Articles:

Haijun Dong, Robert L. Haining, Kenneth E. Thummel, Allan E. Rettie, and Sidney D. Nelson

Involvement of Human Cytochrome P450 2D6 in the Bioactivation of Acetaminophen
Drug Metab Dispos 2000 28: 1397-1400. [Abstract] [Full Text] [PDF]  

Angelo Mancinelli, Antonio Longo, Roger L. Nation, and Allan M. Evans

Disposition of L-Carnitine and Its Short-Chain Esters, Acetyl-L-carnitine and Propionyl-L-carnitine, in the Rat Isolated Perfused Liver
Drug Metab Dispos 2000 28: 1401-1404. [Full Text] [PDF]  

Marianne Reist, Marieke Roy-de Vos, Jean-Pierre Montseny, Joachim M. Mayer, Pierre-Alain Carrupt, Yves Berger, and Bernard Testa

Very Slow Chiral Inversion of Clopidogrel in Rats: A Pharmacokinetic and Mechanistic Investigation
Drug Metab Dispos 2000 28: 1405-1410. [Abstract] [Full Text] [PDF]  

Jasper Dingemanse, Michele Bury, Yasmin Hussain, and Paul van Giersbergen

Comparative Tolerability, Pharmacodynamics, and Pharmacokinetics of a Metabolite of a Quinolizinone Hypnotic and Zolpidem in Healthy Subjects
Drug Metab Dispos 2000 28: 1411-1416. [Abstract] [Full Text] [PDF]  

Ken Umehara, Shoji Kudo, Yukihiro Hirao, Seiji Morita, Tadaaki Ohtani, Minoru Uchida, and Gohachiro Miyamoto

In Vitro Characterization of the Oxidative Cleavage of the Octyl Side Chain of Olanexidine, a Novel Antimicrobial Agent, in Dog Liver Microsomes
Drug Metab Dispos 2000 28: 1417-1424. [Abstract] [Full Text] [PDF]  

David W. Hein, Charlene A. McQueen, Denis M. Grant, Geoffrey H. Goodfellow, Fred F. Kadlubar, and Wendell W. Weber

Pharmacogenetics of the Arylamine N-Acetyltransferases: A Symposium in Honor of Wendell W. Weber
Drug Metab Dispos 2000 28: 1425-1432. [Abstract] [Full Text] [PDF]  

E. Stacy Ward, Gary M. Pollack, and Kim L. R. Brouwer

Probenecid-Associated Alterations in Valproic Acid Pharmacokinetics in Rats: Can in Vivo Disposition of Valproate Glucuronide Be Predicted from in Vitro Formation Data?
Drug Metab Dispos 2000 28: 1433-1439. [Abstract] [Full Text] [PDF]  

David M. Stresser, Andrew P. Blanchard, Stephanie D. Turner, John C. L. Erve, Andre A. Dandeneau, Vaughn P. Miller, and Charles L. Crespi

Substrate-Dependent Modulation of CYP3A4 Catalytic Activity: Analysis of 27 Test Compounds with Four Fluorometric Substrates
Drug Metab Dispos 2000 28: 1440-1448. [Abstract] [Full Text] [PDF]  

Shufeng Zhou, James W. Paxton, Malcolm D. Tingle, and Philip Kestell

Identification of the Human Liver Cytochrome P450 Isoenzyme Responsible for the 6-Methylhydroxylation of the Novel Anticancer Drug 5,6-Dimethylxanthenone-4-acetic Acid
Drug Metab Dispos 2000 28: 1449-1456. [Abstract] [Full Text] [PDF]  

Tomoko Komatsu, Hiroshi Yamazaki, Noriaki Shimada, Miki Nakajima, and Tsuyoshi Yokoi

Roles of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes
Drug Metab Dispos 2000 28: 1457-1463. [Abstract] [Full Text] [PDF]  

Deanna L. Hubbard, Diana G. Wilkins, and Douglas E. Rollins

The Incorporation of Cocaine and Metabolites into Hair: Effects of Dose and Hair Pigmentation
Drug Metab Dispos 2000 28: 1464-1469. [Abstract] [Full Text] [PDF]  

Tamara Vanhaecke, Kai O. Lindros, Teija Oinonen, Antoine Vercruysse, and Vera Rogiers

Effect of Long-Term Ethanol Exposure on the Acinar Distribution of Hepatic Glutathione S-Transferase
Drug Metab Dispos 2000 28: 1470-1474. [Abstract] [Full Text] [PDF]  

Ge Lin, Yan-Yan Cui, and Edward M. Hawes

Characterization of Rat Liver Microsomal Metabolites of Clivorine, an Hepatotoxic Otonecine-Type Pyrrolizidine Alkaloid
Drug Metab Dispos 2000 28: 1475-1483. [Abstract] [Full Text] [PDF]  

Naotoshi Yamamura, Kaoru Imura-Miyoshi, and Hideo Naganuma

Panipenum, A Carbapenem Antibiotic, Increases the Level of Hepatic Udp-Glucuronic Acid in Rats
Drug Metab Dispos 2000 28: 1484-1486. [Abstract] [Full Text] [PDF]  

Shizuo Yamada, Takashi Okura, Ryohei Kimura, Yoshiharu Deguchi, Yasunori Suzuki, Takuo Kobayashi, and Kazuo Aisaka

Disposition and ₁-Adrenoceptor Binding Characteristics of JTH-601 and Its Metabolites in Rat Tissues
Drug Metab Dispos 2000 28: 1487-1492. [Abstract] [Full Text] [PDF]  

Karthik Venkatakrishnan, Lisa L. von Moltke, Michael H. Court, Jerold S. Harmatz, Charles L. Crespi, and David J. Greenblatt

Comparison between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from cDNA-Expressed CYPs to Human Liver Microsomes: Ratios of Accessory Proteins as Sources of Discrepancies between the Approaches
Drug Metab Dispos 2000 28: 1493-1504. [Abstract] [Full Text] [PDF]  

Lida Antonian, Hongbing Zhang, Cheng Yang, Greg Wagner, Laura K. Shawver, Manjunath Shet, Brian Ogilvie, Ajay Madan, and Andrew Parkinson

Biotransformation of the Anti-Angiogenic Compound SU5416
Drug Metab Dispos 2000 28: 1505-1512. [Abstract] [Full Text] [PDF]  

Vladimír Kren, Jitka Ulrichová, Pavel Kosina, David Stevenson, Petr Sedmera, Vera Prikrylová, Petr Halada, and Vilím Simánek

Chemoenzymatic Preparation of Silybin -Glucuronides and Their Biological Evaluation
Drug Metab Dispos 2000 28: 1513-1517. [Abstract] [Full Text] [PDF]  

Yoshihiro Shibata, Hiroyuki Takahashi, and Yasuyuki Ishii

A Convenient In Vitro Screening Method for Predicting In Vivo Drug Metabolic Clearance Using Isolated Hepatocytes Suspended in Serum
Drug Metab Dispos 2000 28: 1518-1523. [Abstract] [Full Text] [PDF]  

Jennifer Venhorst, Rob C. A. Onderwater, John H. N. Meerman, Jan N. M. Commandeur, and Nico P. E. Vermeulen

Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity
Drug Metab Dispos 2000 28: 1524-1532. [Abstract] [Full Text] [PDF]  

Short Communications:

Nathalie Ledirac, Georges de Sousa, Franck Fontaine, Constantin Agouridas, Jean Gugenheim, Giocando Lorenzon, and Roger Rahmani

Effects of Macrolide Antibiotics on CYP3A Expression in Human and Rat Hepatocytes: Interspecies Differences in Response to Troleandomycin
Drug Metab Dispos 2000 28: 1391-1393. [Abstract] [Full Text] [PDF]  

Jan Van Gelder, Sven Deferme, Pieter Annaert, Lieve Naesens, Erik De Clercq, Guy Van den Mooter, Renaat Kinget, and Parick Augustijns

Increased Absorption of the Antiviral Ester Prodrug Tenofovir Disoproxil in Rat Ileum by Inhibiting Its Intestinal Metabolism
Drug Metab Dispos 2000 28: 1394-1396. [Abstract] [Full Text] [PDF]  

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