Articles:

Alana L. Upthagrove and Wendel L. Nelson

Importance of Amine pK_a and Distribution Coefficient in the Metabolism of Fluorinated Propranolol Derivatives. Preparation, Identification of Metabolite Regioisomers, and Metabolism by CYP2D6
Drug Metab Dispos 2001 29: 1377-1388. [Abstract] [Full Text] [PDF]  

Alana L. Upthagrove and Wendel L. Nelson

Importance of Amine pK_a and Distribution Coefficient in the Metabolism of Fluorinated Propranolol Analogs: Metabolism by CYP1A2
Drug Metab Dispos 2001 29: 1389-1395. [Abstract] [Full Text] [PDF]  

Poh-Gek Forkert and Stephanie M. Boyd

Differential Metabolism of 1,1-Dichloroethylene in Livers of A/J, CD-1, and C57BL/6 Mice
Drug Metab Dispos 2001 29: 1396-1402. [Abstract] [Full Text] [PDF]  

Alexander V. Kuperman, Amit S. Kalgutkar, Anthony Marfat, Robert J. Chambers, and Theodore E. Liston

Pharmacokinetics and Metabolism of a Cysteinyl Leukotriene-1 Receptor Antagonist from the Heterocyclic Chromanol Series in Rats: In Vitro-In Vivo Correlation, Gender-Related Differences, Isoform Identification, and Comparison with Metabolism in Human Hepatic Tissue
Drug Metab Dispos 2001 29: 1403-1409. [Abstract] [Full Text] [PDF]  

Kristopher W. Krausz, Inna Goldfarb, Jeroen T. M. Buters, Tian J. Yang, Frank J. Gonzalez, and Harry V. Gelboin

Monoclonal Antibodies Specific and Inhibitory to Human Cytochromes P450 2C8, 2C9, and 2C19
Drug Metab Dispos 2001 29: 1410-1423. [Abstract] [Full Text] [PDF]  

Donald K. Walker, Kevin N. Dack, Roger P. Dickinson, Katherine S. Fenner, Kim James, David J. Rawson, and Dennis A. Smith

Absorption, Distribution, Metabolism, and Excretion Considerations in Selection of Orally Active Indole-Containing Endothelin Antagonist
Drug Metab Dispos 2001 29: 1424-1431. [Abstract] [Full Text] [PDF]  

Majid Y. Moridani, Hugh Scobie, Akram Jamshidzadeh, Par Salehi, and Peter J. O'Brien

Caffeic Acid, Chlorogenic Acid, and Dihydrocaffeic Acid Metabolism: Glutathione Conjugate Formation
Drug Metab Dispos 2001 29: 1432-1439. [Abstract] [Full Text] [PDF]  

Bruno Combourieu, Lila Elfoul, Anne-Marie Delort, and Sylvie Rabot

Identification of New Derivatives of Sinigrin and Glucotropaeolin Produced by the Human Digestive Microflora Using ¹H NMR Spectroscopy Analysis of in Vitro Incubations
Drug Metab Dispos 2001 29: 1440-1445. [Abstract] [Full Text] [PDF]  

Phyllissa Schmiedlin-Ren, Kenneth E. Thummel, Jeannine M. Fisher, Mary F. Paine, and Paul B. Watkins

Induction of CYP3A4 by 1,25-Dihydroxyvitamin D₃ Is Human Cell Line-Specific and Is Unlikely to Involve Pregnane X Receptor
Drug Metab Dispos 2001 29: 1446-1453. [Abstract] [Full Text] [PDF]  

Elisabeth Hustert, Arne Zibat, Elena Presecan-Siedel, Regina Eiselt, Romy Mueller, Christine Fuß, Ilka Brehm, Ulrich Brinkmann, Michel Eichelbaum, Leszek Wojnowski, and Oliver Burk

Natural Protein Variants of Pregnane X Receptor with Altered Transactivation Activity Toward CYP3A4
Drug Metab Dispos 2001 29: 1454-1459. [Abstract] [Full Text] [PDF]  

Abdul-Kader Souid, Robert C. Fahey, Mehmet K. Aktas, Omer A. Sayin, Sara Karjoo, Gerald L. Newton, Peter D. Sadowitz, Ronald L. Dubowy, and Mark L. Bernstein

Blood Thiols Following Amifostine and Mesna Infusions, a Pediatric Oncology Group Study
Drug Metab Dispos 2001 29: 1460-1466. [Abstract] [Full Text] [PDF]  

Jeff Staudinger, Yaping Liu, Ajay Madan, Sultan Habeebu, and Curtis D. Klaassen

Coordinate Regulation of Xenobiotic and Bile Acid Homeostasis by Pregnane X Receptor
Drug Metab Dispos 2001 29: 1467-1472. [Abstract] [Full Text] [PDF]  

Ping Lu, Yuh Lin, A. David Rodrigues, Thomas H. Rushmore, Thomas A. Baillie, and Magang Shou

Testosterone, 7-Benzyloxyquinoline, and 7-Benzyloxy-4-trifluoromethyl-coumarin Bind to Different Domains within the Active Site of Cytochrome P450 3A4
Drug Metab Dispos 2001 29: 1473-1479. [Abstract] [Full Text] [PDF]  

Mats Hidestrand, Mikael Oscarson, Jarmo S. Salonen, Leena Nyman, Olavi Pelkonen, Miia Turpeinen, and Magnus Ingelman-Sundberg

CYP2B6 and CYP2C19 as the Major Enzymes Responsible for the Metabolism of Selegiline, a Drug Used in the Treatment of Parkinson's Disease, as Revealed from Experiments with Recombinant Enzymes
Drug Metab Dispos 2001 29: 1480-1484. [Abstract] [Full Text] [PDF]  

Tamihide Matsunaga, Hiroyuki Tanaka, Shinsuke Higuchi, Kinya Shibayama, Nobuyuki Kishi, Kazuhito Watanabe, and Ikuo Yamamoto

Oxidation Mechanism of 7-Hydroxy-⁸-tetrahydrocannabinol and 8-Hydroxy-⁹-tetrahydrocannabinol to the Corresponding Ketones by CYP3A11
Drug Metab Dispos 2001 29: 1485-1491. [Abstract] [Full Text] [PDF]  

Stefania D'Angelo, Caterina Manna, Valentina Migliardi, Orazio Mazzoni, Patrizia Morrica, Giovanni Capasso, Gabriele Pontoni, Patrizia Galletti, and Vincenzo Zappia

Pharmacokinetics and Metabolism of Hydroxytyrosol, a Natural Antioxidant from Olive Oil
Drug Metab Dispos 2001 29: 1492-1498. [Abstract] [Full Text] [PDF]  

Wafaa El-Sankary, G. Gordon Gibson, Andy Ayrton, and Nick Plant

Use of a Reporter Gene Assay to Predict and Rank the Potency and Efficacy of CYP3A4 Inducers
Drug Metab Dispos 2001 29: 1499-1504. [Abstract] [Full Text] [PDF]  

Kimie Sai, Naoko Kaniwa, Shogo Ozawa, and Jun-ichi Sawada

A New Metabolite of Irinotecan in Which Formation Is Mediated by Human Hepatic Cytochrome P-450 3a4
Drug Metab Dispos 2001 29: 1505-1513. [Abstract] [Full Text] [PDF]  

Aiming Yu and Robert L. Haining

Comparative Contribution to Dextromethorphan Metabolism by Cytochrome P450 Isoforms in Vitro: Can Dextromethorphan Be Used as a Dual Probe for Both CYP2D6 and CYP3A Activities?
Drug Metab Dispos 2001 29: 1514-1520. [Abstract] [Full Text] [PDF]  

Short Communications:

Xia Wen, Jun-Sheng Wang, Janne T. Backman, Kari T. Kivistö, and Pertti J. Neuvonen

Gemfibrozil Is a Potent Inhibitor of Human Cytochrome P450 2C9
Drug Metab Dispos 2001 29: 1359-1361. [Abstract] [Full Text] [PDF]  

Aiming Yu, Haijun Dong, Dieter Lang, and Robert L. Haining

Characterization of Dextromethorphan O- and N-Demethylation Catalyzed by Highly Purified Recombinant Human CYP2D6
Drug Metab Dispos 2001 29: 1362-1365. [Abstract] [Full Text] [PDF]  

Symposium Report:

Edward T. Morgan, Volker Ullrich, Andreas Daiber, Patrick Schmidt, Naoki Takaya, Hirofumi Shoun, John C. McGiff, Adebayo Oyekan, Craig J. Hanke, William B. Campbell, Chang-Shin Park, Ju-Seop Kang, Hyeon-Gyu Yi, Young-Nam Cha, Daniel Mansuy, and Jean-Luc Boucher

Cytochromes P450 and Flavin MonooxygenasesTargets and Sources of Nitric Oxide
Drug Metab Dispos 2001 29: 1366-1376. [Abstract] [Full Text] [PDF]  

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