DMD -- Table of Contents (28 [3])

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March 2000; 28 (3)   [Index by Author] [Cover Caption]

       Editorial

       Reviews

       Articles

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Editorial:

James R. Halpert: Editorial
Drug Metab Dispos 2000 28: 245. [Full Text] [PDF]

Reviews:

J. Brian Houston and Kathryn E. Kenworthy: In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
Drug Metab Dispos 2000 28: 246-254. [Abstract] [Full Text] [PDF]

Articles:

W. George Lai, Iain Gardner, Nasir Zahid, and Jack P. Uetrecht: Bioactivation and Covalent Binding of Hydroxyfluperlapine in Human Neutrophils: Implications for Fluperlapine-Induced Agranulocytosis
Drug Metab Dispos 2000 28: 255-263. [Abstract] [Full Text] [PDF]

Judith van Asperen, Olaf van Tellingen, and Jos H. Beijnen: The Role of mdr1a P-Glycoprotein in the Biliary and Intestinal Secretion of Doxorubicin and Vinblastine in Mice
Drug Metab Dispos 2000 28: 264-267. [Abstract] [Full Text] [PDF]

Erin G. Schuetz, Wolfgang Schmid, Gunther Schutz, Cynthia Brimer, Kazuto Yasuda, Tetsuya Kamataki, Lester Bornheim, Kathy Myles, and Timothy J. Cole: The Glucocorticoid Receptor Is Essential for Induction of Cytochrome P-4502B by Steroids but Not for Drug or Steroid Induction of CYP3A or P-450 Reductase in Mouse Liver
Drug Metab Dispos 2000 28: 268-278. [Abstract] [Full Text] [PDF]

Sanjeev Kumar, George R. Tonn, K. Wayne Riggs, and Dan W. Rurak: Diphenhydramine Disposition in the Sheep Maternal-Placental-Fetal Unit: Gestational Age, Plasma Drug Protein Binding, and Umbilical Blood Flow Effects on Clearance
Drug Metab Dispos 2000 28: 279-285. [Abstract] [Full Text] [PDF]

Peter R. Stout, David J. Claffey, and James A. Ruth: Incorporation and Retention of Radiolabeled S-(+)-and R-( $-$ )-Methamphetamine and S(+)- and R( $-$ )-N-(n-butyl)-amphetamine in Mouse Hair after Systemic Administration
Drug Metab Dispos 2000 28: 286-291. [Abstract] [Full Text] [PDF]

Qing-Yu Zhang, Deborah Dunbar, and Laurence Kaminsky: Human Cytochrome P-450 Metabolism of Retinals to Retinoic Acids
Drug Metab Dispos 2000 28: 292-297. [Abstract] [Full Text] [PDF]

Daniel R. Doerge, Hebron C. Chang, Mona I. Churchwell, and C. Lee Holder: Analysis of Soy Isoflavone Conjugation In Vitro and in Human Blood Using Liquid Chromatography-Mass Spectrometry
Drug Metab Dispos 2000 28: 298-307. [Abstract] [Full Text] [PDF]

Susan K. Paulson, Jeremy D. Hribar, Norman W. K. Liu, Elisabeth Hajdu, Roy H. Bible, Jr., Antoni Piergies, and Aziz Karim: Metabolism and Excretion of [¹⁴C]Celecoxib in Healthy Male Volunteers
Drug Metab Dispos 2000 28: 308-314. [Abstract] [Full Text] [PDF]

Hao Chen, William N. Howald, and Mont R. Juchau: Biosynthesis Of All-trans-Retinoic Acid from All-trans-Retinol: Catalysis of All-trans-Retinol Oxidation by Human P-450 Cytochromes
Drug Metab Dispos 2000 28: 315-322. [Abstract] [Full Text] [PDF]

Gilberto Castañeda-Hernández, Josep Vergés, Vincent Pichette, Lucie Héroux, Gilles Caillé, and Patrick du Souich: Input Rate as a Major Determinant of Furosemide Pharmacodynamics: Influence of Fluid Replacement and Hypoalbuminemia
Drug Metab Dispos 2000 28: 323-328. [Abstract] [Full Text] [PDF]

Lei Zhang, Wenche Gorset, Carla B. Washington, Terrence F. Blaschke, Deanna L. Kroetz, and Kathleen M. Giacomini: Interactions of HIV Protease Inhibitors with a Human Organic Cation Transporter in a Mammalian Expression System
Drug Metab Dispos 2000 28: 329-334. [Abstract] [Full Text] [PDF]

Lynn M. Iwamoto, Christine M. Moore, Naomi Fujiwara, Michael J. Christ, Delores M. Gries, and Kenneth T. Nakamura: m-Hydroxy Benzoylecgonine Recovery in Fetal Guinea Pigs
Drug Metab Dispos 2000 28: 335-338. [Abstract] [Full Text] [PDF]

Thomas Kraemer, Joerg Bickeboeller-Friedrich, and Hans H. Maurer: On the Metabolism of the Amphetamine-Derived Antispasmodic Drug Mebeverine: Gas Chromatography-Mass Spectrometry Studies on Rat Liver Microsomes and on Human Urine
Drug Metab Dispos 2000 28: 339-347. [Abstract] [Full Text] [PDF]

Michael Y. L. Law, Matthew H. Slawson, and David E. Moody: Selective Involvement of Cytochrome P450 2D Subfamily in In Vivo 4-Hydroxylation of Amphetamine in Rat
Drug Metab Dispos 2000 28: 348-353. [Abstract] [Full Text] [PDF]

Michael R. Wester, Jerome M. Lasker, Eric F. Johnson, and Judy L. Raucy: CYP2C19 Participates in Tolbutamide Hydroxylation by Human Liver Microsomes
Drug Metab Dispos 2000 28: 354-359. [Abstract] [Full Text] [PDF]

Regina W. Wang, Deborah J. Newton, Nini Liu, William M. Atkins, and Anthony Y. H. Lu: Human Cytochrome P-450 3A4: In Vitro Drug-Drug Interaction Patterns Are Substrate-Dependent
Drug Metab Dispos 2000 28: 360-366. [Abstract] [Full Text] [PDF]

Gilberto N. Carmona, Rebecca A. Jufer, Steven R. Goldberg, David A. Gorelick, Nigel H. Greig, Qian-Sheng Yu, Edward J. Cone, and Charles W. Schindler: Butyrylcholinesterase Accelerates Cocaine Metabolism: In Vitro and In Vivo Effects in Nonhuman Primates and Humans
Drug Metab Dispos 2000 28: 367-371. [Abstract] [Full Text] [PDF]

Cover Caption:

Liver microsomes (5 µg) from individual male glucocorticoid receptor (+/+) and ( $-$ / $-$ ) mice or a (+/+) mouse treated with phenobarbital(PB) were analyzed by immunoblotting with monoclonal antibodiesraised against rat CYP2B (anti-CYP2B 1, 2, and 3, monoclonal antibodiesH8, BE28.2, and BE26.2, respectively) or polyclonal goat antirat CYP2B(4). See the article by Schuetz et al. on page 268 ofthisissue.