DMD Noab BioDiscoveries - Shaping Drug Discovery

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Other Issues:
October 2001; 29 (10)   [Index by Author]  [Cover Caption]
       Articles
       SHORT COMMUNICATION
       Accelerated Communications
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Articles:

Heleen H. DeCory, Kristen M. Piech-Dumas, Shey-Shing Sheu, Howard J. Federoff, and M. W. Anders
Efflux of Glutathione Conjugate of Monochlorobimane from Striatal and Cortical Neurons
Drug Metab Dispos 2001 29: 1256-1262. [Abstract] [Full Text] [PDF]  

Norio Yasui-Furukori, Mats Hidestrand, Edoardo Spina, Gabriella Facciolá, Maria Gabriella Scordo, and Gunnel Tybring
Different Enantioselective 9-Hydroxylation of Risperidone by the Two Human CYP2D6 and CYP3A4 Enzymes
Drug Metab Dispos 2001 29: 1263-1268. [Abstract] [Full Text] [PDF]  

Alison E. M. Vickers, Markus Zollinger, Robert Dannecker, Ronald Tynes, Francis Heitz, and Volker Fischer
In Vitro Metabolism of Tegaserod in Human Liver and Intestine: Assessment of Drug Interactions
Drug Metab Dispos 2001 29: 1269-1276. [Abstract] [Full Text] [PDF]  

Pieter P. Annaert, Ryan Z. Turncliff, Catherine L. Booth, Dhiren R. Thakker, and Kim L. R. Brouwer
P-Glycoprotein-Mediated In Vitro Biliary Excretion in Sandwich-Cultured Rat Hepatocytes
Drug Metab Dispos 2001 29: 1277-1283. [Abstract] [Full Text] [PDF]  

Kazuhiro Kosuge, Yang Jun, Hiroshi Watanabe, Masahiko Kimura, Masahiko Nishimoto, Takashi Ishizaki, and Kyoichi Ohashi
Effects of CYP3A4 Inhibition by Diltiazem on Pharmacokinetics and Dynamics of Diazepam in Relation to CYP2C19 Genotype Status
Drug Metab Dispos 2001 29: 1284-1289. [Abstract] [Full Text] [PDF]  

Sarvesh C. Vashishtha, Edward M. Hawes, Gordon McKay, and Denis J. McCann
Quaternary Ammonium-Linked Glucuronidation of 1-Substituted Imidazoles: Studies of Human UDP-Glucuronosyltransferases Involved and Substrate Specificities
Drug Metab Dispos 2001 29: 1290-1295. [Abstract] [Full Text] [PDF]  

Abdul Mutlib, John Shockcor, Shiang-Yuan Chen, Robert Espina, Jianrong Lin, Nilsa Graciani, Shimoga Prakash, and Liang-Shang Gan
Formation of Unusual Glutamate Conjugates of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]- 4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) and Its Analogs: The Role of gamma -Glutamyltranspeptidase in the Biotransformation of Benzylamines
Drug Metab Dispos 2001 29: 1296-1306. [Abstract] [Full Text] [PDF]  

Cathaleen Shu, Hong Shen, Ulrich Hopfer, and David E. Smith
Mechanism of Intestinal Absorption and Renal Reabsorption of an Orally Active Ace Inhibitor: Uptake and Transport of Fosinopril in Cell Cultures
Drug Metab Dispos 2001 29: 1307-1315. [Abstract] [Full Text] [PDF]  

Yoichi Naritomi, Shigeyuki Terashita, Sumihisa Kimura, Akira Suzuki, Akira Kagayama, and Yuichi Sugiyama
Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans
Drug Metab Dispos 2001 29: 1316-1324. [Abstract] [Full Text] [PDF]  

Lionel Drocourt, Jean-Marc Pascussi, Eric Assenat, Jean-Michel Fabre, Patrick Maurel, and Marie-José Vilarem
Calcium Channel Modulators of the Dihydropyridine Family Are Human Pregnane X Receptor Activators and Inducers of CYP3A, CYP2B, and CYP2C in Human Hepatocytes
Drug Metab Dispos 2001 29: 1325-1331. [Abstract] [Full Text] [PDF]  

J. Cory Kalvass, David A. Tess, Craig Giragossian, Michael C. Linhares, and Tristan S. Maurer
Influence of Microsomal Concentration on Apparent Intrinsic Clearance: Implications for Scaling in Vitro Data
Drug Metab Dispos 2001 29: 1332-1336. [Abstract] [Full Text] [PDF]  

Sanjeev Thohan, MaryLynn C. Zurich, Ho Chung, Myron Weiner, Andrew S. Kane, and Gerald M. Rosen
Tissue Slices Revisited: Evaluation and Development of a Short-Term Incubation for Integrated Drug Metabolism
Drug Metab Dispos 2001 29: 1337-1342. [Abstract] [Full Text] [PDF]  

Ursula Breyer-Pfaff and Helmut Wachsmuth
Tertiary N-Glucuronides of Clozapine and Its Metabolite Desmethylclozapine in Patient Urine
Drug Metab Dispos 2001 29: 1343-1348. [Abstract] [Full Text] [PDF]  

Svetlana Dimova, Peter H. M. Hoet, and Benoit Nemery
Xenobiotic-Metabolizing Enzyme Activities in Primary Cultures of Rat Type II Pneumocytes and Alveolar Macrophages
Drug Metab Dispos 2001 29: 1349-1354. [Abstract] [Full Text] [PDF]  

SHORT COMMUNICATION:

Thomayant Prueksaritanont, Bennett Ma, Xiaojun Fang, Raju Subramanian, Jian Yu, and Jiunn H. Lin
beta -Oxidation of Simvastatin in Mouse Liver Preparations
Drug Metab Dispos 2001 29: 1251-1255. [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Steve K. Teo, Jill L. Harden, Alison B. Burke, Faruq H. Noormohamed, Mike Youle, Margaret A. Johnson, Barry S. Peters, David I. Stirling, and Steve D. Thomas
Thalidomide Is Distributed into Human Semen after Oral Dosing
Drug Metab Dispos 2001 29: 1355-1357. [Abstract] [Full Text] [PDF]  

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.


Cover Caption:

About the cover: Proposed pathway for the beta -oxidation of SVA. See the article by Prueksaritanont et al. on page 1251 of this issue.



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