DMD -- Table of Contents (28 [5])

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May 2000; 28 (5)   [Index by Author] [Cover Caption]

       Articles

       SHORT COMMUNICATION

       Accelerated Communications

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Articles:

Richard J. Mountfield, Benedicte Kiehr, and Brian A. John: Metabolism, Disposition, Excretion, and Pharmacokinetics of Levormeloxifene, A Selective Estrogen Receptor Modulator, in the Rat
Drug Metab Dispos 2000 28: 503-513. [Abstract] [Full Text] [PDF]

Susan K. Paulson, Ji Y. Zhang, Alan P. Breau, Jeremy D. Hribar, Norman W. K. Liu, Susan M. Jessen, Yvette M. Lawal, J. Nita Cogburn, Christopher J. Gresk, Charles S. Markos, Timothy J. Maziasz, Grant L. Schoenhard, and Earl G. Burton: Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats
Drug Metab Dispos 2000 28: 514-521. [Abstract] [Full Text] [PDF]

Er-jia Wang, Christopher N. Casciano, Robert P. Clement, and William W. Johnson: In Vitro Flow Cytometry Method to Quantitatively Assess Inhibitors of P-Glycoprotein
Drug Metab Dispos 2000 28: 522-528. [Abstract] [Full Text] [PDF]

Üzen Savas, Michael R. Wester, Keith J. Griffin, and Eric F. Johnson: Rabbit Pregnane X Receptor Is Activated by Rifampicin
Drug Metab Dispos 2000 28: 529-537. [Abstract] [Full Text] [PDF]

Shin'ichi Yoshihara, Keisuke Harada, and Shigeru Ohta: Metabolism of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Perfused Rat Liver: Involvement of Hepatic Aldehyde Oxidase as a Detoxification Enzyme
Drug Metab Dispos 2000 28: 538-543. [Abstract] [Full Text] [PDF]

Timothy Schulz-Utermoehl, Robert J. Edwards, and Alan R. Boobis: Affinity and Potency of Proinhibitory Antipeptide Antibodies Against CYP2D6 Is Enhanced using Cyclic Peptides as Immunogens
Drug Metab Dispos 2000 28: 544-551. [Abstract] [Full Text] [PDF]

Dafang Zhong, Xueqing Li, Aimin Wang, Youjun Xu, and Shuodong Wu: Identification of the Metabolites of Roxithromycin in Humans
Drug Metab Dispos 2000 28: 552-559. [Abstract] [Full Text] [PDF]

Michael B. Fisher, Kristina Campanale, Bradley L. Ackermann, Mark VandenBranden, and Steven A. Wrighton: In Vitro Glucuronidation Using Human Liver Microsomes and The Pore-Forming Peptide Alamethicin
Drug Metab Dispos 2000 28: 560-566. [Abstract] [Full Text] [PDF]

Cuyue Tang, Magang Shou, and A. David Rodrigues: Substrate-Dependent Effect of Acetonitrile on Human Liver Microsomal Cytochrome P450 2C9 (CYP2C9) Activity
Drug Metab Dispos 2000 28: 567-572. [Abstract] [Full Text] [PDF]

Kirsten Börner, Jens Kisro, Svenja K. Brüggemann, Wibke Hagenah, Stefan O. Peters, and Thomas Wagner: Metabolism of Ifosfamide to Chloroacetaldehyde Contributes to Antitumor Activity In Vivo
Drug Metab Dispos 2000 28: 573-576. [Abstract] [Full Text] [PDF]

Toshikiro Kimura, Norio Iwasaki, Jun-Ichi Yokoe, Shunji Haruta, Yoshiaki Yokoo, Ken-Ichi Ogawara, and Kazutaka Higaki: Analysis and Prediction of Absorption Profile Including Hepatic First-Pass Metabolism of N-Methyltyramine, A Potent Stimulant of Gastrin Release Present in Beer, after Oral Ingestion in Rats by Gastrointestinal-Transit-Absorption Model
Drug Metab Dispos 2000 28: 577-581. [Abstract] [Full Text] [PDF]

Chiaki Tanaka, Ryosei Kawai, and Malcolm Rowland: Dose-Dependent Pharmacokinetics of Cyclosporin A in Rats: Events in Tissues
Drug Metab Dispos 2000 28: 582-589. [Abstract] [Full Text] [PDF]

Cindy B. Nguyen, Éva Szönyi, Michael D. Sadick, Timothy E. Hotaling, Jose-Luis Mendoza-Ramirez, and Enrique Escandón: Stability and Interactions of Recombinant Human Nerve Growth Factor in Different Biological Matrices: In Vitro and In Vivo Studies
Drug Metab Dispos 2000 28: 590-597. [Abstract] [Full Text] [PDF]

Cindy B. Nguyen, Louise Harris, Éva Szönyi, Sharon A. Baughman, Victoria G. Hale, Noël O. Dybdal, Michael D. Sadick, and Enrique Escandón: Tissue Disposition and Pharmacokinetics of Recombinant Human Nerve Growth Factor after Acute and Chronic Subcutaneous Administration in Monkeys
Drug Metab Dispos 2000 28: 598-607. [Abstract] [Full Text] [PDF]

Dylan P. Hartley and Curtis D. Klaassen: Detection of Chemical-Induced Differential Expression of Rat Hepatic Cytochrome P450 mRNA Transcripts Using Branched DNA Signal Amplification Technology
Drug Metab Dispos 2000 28: 608-616. [Abstract] [Full Text] [PDF]

SHORT COMMUNICATION:

Wafaa El-Sankary, Nick J. Plant, G. Gordon Gibson, and David J. Moore: Regulation of the CYP3A4 Gene by Hydrocortisone and Xenobiotics: Role of the Glucocorticoid and Pregnane X Receptors
Drug Metab Dispos 2000 28: 493-496. [Abstract] [Full Text] [PDF]

Accelerated Communications:

Olivier Barbier, David Turgeon, Caroline Girard, Mitchell D. Green, Thomas R. Tephly, Dean W. Hum, and Alain Bélanger: 3'-azido-3'-deoxythimidine (AZT) is glucuronidated by human UDP-glucuronosyltransferase 2B7 (UGT2B7)
Drug Metab Dispos 2000 28: 497-502. [Abstract] [Full Text] [PDF]

Cover Caption:

Panel A. The diagram illustrates mRNA1- and mRNA2-specific riboprobes and their predicted protection patterns. Probe 1 representsthe 5'-RACE clone isolated from the $lambda$ ZAP kidney expression library(mRNA1) and probe 2 represents the 5'-RACE clone isolated fromthe adaptor-litigated liver cDNA library (mRNA2). Panel B. TheRNase protection assay. The indicated probes were hybridized topoly(A⁺)-enriched RNA before RNase digestion. The protected fragmentswere separated on sequencing gels and analyzed using a Phosphoimager.See the article by Savas et al. on page 529 of thisissue.