Articles:

S. Casey Laizure, Timothy Mandrell, Naomi M. Gades, and Robert B. Parker

Cocaethylene Metabolism and Interaction with Cocaine and Ethanol: Role of Carboxylesterases
Drug Metab Dispos 2003 31: 16-20. [Abstract] [Full Text] [PDF]  

Mingxing Xie, Dongfang Yang, Micheal Wu, Bob Xue, and Bingfang Yan

Mouse Liver and Kidney Carboxylesterase (M-LK) Rapidly Hydrolyzes Antitumor Prodrug Irinotecan and the N-Terminal Three Quarter Sequence Determines Substrate Selectivity
Drug Metab Dispos 2003 31: 21-27. [Abstract] [Full Text] [PDF]  

Peter W. Fan, Chungang Gu, Sandra A. Marsh, and Jeffrey C. Stevens

Mechanism-Based Inactivation of Cytochrome P450 2B6 by a Novel Terminal Acetylene Inhibitor
Drug Metab Dispos 2003 31: 28-36. [Abstract] [Full Text] [PDF]  

Cuyue Tang, Jerome H. Hochman, Bennett Ma, Raju Subramanian, and Kamlesh P. Vyas

Acyl Glucuronidation and Glucosidation of a New and Selective Endothelin ET_A Receptor Antagonist in Human Liver Microsomes
Drug Metab Dispos 2003 31: 37-45. [Abstract] [Full Text] [PDF]  

Monica I. Jushchyshyn, Ute M. Kent, and Paul F. Hollenberg

The Mechanism-Based Inactivation of Human Cytochrome P450 2B6 by Phencyclidine
Drug Metab Dispos 2003 31: 46-52. [Abstract] [Full Text] [PDF]  

Thomas A. Clarke and Lucy A. Waskell

The Metabolism of Clopidogrel Is Catalyzed by Human Cytochrome P450 3A and Is Inhibited by Atorvastatin
Drug Metab Dispos 2003 31: 53-59. [Abstract] [Full Text] [PDF]  

Takahito Yamamoto, Naoko Hagima, Masato Nakamura, Yoshiro Kohno, Kiyoshi Nagata, and Yasushi Yamazoe

Differences in Cytochrome P450 Forms Involved in the Metabolism of N,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydrochloride (NE-100), a Novel Sigma Ligand, in Human Liver and Intestine
Drug Metab Dispos 2003 31: 60-66. [Abstract] [Full Text] [PDF]  

Ramaswamy A. Iyer, Bimal Malhotra, Sanaullah Khan, James Mitroka, Samuel Bonacorsi, Jr., Stephen C. Waller, J. Kent Rinehart, and Kishin Kripalani

Comparative Biotransformation of Radiolabeled [¹⁴C]Omapatrilat and Stable-labeled [¹³C₂]Omapatrilat after Oral Administration to Rats, Dogs, and Humans
Drug Metab Dispos 2003 31: 67-75. [Abstract] [Full Text] [PDF]  

Kim Johnson, Ajit Shah, Sarah Jaw-Tsai, James Baxter, and Chandra Prakash

Metabolism, Pharmacokinetics, and Excretion of a Highly Selective N-Methyl-D-aspartate Receptor Antagonist, Traxoprodil, in Human Cytochrome P450 2D6 Extensive and Poor Metabolizers
Drug Metab Dispos 2003 31: 76-87. [Abstract] [Full Text] [PDF]  

Edward L. Mattiuz, G. Douglas Ponsler, Robert J. Barbuch, Paul G. Wood, John H. Mullen, Richard L. Shugert, Qimin Li, William J. Wheeler, Fengjiun Kuo, Preston C. Conrad, and John-Michael Sauer

Disposition and Metabolic Fate of Atomoxetine Hydrochloride: Pharmacokinetics, Metabolism, and Excretion in the Fischer 344 Rat and Beagle Dog
Drug Metab Dispos 2003 31: 88-97. [Abstract] [Full Text] [PDF]  

John-Michael Sauer, G. Douglas Ponsler, Edward L. Mattiuz, Amanda J. Long, Jennifer W. Witcher, Holly R. Thomasson, and Karl A. Desante

Disposition and Metabolic Fate of Atomoxetine Hydrochloride: The Role of CYP2D6 in Human Disposition and Metabolism
Drug Metab Dispos 2003 31: 98-107. [Abstract] [Full Text] [PDF]  

Hideto Jinno, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Mayumi Saeki, Seiichi Ishida, Tetsuji Nishimura, Masanori Ando, Yoshiro Saito, Shogo Ozawa, and Jun-ichi Sawada

Glucuronidation of 7-Ethyl-10-hydroxycamptothecin (SN-38), an Active Metabolite of Irinotecan (CPT-11), by Human UGT1A1 Variants, G71R, P229Q, and Y486D
Drug Metab Dispos 2003 31: 108-113. [Abstract] [Full Text] [PDF]  

V. S. Gopaul, W. Tang, K. Farrell, and F. S. Abbott

Amino Acid Conjugates: Metabolites of 2-Propylpentanoic Acid (Valproic Acid) in Epileptic Patients
Drug Metab Dispos 2003 31: 114-121. [Abstract] [Full Text] [PDF]  

Hao Chen, Weiqi Chen, Liang-Shang Gan, and Abdul E. Mutlib

Metabolism of (S)-5,6-Difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a Non-Nucleoside Reverse Transcriptase Inhibitor, in Human Liver Microsomes. Metabolic Activation and Enzyme Kinetics
Drug Metab Dispos 2003 31: 122-132. [Abstract] [Full Text] [PDF]  

Soundararajan Krishnaswamy, Su X. Duan, Lisa L. von Moltke, David J. Greenblatt, and Michael H. Court

Validation of Serotonin (5-Hydroxtryptamine) as an in Vitro Substrate Probe for Human UDP-Glucuronosyltransferase (UGT) 1A6
Drug Metab Dispos 2003 31: 133-139. [Abstract] [Full Text] [PDF]  

Hiroki Inoue, Go Yuki, Hiroshi Yokota, and Seiyu Kato

Bisphenol A Glucuronidation and Absorption in Rat Intestine
Drug Metab Dispos 2003 31: 140-144. [Abstract] [Full Text] [PDF]  

Short Communications:

Mohamadi A. Sarkar, Vijay Vadlamuri, Shobha Ghosh, and Douglas D. Glover

Expression and Cyclic Variability of CYP3A4 and CYP3A7 Isoforms in Human Endometrium and Cervix During the Menstrual Cycle
Drug Metab Dispos 2003 31: 1-6. [Abstract] [Full Text] [PDF]  

Thomas K. H. Chang, Stelvio M. Bandiera, and Jie Chen

Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels
Drug Metab Dispos 2003 31: 7-10. [Abstract] [Full Text] [PDF]  

Elaine M. Leslie, Roger G. Deeley, and Susan P. C. Cole

Bioflavonoid Stimulation of Glutathione Transport by the 190-kDa Multidrug Resistance Protein 1 (MRP1)
Drug Metab Dispos 2003 31: 11-15. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Bertrand Rochat, Elizabeth M. J. Gillam, and Martin S. Lennard

Evaluation of Recombinant Cytochromes P450 Activity in Metabolic Pathways
Drug Metab Dispos 2003 31: 145-146. [Full Text] [PDF]  

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