Noab BioDiscoveries - Shaping Drug Discovery

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January 2000; 28 (1)   [Index by Author]  [Cover Caption]
       Articles
       Short Communications
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To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Martin Schwahn, Hubert Schupke, Antje Gasparic, Dorothee Krone, Gernot Peter, Roland Hempel, Thomas Kronbach, Mathias Locher, Wolfgang Jahn, and Jürgen Engel
Disposition and Metabolism of Cetrorelix, A Potent Luteinizing Hormone-Releasing Hormone Antagonist, in Rats and Dogs
Drug Metab Dispos 2000 28: 10-20. [Abstract] [Full Text] [PDF]  

Masao Sato, Hiroaki Suzaka, and Hiroshi Miyazaki
SEX-Related Differences in Urinary Excretion of Egualen Sodium in Rats
Drug Metab Dispos 2000 28: 21-27. [Abstract] [Full Text] [PDF]  

Evan D. Kharasch, Douglas C. Hankins, and Julie K. Taraday
Single-Dose Methoxsalen Effects on Human Cytochrome P-450 2A6 Activity
Drug Metab Dispos 2000 28: 28-33. [Abstract] [Full Text] [PDF]  

Katalin Jemnitz, Zsuzsa Veres, Katalin Monostory, and László Vereczkey
Glucuronidation of Thyroxine in Primary Monolayer Cultures of Rat Hepatocytes: In Vitro Induction of UDP-Glucuronosyltranferases by Methylcholanthrene, Clofibrate, and Dexamethasone Alone and in Combination
Drug Metab Dispos 2000 28: 34-37. [Abstract] [Full Text] [PDF]  

Jairam Palamanda, Wei-Wei Feng, Chin-Chung Lin, and Amin A. Nomeir
Stimulation of Tolbutamide Hydroxylation by Acetone and Acetonitrile in Human Liver Microsomes and in a Cytochrome P-450 2C9-Reconstituted System
Drug Metab Dispos 2000 28: 38-43. [Abstract] [Full Text] [PDF]  

Marie Roumi, Sylvie Marleau, Patrick du Souich, Tony Maggi, Romano Deghenghi, and Huy Ong
Kinetics and Disposition of Hexarelin, A Peptidic Growth Hormone Secretagogue, in Rats
Drug Metab Dispos 2000 28: 44-50. [Abstract] [Full Text] [PDF]  

Lydiane Pichard-Garcia, Ruth Hyland, Jean Baulieu, Jean-Michel Fabre, Ashley Milton, and Patrick Maurel
Human Hepatocytes in Primary Culture Predict Lack of Cytochrome P-450 3A4 Induction by Eletriptan In Vivo
Drug Metab Dispos 2000 28: 51-57. [Abstract] [Full Text] [PDF]  

Angela Äbelö, Tommy B. Andersson, Ulf Bredberg, Inger Skånberg, and Lars Weidolf
Stereoselective Metabolism by Human Liver CYP Enzymes of A Substituted Benzimidazole
Drug Metab Dispos 2000 28: 58-64. [Abstract] [Full Text] [PDF]  

N. Piyapolrungroj, Y. S. Zhou, C. Li, G. Liu, E. Zimmermann, and D. Fleisher
Cimetidine Absorption and Elimination in Rat Small Intestine
Drug Metab Dispos 2000 28: 65-72. [Abstract] [Full Text] [PDF]  

Shin-ichiro Kuriya, Shigeru Ohmori, Mayuko Hino, Itsuko Ishii, Hiroyoshi Nakamura, Chiaki Senda, Takashi Igarashi, Masahiro Kiuchi, and Mitsukazu Kitada
Identification of Cytochrome P-450 Isoform(s) Responsible for the Metabolism of Pimobendan in Human Liver Microsomes
Drug Metab Dispos 2000 28: 73-78. [Abstract] [Full Text] [PDF]  

H. Davi, C. Tronquet, G. Miscoria, L. Perrier, P. DuPont, J. Caix, J. Simiand, and Y. Berger
Disposition of Irbesartan, an Angiotensin II AT1-Receptor Antagonist, in Mice, Rats, Rabbits, and Macaques
Drug Metab Dispos 2000 28: 79-88. [Abstract] [Full Text] [PDF]  

Kamlesh P. Vyas, Rita A. Halpin, Leslie A. Geer, Joan D. Ellis, Lida Liu, Haiyung Cheng, Cynthia Chavez-Eng, Bogdan K. Matuszewski, Sandor L. Varga, Alexander R. Guiblin, and J. D. Rogers
Disposition and Pharmacokinetics of the Antimigraine Drug, Rizatriptan, in Humans
Drug Metab Dispos 2000 28: 89-95. [Abstract] [Full Text] [PDF]  

Joanna L. Harvey, Alan J. Paine, Patrick Maurel, and Matthew C. Wright
Effect of the Adrenal 11-beta -Hydroxylase Inhibitor Metyrapone on Human Hepatic Cytochrome P-450 Expression: Induction of Cytochrome P-450 3A4
Drug Metab Dispos 2000 28: 96-101. [Abstract] [Full Text] [PDF]  

Short Communications:

Sherry R. Black and James M. Mathews
Short Communication: Metabolism and Disposition of 4-t-Butylcatechol in Rats and Mice
Drug Metab Dispos 2000 28: 1-4. [Abstract] [Full Text] [PDF]  

Stephen S. Hecht, Neil Trushin, Saranjit K. Chhabra, Lucy M. Anderson, and Pratibha V. Nerurkar
Short Communication: Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by Cultured Monkey Lung Explants
Drug Metab Dispos 2000 28: 5-9. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

Structural formula and amino acid sequence of (D-4-chloro[ring-U-14C] Phe)cetrorelix, a potent luteinizing hormone-releasing hormone (LH-RH)2 receptor antagonist free of edematogenic side effects. See the article by Schwahn et al. on page 10 of this issue.



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