DMD Noab BioDiscoveries - Shaping Drug Discovery

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Other Issues:
January 2001; 29 (1)   [Index by Author]  [Cover Caption]
       Articles
       SHORT COMMUNICATION
       Errata
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Articles:

Nisar A. Pampori, Arun K. Agrawal, and Bernard H. Shapiro
Infusion of Gender-Dependent Plasma Growth Hormone Profiles Into Intact Rats: Effects of Subcutaneous, Intraperitoneal, and Intravenous Routes of Rat and Human Growth Hormone on Endogenous Circulating Growth Hormone Profiles and Expression of Sexually Dimorphic Hepatic Cyp Isoforms
Drug Metab Dispos 2001 29: 8-16. [Abstract] [Full Text] [PDF]  

Stephanie R. Mitchell, Marion B. Sewer, Sean S. Kardar, and Edward T. Morgan
Characterization of Cyp4a Induction in Rat Liver by Inflammatory Stimuli: Dependence on Sex, Strain, and Inflammation-Evoked Hypophagia
Drug Metab Dispos 2001 29: 17-22. [Abstract] [Full Text] [PDF]  

Elizabeth A. Dierks, Karen R. Stams, Heng-Keang Lim, Georgia Cornelius, Honglu Zhang, and Simon E. Ball
A Method for the Simultaneous Evaluation of the Activities of Seven Major Human Drug-Metabolizing Cytochrome P450s Using an in Vitro Cocktail of Probe Substrates and Fast Gradient Liquid Chromatography Tandem Mass Spectrometry
Drug Metab Dispos 2001 29: 23-29. [Abstract] [Full Text] [PDF]  

Tashinga E. Bapiro, Ann-Charlotte Egnell, Julia A. Hasler, and Collen M. Masimirembwa
Application of Higher Throughput Screening (HTS) Inhibition Assays to Evaluate the Interaction of Antiparasitic Drugs with Cytochrome P450s
Drug Metab Dispos 2001 29: 30-35. [Abstract] [Full Text] [PDF]  

Kaoru Kobayashi, Mari Kogo, Masayoshi Tani, Noriaki Shimada, Takashi Ishizaki, Satoshi Numazawa, Takemi Yoshida, Toshinori Yamamoto, Yukio Kuroiwa, and Kan Chiba
Role of CYP2C19 in Stereoselective Hydroxylation of Mephobarbital by Human Liver Microsomes
Drug Metab Dispos 2001 29: 36-40. [Abstract] [Full Text] [PDF]  

Richard L. Voorman, N. Ann Payne, Larry C. Wienkers, Michael J. Hauer, and Phillip E. Sanders
Interaction of Delavirdine with Human Liver Microsomal Cytochrome P450: Inhibition of CYP2C9, CYP2C19, and CYP2D6
Drug Metab Dispos 2001 29: 41-47. [Abstract] [Full Text] [PDF]  

Brian T. Ethell, Kevin Beaumont, David J. Rance, and Brian Burchell
Use of Cloned and Expressed Human UDP-Glucuronosyltransferases for the Assessment of Human Drug Conjugation and Identification of Potential Drug Interactions
Drug Metab Dispos 2001 29: 48-53. [Abstract] [Full Text] [PDF]  

Hong Li, Suk-Jae Chung, Dong-Chool Kim, Hyun-Soo Kim, Jong-Wook Lee, and Chang-Koo Shim
The Transport of a Reversible Proton Pump Antagonist, 5,6-Dimethyl-2-(4-Fluorophenylamino)-4-(1-Methyl-1,2,3,4- Tetrahydroisoquinoline-2-yl) Pyrimidine Hydrochloride (YH1885), across Caco-2 Cell Monolayers
Drug Metab Dispos 2001 29: 54-59. [Abstract] [Full Text] [PDF]  

Ramaswamy A. Iyer, James Mitroka, Bimal Malhotra, Samuel Bonacorsi, Jr., Stephen C. Waller, J. Kent Rinehart, Vikram A. Roongta, and Kishin Kripalani
Metabolism of [14C]Omapatrilat, a Sulfhydryl-Containing Vasopeptidase Inhibitor in Humans
Drug Metab Dispos 2001 29: 60-69. [Abstract] [Full Text] [PDF]  

Michael L. Schrag and Larry C. Wienkers
Triazolam Substrate Inhibition: Evidence of Competition for Heme-Bound Reactive Oxygen Within the CYP3A4 Active Site
Drug Metab Dispos 2001 29: 70-75. [Abstract] [Full Text] [PDF]  

Maarten J. Blom, Marjolein Groot Wassink, Helenius J. Kloosterboer, Antwan G. H. Ederveen, Jan G. D. Lambert, and Henk J. Th. Goos
Metabolism of Estradiol, Ethynylestradiol, and Moxestrol in Rat Uterus, Vagina, and Aorta: Influence of Sex Steroid Treatment
Drug Metab Dispos 2001 29: 76-81. [Abstract] [Full Text] [PDF]  

Keith W. Ward, Joel W. Proksch, Mark A. Levy, and Brian R. Smith
Development of an in Vivo Preclinical Screen Model to Estimate Absorption and Bioavailability of Xenobiotics
Drug Metab Dispos 2001 29: 82-88. [Abstract] [Full Text] [PDF]  

SHORT COMMUNICATION:

Masato Chiba, Lixia Jin, William Neway, Joseph P. Vacca, James R. Tata, Kevin Chapman, and Jiunn H. Lin
P450 Interaction with HIV Protease Inhibitors: Relationship between Metabolic Stability, Inhibitory Potency, and P450 Binding Spectra
Drug Metab Dispos 2001 29: 1-3. [Abstract] [Full Text] [PDF]  

Jiangjun Sheng, Zichun Hua, Jiancheng Guo, Michele Caggana, and Xinxin Ding
Identification of a New Human CYP2A Gene Fragment with Close Linkage to CYP2GP1
Drug Metab Dispos 2001 29: 4-7. [Abstract] [Full Text] [PDF]  

Errata:

Akiko Nishino, Yukio Kato, Takashi Igarashi, and Yuichi Sugiyama
Correction to "Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan"
Drug Metab Dispos 2001 29: 89. [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

Sex dependence of CYP4A mRNA induction of LPS and BaSO4 in F344 rat liver and kidney. See the article by Mitchell et al. on page 17 of this issue.



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