispos 1999 27: 227-232. [Abstract] [Full Text] [PDF]

Raymond P. Lee and Poh-Gek Forkert: Inactivation of Cytochrome P-450 (CYP2E1) and Carboxylesterase (Hydrolase A) Enzymes by Vinyl Carbamate in Murine Pulmonary Microsomes
Drug Metab Dispos 1999 27: 233-239. [Abstract] [Full Text] [PDF]

C. R. Calabrese, P. M. Loadman, L. S. E. Lim, M. C. Bibby, J. A. Double, J. E. Brown, and J. H. Lamb: In Vivo Metabolism of the Antitumor Imidazoacridinone C1311 in the Mouse and In Vitro Comparison with Humans
Drug Metab Dispos 1999 27: 240-245. [Abstract] [Full Text] [PDF]

William F. Busby, Jr., Joseph M. Ackermann, and Charles L. Crespi: Effect of Methanol, Ethanol, Dimethyl Sulfoxide, and Acetonitrile on In Vitro Activities of cDNA-Expressed Human Cytochromes P-450
Drug Metab Dispos 1999 27: 246-249. [Abstract] [Full Text] [PDF]

Jean-Marie Nicolas, Philippe Collart, Brigitte Gerin, Gary Mather, William Trager, Rene Levy, and Jose Roba: In Vitro Evaluation of Potential Drug Interactions With Levetiracetam, A New Antiepileptic Agent
Drug Metab Dispos 1999 27: 250-254. [Abstract] [Full Text] [PDF]

Edward E. Cable and Harriet C. Isom: Metabolism of 3,5,5-Trimethylhexanoyl-Ferrocene by Rat Liver: Release of Iron from 3,5,5-Trimethylhexanoyl-Ferrocene by a Microsomal, Phenobarbital-Inducible Cytochrome P-450
Drug Metab Dispos 1999 27: 255-260. [Abstract] [Full Text] [PDF]

M. Kimberly Mitchell, Bernard W. Futscher, and Charlene A. McQueen: Developmental Expression of N-Acetyltransferases in C57BI/6 Mice
Drug Metab Dispos 1999 27: 261-264. [Abstract] [Full Text] [PDF]

Brian B. Hasinoff and Ronald G. Aoyama: Relative Plasma Levels of the Cardioprotective Drug Dexrazoxane and Its Two Active Ring-Opened Metabolites in the Rat
Drug Metab Dispos 1999 27: 265-268. [Abstract] [Full Text] [PDF]

Zhaopie Zeng and Nicholas W. Andrew: Characterization of Eprinomectin N-Deacetylase in Rats
Drug Metab Dispos 1999 27: 269-273. [Abstract] [Full Text] [PDF]

Yong Ming Tang, Gen-Fu Chen, Patricia A. Thompson, Dong-Xin Lin, Nicholas P. Lang, and Fred F. Kadlubar: Development of an AntiPeptide Antibody That Binds to the C-Terminal Region of Human CYP1B1
Drug Metab Dispos 1999 27: 274-280. [Abstract] [Full Text] [PDF]

Julie K. Doerr-Stevens, Juping Liu, Gregory J. Stevens, James C. Kraner, Susan M. Fontaine, James R. Halpert, and I. Glenn Sipes: Induction of Cytochrome P-450 Enzymes after Repeated Exposure to 4-Vinylcyclohexene in B6C3F₁ Mice
Drug Metab Dispos 1999 27: 281-287. [Abstract] [Full Text] [PDF]

Martine Bourrié, Viviane Meunier, Yves Berger, and Gérard Fabre: Role of Cytochrome P-4502C9 in Irbesartan Oxidation by Human Liver Microsomes
Drug Metab Dispos 1999 27: 288-296. [Abstract] [Full Text] [PDF]

Sanjeev Kumar, K. Wayne Riggs, and Dan W. Rurak: Role of the Liver and Gut in Systemic Diphenhydramine Clearance in Adult Nonpregnant Sheep
Drug Metab Dispos 1999 27: 297-302. [Abstract] [Full Text] [PDF]

Shoji Kudo, Hiroshi Okumura, Gohachiro Miyamoto, and Takashi Ishizaki: Cytochrome P-450 Isoforms Involved in Carboxylic Acid Ester Cleavage of Hantzsch Pyridine Ester of Pranidipine
Drug Metab Dispos 1999 27: 303-308. [Abstract] [Full Text] [PDF]

Kazuo Okushio, Masayuki Suzuki, Natsuki Matsumoto, Fumio Nanjo, and Yukihiko Hara: Identification of ( $-$ )-Epicatechin Metabolites and Their Metabolic Fate in the Rat
Drug Metab Dispos 1999 27: 309-316. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Theoretical mechanisms for the decreased bioavailability of artemisinin after multiple administration (ART,artemisinin) in rats. Inset A shows the increased efflux of artemisinininto the lumen due to induction of carrier-mediated transportproteins, decreased passive diffusion, and increased metabolismassociated with induction. Inset B shows decreased protein binding.Inset C diagrams increased hepatocellular capacity due to inductionof enzymes via increased transcription (1), mRNA stabilization(2), increased translation (3), or protein stabilization/activation(4). See the article by Svensson et al. on page 227 in thisissue.