Noab BioDiscoveries - Shaping Drug Discovery

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April 1999; 27 (4)   [Index by Author]  [Cover Caption]
       Articles
       Short Communications
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Articles:

Peter J. Deisinger and J. Caroline English
Bioavailability and Metabolism of Hydroquinone after Intratracheal Instillation in Male Rats
Drug Metab Dispos 1999 27: 442-448. [Abstract] [Full Text] [PDF]  

Sébastien J. Provencher, Christian Demers, Marie-Claude Bastien, Jean-Pierre Villeneuve, and Marielle Gascon-Barré
Effect of Cyclosporine A on Cytochrome P-450-Mediated Drug Metabolism in the Partially Hepatectomized Rat
Drug Metab Dispos 1999 27: 449-455. [Abstract] [Full Text] [PDF]  

Erich Wolz, Hans Liechti, Brigitte Notter, Gottfried Oesterhelt, and Andreas Kistler
Characterization of Metabolites of Astaxanthin in Primary Cultures of Rat Hepatocytes
Drug Metab Dispos 1999 27: 456-462. [Abstract] [Full Text] [PDF]  

Sanjeev Kumar, K. Wayne Riggs, and Dan W. Rurak
Comparative Formation, Distribution, and Elimination Kinetics of Diphenylmethoxyacetic Acid (a Diphenhydramine Metabolite) in Maternal and Fetal Sheep
Drug Metab Dispos 1999 27: 463-470. [Abstract] [Full Text] [PDF]  

Michael Meger, Elmar Richter, Wolfgang Zwickenpflug, Christiana Oehlmann, Maureen B. Hargaden, Yousif I. A-Rahim, and Elliot S. Vesell
Metabolism and Disposition of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) in Rhesus Monkeys
Drug Metab Dispos 1999 27: 471-478. [Abstract] [Full Text] [PDF]  

S. Y. Zhou, D. Fleisher, L. H. Pao, C. Li, B. Winward, and E. M. Zimmermann
Intestinal Metabolism and Transport of 5-Aminosalicylate
Drug Metab Dispos 1999 27: 479-485. [Abstract] [Full Text] [PDF]  

Min-Hsiung Pan, Tsang-Miao Huang, and Jen-Kun Lin
Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice
Drug Metab Dispos 1999 27: 486-494. [Abstract] [Full Text] [PDF]  

Yoshihiko Tagawa, Kiyoshi Miwa, Ryoichi Tsukuda, Yoshinobu Yoshimura, Shigeharu Tanayama, and Yusuke Tanigawara
Effect of Its Demethylated Metabolite on the Pharmacokinetics of Unchanged Tak-603, A New Antirheumatic Agent, in Rats
Drug Metab Dispos 1999 27: 495-501. [Abstract] [Full Text] [PDF]  

Patrick S.-Y. Wong and Jon M. Fukuto
Reaction of Organic Nitrate Esters and S-Nitrosothiols With Reduced Flavins: A Possible Mechanism of Bioactivation
Drug Metab Dispos 1999 27: 502-509. [Abstract] [Full Text] [PDF]  

Minsun Baek, Hak Soon Chung, Yunje Kim, and Dong-Hyun Kim
Disposition and Metabolism of 2-(2"(1",3"-Dioxolan-2-Yl)-2-Methyl-4-(2'-Oxopyrrolidin-1-Yl)-6-Nitro-2h-1-Benzopyran (skp-450) in Rats
Drug Metab Dispos 1999 27: 510-516. [Abstract] [Full Text] [PDF]  

David M. Stresser and David Kupfer
Monospecific Antipeptide Antibody to Cytochrome P-450 2B6
Drug Metab Dispos 1999 27: 517-525. [Abstract] [Full Text] [PDF]  

David J. Carlile, Nancy Hakooz, and J. Brian Houston
Kinetics of Drug Metabolism in Rat Liver Slices: IV. Comparison of Ethoxycoumarin Clearance by Liver Slices, Isolated Hepatocytes, and Hepatic Microsomes from Rats Pretreated with Known Modifiers of Cytochrome P-450 Activity
Drug Metab Dispos 1999 27: 526-532. [Abstract] [Full Text] [PDF]  

Camille P. Granvil, Ajay Madan, Mahmoud Sharkawi, Andrew Parkinson, and Irving W. Wainer
Role of CYP2B6 and CYP3A4 in the In Vitro N-Dechloroethylation of (R)- and (S)-Ifosfamide in Human Liver Microsomes
Drug Metab Dispos 1999 27: 533-541. [Abstract] [Full Text] [PDF]  

Brian S. Cummings, Richard C. Zangar, Raymond F. Novak, and Lawrence H. Lash
Cellular Distribution of Cytochromes P-450 in the Rat Kidney
Drug Metab Dispos 1999 27: 542-548. [Abstract] [Full Text] [PDF]  

Jian-Ya Huan and Dennis R. Koop
Tightly Regulated and Inducible Expression of Rabbit Cyp2e1 Using A Tetracycline-Controlled Expression System
Drug Metab Dispos 1999 27: 549-554. [Abstract] [Full Text] [PDF]  

Short Communications:

Mohammad A. Tabrizi-Fard, Tristan S. Maurer, and Ho-Leung Fung
In Vivo Disposition of 3-Nitro-L-Tyrosine in Rats: Implications on Tracking Systemic Peroxynitrite Exposure
Drug Metab Dispos 1999 27: 429-431. [Abstract] [Full Text] [PDF]  

James Meyer, Marvin C. Meyer, and Allyn L. Golub
Pharmacokinetics of Aminolevulinic Acid after Oral and Intravenous Administration in Dogs
Drug Metab Dispos 1999 27: 432-435. [Abstract] [Full Text] [PDF]  

Leonard V. Favreau, Jairam R. Palamanda, Chin-chung Lin, and Amin A. Nomeir
Improved Reliability of the Rapid Microtiter Plate Assay Using Recombinant Enzyme in Predicting CYP2D6 Inhibition in Human Liver Microsomes
Drug Metab Dispos 1999 27: 436-439. [Abstract] [Full Text] [PDF]  

Xiao-Yan Chu, Yukio Kato, and Yuichi Sugiyama
Possible Involvement of P-Glycoprotein in Biliary Excretion of CPT-11 in Rats
Drug Metab Dispos 1999 27: 440-441. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Influence of DEX, 3-MC, acetone, PB, and beta NF administration (lines 1 to 6 respectively) on the levels of mRNA of each CYP transcript. Left side shows representative Northern analyses. Right side shows densitometric evaluation of the CYP/18S ratios. See the article by Provencher et al. on page 449 of this issue.



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