Articles:

Yea-Huey Yang, Cristobal L. Miranda, Marilyn C. Henderson, Jun-Lan Wang-Buhler, and Donald R. Buhler

Heterologous Expression of Cyp2k1 and Identification of the Expressed Protein (bv-Cyp2k1) As Lauric Acid (-1)-Hydroxylase and Aflatoxin B1 exo-Epoxidase
Drug Metab Dispos 2000 28: 1279-1283. [Abstract] [Full Text] [PDF]  

Henk H. Thijssen, Jean-Pierre Flinois, and Phillippe H. Beaune

Cytochrome P4502C9 Is the Principal Catalyst of Racemic Acenocoumarol Hydroxylation Reactions in Human Liver Microsomes
Drug Metab Dispos 2000 28: 1284-1290. [Abstract] [Full Text] [PDF]  

Tamihide Matsunaga, Nobuyuki Kishi, Shinsuke Higuchi, Kazuhito Watanabe, Tohru Ohshima, and Ikuo Yamamoto

CYP3A4 Is a Major Isoform Responsible for Oxidation of 7-Hydroxy-⁸-tetrahydrocannabinol to 7-Oxo-⁸-tetrahydrocannabinol in Human Liver Microsomes
Drug Metab Dispos 2000 28: 1291-1296. [Abstract] [Full Text] [PDF]  

Cristobal L. Miranda, Yea-Huey Yang, Marilyn C. Henderson, Jan F. Stevens, Gilberto Santana-Rios, Max L. Deinzer, and Donald R. Buhler

Prenylflavonoids from Hops Inhibit the Metabolic Activation of the Carcinogenic Heterocyclic Amine 2-Amino-3-methylimidazo[4,5-f]quinoline, Mediated by cDNA-Expressed Human CYP1A2
Drug Metab Dispos 2000 28: 1297-1302. [Abstract] [Full Text] [PDF]  

Katsuhiro Ohyama, Miki Nakajima, Sumika Nakamura, Noriaki Shimada, Hiroshi Yamazaki, and Tsuyoshi Yokoi

A Significant Role of Human Cytochrome P450 2C8 in Amiodarone N-Deethylation: An Approach to Predict the Contribution with Relative Activity Factor
Drug Metab Dispos 2000 28: 1303-1310. [Abstract] [Full Text] [PDF]  

Qiang Xie, Qing-Yu Zhang, Yan Zhang, Ting Su, Jun Gu, Laurence S. Kaminsky, and Xinxin Ding

Induction of Mouse CYP2J by Pyrazole in the Eye, Kidney, Liver, Lung, Olfactory Mucosa, and Small Intestine, but Not in the Heart
Drug Metab Dispos 2000 28: 1311-1316. [Abstract] [Full Text] [PDF]  

François A. Leblond, Lise Giroux, Jean-Pierre Villeneuve, and Vincent Pichette

Decreased in Vivo Metabolism of Drugs in Chronic Renal Failure
Drug Metab Dispos 2000 28: 1317-1320. [Abstract] [Full Text] [PDF]  

María Teresa Donato, Pirkko Viitala, Cristina Rodriguez-Antona, Aija Lindfors, Jose V. Castell, Hannu Raunio, Maria Jose Gómez-Lechón, and Olavi Pelkonen

CYP2A5/CYP2A6 Expression in Mouse and Human Hepatocytes Treated with Various in Vivo Inducers
Drug Metab Dispos 2000 28: 1321-1326. [Abstract] [Full Text] [PDF]  

Dermot F. McGinnity, Alison J. Parker, Matthew Soars, and Robert J. Riley

Automated Definition of the Enzymology of Drug Oxidation by the Major Human Drug Metabolizing Cytochrome P450s
Drug Metab Dispos 2000 28: 1327-1334. [Abstract] [Full Text] [PDF]  

S. Billecke, D. Draganov, R. Counsell, P. Stetson, C. Watson, C. Hsu, and B. N. La Du

Human Serum Paraoxonase (pon1) Isozymes Q and R Hydrolyze Lactones and Cyclic Carbonate Esters
Drug Metab Dispos 2000 28: 1335-1342. [Abstract] [Full Text] [PDF]  

Wolfgang Jacobsen, Uwe Christians, and Leslie Z. Benet

In Vitro Evaluation of the Disposition of A Novel Cysteine Protease Inhibitor
Drug Metab Dispos 2000 28: 1343-1351. [Abstract] [Full Text] [PDF]  

Qing Ren, Sharon E. Murphy, Zhong Zheng, and Philip Lazarus

O-Glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1- (3-Pyridyl)-1-Butanol (nnal) by Human Udp-Glucuronosyltransferases 2b7 and 1a9
Drug Metab Dispos 2000 28: 1352-1360. [Abstract] [Full Text] [PDF]  

Tomoko Komatsu, Hiroshi Yamazaki, Satoru Asahi, Elizabeth M. J. Gillam, F. Peter Guengerich, Miki Nakajima, and Tsuyoshi Yokoi

Formation of A Dihydroxy Metabolite of Phenytoin in Human Liver Microsomes/cytosol: Roles of Cytochromes P450 2c9, 2c19, and 3a4
Drug Metab Dispos 2000 28: 1361-1368. [Abstract] [Full Text] [PDF]  

Wolfgang Jacobsen, Bernd Kuhn, Andrea Soldner, Gabriele Kirchner, Karl-Fr. Sewing, Peter A. Kollman, Leslie Z. Benet, and Uwe Christians

Lactonization Is the Critical First Step in the Disposition of the 3-Hydroxy-3-Methylglutaryl-Coa Reductase Inhibitor Atorvastatin
Drug Metab Dispos 2000 28: 1369-1378. [Abstract] [Full Text] [PDF]  

Pierre Allain, Oliver Heudi, Annie Cailleux, Anne Le Bouil, Francis Larra, Michele Boisdron-Celle, and Erik Gamelin

Early Biotransformations of Oxaliplatin after Its Intravenous Administration to Cancer Patients
Drug Metab Dispos 2000 28: 1379-1384. [Abstract] [Full Text] [PDF]  

Pia Lautala, Brian T. Ethell, Jyrki Taskinen, and Brian Burchell

The Specificity of Glucuronidation of Entacapone and Tolcapone by Recombinant Human Udp-Glucuronosyltransferases
Drug Metab Dispos 2000 28: 1385-1389. [Abstract] [Full Text] [PDF]  

Short Communications:

Sharon E. Murphy, Issa S. Isaac, Xinxin Ding, and Edward J. McIntee

Specificity of Cytochrome P450 2A3-Catalyzed -Hydroxylation of N'-Nitrosonornicotine Enantiomers
Drug Metab Dispos 2000 28: 1263-1266. [Abstract] [Full Text] [PDF]  

F. Berlioz, B. Lepére-Prevot, S. Julien, A. Tsocas, C. Carbon, C. Rozé, and R. Farinotti

Chronic Nifedipine Dosing Enhances Cephalexin Bioavailability and Intestinal Absorption in Conscious Rats
Drug Metab Dispos 2000 28: 1267-1269. [Abstract] [Full Text] [PDF]  

Raman Venkataramanan, Vinod Ramachandran, Bernard J. Komoroski, Shimin Zhang, Paul L. Schiff, and Stephen C. Strom

Milk Thistle, a Herbal Supplement, Decreases the Activity of CYP3A4 and Uridine Diphosphoglucuronosyl Transferase in Human Hepatocyte Cultures
Drug Metab Dispos 2000 28: 1270-1273. [Abstract] [Full Text] [PDF]  

Suresh K. Balani, Xin Xu, Byron H. Arison, Maria V. Silva, Amy Gries, Florencia A. DeLuna, Donghui Cui, Prasad H. Kari, Trung Ly, Cornelis E. C. A. Hop, Rominder Singh, Michael A. Wallace, Dennis C. Dean, Jiunn H. Lin, Paul G. Pearson, and Thomas A. Baillie

Metabolites of Caspofungin Acetate, a Potent Antifungal Agent, in Human Plasma and Urine
Drug Metab Dispos 2000 28: 1274-1278. [Abstract] [Full Text] [PDF]  

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