Minireview:

Edward T. Morgan

Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?
Drug Metab Dispos 2001 29: 207-212. [Abstract] [Full Text] [PDF]  

Articles:

Päivi Taavitsainen, Risto Juvonen, and Olavi Pelkonen

In Vitro Inhibition of Cytochrome P450 Enzymes in Human Liver Microsomes by a Potent CYP2A6 inhibitor, trans-2-Phenylcyclopropylamine (Tranylcypromine), and Its Nonamine Analog, Cyclopropylbenzene
Drug Metab Dispos 2001 29: 217-222. [Abstract] [Full Text] [PDF]  

Meltem Yilmazer, Jan F. Stevens, Max L. Deinzer, and Donald R. Buhler

In Vitro Biotransformation of Xanthohumol, a Flavonoid from Hops (Humulus lupulus), by Rat Liver Microsomes
Drug Metab Dispos 2001 29: 223-231. [Abstract] [Full Text] [PDF]  

Chun Li, Nathalie Chauret, Laird A. Trimble, Deborah A. Nicoll-Griffith, Jose M. Silva, Dwight MacDonald, Helene Perrier, James A. Yergey, Ted Parton, Rakki P. Alexander, and Graham J. Warrellow

Investigation of the in Vitro Metabolism Profile of a Phosphodiesterase-IV Inhibitor, CDP-840: Leading to Structural Optimization
Drug Metab Dispos 2001 29: 232-241. [Abstract] [Full Text] [PDF]  

Sabine Gerbal-Chaloin, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Martine Daujat, Felix Waechter, Jean-Michel Fabre, Nicolas Carrère, and Patrick Maurel

Induction of CYP2C Genes in Human Hepatocytes in Primary Culture
Drug Metab Dispos 2001 29: 242-251. [Abstract] [Full Text] [PDF]  

Tong Li-Masters and Edward T. Morgan

Effects of Bacterial Lipopolysaccharide on Phenobarbital-Induced CYP2B Expression in Mice
Drug Metab Dispos 2001 29: 252-257. [Abstract] [Full Text] [PDF]  

Poh-Gek Forkert, Raymond P. Lee, and Ken Reid

Involvement of CYP2E1 and Carboxylesterase Enzymes in Vinyl Carbamate Metabolism in Human Lung Microsomes
Drug Metab Dispos 2001 29: 258-263. [Abstract] [Full Text] [PDF]  

Balasubramanian Poonkuzhali, Mammen Chandy, Alok Srivastava, David Dennison, and Rajagopal Krishnamoorthy

Glutathione S-Transferase Activity Influences Busulfan Pharmacokinetics in Patients with Beta Thalassemia Major Undergoing Bone Marrow Transplantation
Drug Metab Dispos 2001 29: 264-267. [Abstract] [Full Text] [PDF]  

Kun-Pin Hsieh, Yen-Yu Lin, Ching-Ling Cheng, Ming-Liang Lai, Min-Shung Lin, Jean-Pascal Siest, and Jin-Ding Huang

Novel Mutations of CYP3A4 in Chinese
Drug Metab Dispos 2001 29: 268-273. [Abstract] [Full Text] [PDF]  

Wataru Honma, Yoshiteru Kamiyama, Kouichi Yoshinari, Hironobu Sasano, Miki Shimada, Kiyoshi Nagata, and Yasushi Yamazoe

Enzymatic Characterization and Interspecies Difference of Phenol Sulfotransferases, ST1A Forms
Drug Metab Dispos 2001 29: 274-281. [Abstract] [Full Text] [PDF]  

Michi Ishigami, Tomoyo Honda, Wataru Takasaki, Toshihiko Ikeda, Toru Komai, Kiyomi Ito, and Yuichi Sugiyama

A Comparison of the Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors on the CYP3A4-Dependent Oxidation of Mexazolam in Vitro
Drug Metab Dispos 2001 29: 282-288. [Abstract] [Full Text] [PDF]  

Jeffrey C. Stevens, Jessica L. Fayer, and Kenneth C. Cassidy

Characterization of 2-[[4-[[2-(1H-Tetrazol-5-ylmethyl)phenyl]methoxy]phenoxy]methyl] Quinoline N-Glucuronidation by in Vitro and in Vivo Approaches
Drug Metab Dispos 2001 29: 289-295. [Abstract] [Full Text] [PDF]  

Samuel M. Poloyac, Alex Perez, Stephen Scheff, and Robert A. Blouin

Tissue-Specific Alterations in the 6-Hydroxylation of Chlorzoxazone Following Traumatic Brain Injury in the Rat
Drug Metab Dispos 2001 29: 296-298. [Abstract] [Full Text] [PDF]  

John W. Holladay, Michael J. Dewey, Bozena B. Michniak, Hugh Wiltshire, Daniel L. Halberg, Paul Weigl, Zhenmin Liang, Kathryn Halifax, W. Edward Lindup, and David J. Back

Elevated Alpha-1-Acid Glycoprotein Reduces the Volume of Distribution and Systemic Clearance of Saquinavir
Drug Metab Dispos 2001 29: 299-303. [Abstract] [Full Text] [PDF]  

Li J. Yu, Jocelyn Matias, Dominic A. Scudiero, Karen M. Hite, Anne Monks, Edward A. Sausville, and David J. Waxman

P450 Enzyme Expression Patterns in the NCI Human Tumor Cell Line Panel
Drug Metab Dispos 2001 29: 304-312. [Abstract] [Full Text] [PDF]  

Bradley K. Wong, Deborah DeFeo-Jones, Raymond E. Jones, Victor M. Garsky, Dong-Mei Feng, Allen Oliff, Masato Chiba, Joan D. Ellis, and Jiunn H. Lin

PSA-Specific and Non-PSA-Specific Conversion of a PSA-Targeted Peptide Conjugate of Doxorubicin to Its Active Metabolites
Drug Metab Dispos 2001 29: 313-318. [Abstract] [Full Text] [PDF]  

Ann C. Nelson, Wei Huang, and David E. Moody

Variables in Human Liver Microsome Preparation: Impact on the Kinetics of L--Acetylmethadol (LAAM) N-Demethylation and Dextromethorphan O-Demethylation
Drug Metab Dispos 2001 29: 319-325. [Abstract] [Full Text] [PDF]  

Zdenek Chmela, Jaroslav Veselý, Karel Lemr, Miroslav Rypka, Jan Hanus, Libor Havlícek, Vladimír Krystof, Lucie Michnová, Kvetoslava Fuksová, and Jirí Lukes

In Vivo Metabolism of 2,6,9-Trisubstituted Purine-Derived Cyclin-Dependent Kinase Inhibitor Bohemine in Mice: Glucosidation as the Principal Metabolic Route
Drug Metab Dispos 2001 29: 326-334. [Abstract] [Full Text] [PDF]  

Eugene Tan and K. Sandy Pang

Sulfation is Rate Limiting in the Futile Cycling Between Estrone and Estrone Sulfate in Enriched Periportal and Perivenous Rat Hepatocytes
Drug Metab Dispos 2001 29: 335-346. [Abstract] [Full Text] [PDF]  

R. Scott Obach, Qing-Yu Zhang, Deborah Dunbar, and Laurence S. Kaminsky

Metabolic Characterization of the Major Human Small Intestinal Cytochrome P450s
Drug Metab Dispos 2001 29: 347-352. [Abstract] [Full Text] [PDF]  

Hyesook Kim, David A. Putt, Richard C. Zangar, C. Roland Wolf, F. Peter Guengerich, Robert J. Edwards, Paul F. Hollenberg, and Raymond F. Novak

Differential Induction of Rat Hepatic Cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in Response to Pyridine Treatment
Drug Metab Dispos 2001 29: 353-360. [Abstract] [Full Text] [PDF]  

Short Communications:

Hye Chin Chung, Sang Hyun Sung, Jin Soo Kim, Young Choong Kim, and Sang Geon Kim

Lack of Cytochrome P450 2E1 (CYP2E1) Induction in the Rat Liver by Starvation without Coprophagy
Drug Metab Dispos 2001 29: 213-216. [Abstract] [Full Text] [PDF]  

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