Minireviews:

Donald E. Mager, Elzbieta Wyska, and William J. Jusko

Diversity of Mechanism-Based Pharmacodynamic Models
Drug Metab Dispos 2003 31: 510-518. [Abstract] [Full Text] [PDF]  

Editorial:

James R. Halpert

Editorial
Drug Metab Dispos 2003 31: 509. [Full Text] [PDF]  

Articles:

Hideto Jinno, Mayumi Saeki, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Yoshiro Saito, Shogo Ozawa, Masanori Ando, Kuniaki Shirao, Hironobu Minami, Atsushi Ohtsu, Teruhiko Yoshida, Nagahiro Saijo, and Jun-ichi Sawada

Functional Characterization of Wild-type and Variant (T202I and M59I) Human UDP-glucuronosyltransferase 1A10
Drug Metab Dispos 2003 31: 528-532. [Abstract] [Full Text] [PDF]  

Judy L. Raucy

Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products
Drug Metab Dispos 2003 31: 533-539. [Abstract] [Full Text] [PDF]  

R. Hyland, B. C. Jones, and D. A. Smith

Identification of the Cytochrome P450 Enzymes Involved in the N-Oxidation of Voriconazole
Drug Metab Dispos 2003 31: 540-547. [Abstract] [Full Text] [PDF]  

Camille P. Granvil, Ai-Ming Yu, Guillermo Elizondo, Taro E. Akiyama, Connie Cheung, Lionel Feigenbaum, Kristopher W. Krausz, and Frank J. Gonzalez

Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam
Drug Metab Dispos 2003 31: 548-558. [Abstract] [Full Text] [PDF]  

Susan C. N. Buist, Nathan J. Cherrington, and Curtis D. Klaassen

Endocrine Regulation of Rat Organic Anion Transporters
Drug Metab Dispos 2003 31: 559-564. [Abstract] [Full Text] [PDF]  

Caiping Yao, Kent L. Kunze, William F. Trager, Evan D. Kharasch, and René H. Levy

Comparison of In Vitro and In Vivo Inhibition Potencies of Fluvoxamine toward CYP2C19
Drug Metab Dispos 2003 31: 565-571. [Abstract] [Full Text] [PDF]  

Hong Lu, Xiaofeng Meng, and Chung S. Yang

Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by ()-Epigallocatechin Gallate
Drug Metab Dispos 2003 31: 572-579. [Abstract] [Full Text] [PDF]  

Yoichi Naritomi, Shigeyuki Terashita, Akira Kagayama, and Yuichi Sugiyama

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro
Drug Metab Dispos 2003 31: 580-588. [Abstract] [Full Text] [PDF]  

Yuichiro Watanabe, Miki Nakajima, Noriko Ohashi, Toshiyuki Kume, and Tsuyoshi Yokoi

Glucuronidation of Etoposide in Human Liver Microsomes Is Specifically Catalyzed by UDP-Glucuronosyltransferase 1A1
Drug Metab Dispos 2003 31: 589-595. [Abstract] [Full Text] [PDF]  

Amit S. Kalgutkar, Sue Zhou, Odette A. Fahmi, and Timothy J. Taylor

Influence of Lipophilicity on the Interactions of N-Alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and Their Positively Charged N-Alkyl-4-phenylpyridinium Metabolites with Cytochrome P450 2D6
Drug Metab Dispos 2003 31: 596-605. [Abstract] [Full Text] [PDF]  

Jeannine M. Margolis and R. Scott Obach

Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions
Drug Metab Dispos 2003 31: 606-611. [Abstract] [Full Text] [PDF]  

Arun K. Agrawal and Bernard H. Shapiro

Constitutive and Inducible Hepatic Cytochrome P450 Isoforms in Senescent Male and Female Rats and Response to Low-Dose Phenobarbital
Drug Metab Dispos 2003 31: 612-619. [Abstract] [Full Text] [PDF]  

Hongbing Wang, Stephanie R. Faucette, Darryl Gilbert, Summer L. Jolley, Tatsuya Sueyoshi, Masahiko Negishi, and Edward L. LeCluyse

Glucocorticoid Receptor Enhancement of Pregnane X Receptor-Mediated CYP2B6 Regulation in Primary Human Hepatocytes
Drug Metab Dispos 2003 31: 620-630. [Abstract] [Full Text] [PDF]  

Balázs Dalmadi, János Leibinger, Szabolcs Szeberényi, Tímea Borbás, Sándor Farkas, Zsolt Szombathelyi, and Károly Tihanyi

Identification of Metabolic Pathways Involved in the Biotransformation of Tolperisone by Human Microsomal Enzymes
Drug Metab Dispos 2003 31: 631-636. [Abstract] [Full Text] [PDF]  

Smarajit Maiti and Guangping Chen

Tamoxifen Induction of Aryl Sulfotransferase and Hydroxysteroid Sulfotransferase in Male and Female Rat Liver and Intestine
Drug Metab Dispos 2003 31: 637-644. [Abstract] [Full Text] [PDF]  

Bernd Clement and Katrin Lopian

Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug
Drug Metab Dispos 2003 31: 645-651. [Abstract] [Full Text] [PDF]  

Ji Y. Zhang, Jenny Zhan, Chyung S. Cook, Robert M. Ings, and Alan P. Breau

Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism
Drug Metab Dispos 2003 31: 652-658. [Abstract] [Full Text] [PDF]  

Jean-Paul Payan, Isabelle Boudry, Dominique Beydon, Jean-Paul Fabry, Marie-Christine Grandclaude, Elisabeth Ferrari, and Jean-Claude André

Toxicokinetics and Metabolism of N-[¹⁴C]N-Methyl-2-Pyrrolidone in Male Sprague-Dawley Rats: in Vivo and in Vitro Percutaneous Absorption
Drug Metab Dispos 2003 31: 659-669. [Abstract] [Full Text] [PDF]  

David Turgeon, Jean-Sébastien Carrier, Sarah Chouinard, and Alain Bélanger

Glucuronidation Activity of the UGT2B17 Enzyme toward Xenobiotics
Drug Metab Dispos 2003 31: 670-676. [Abstract] [Full Text] [PDF]  

Takeshi Hirota, Ichiro Ieiri, Hiroshi Takane, Hiroyuki Sano, Katsuyuki Kawamoto, Hironao Aono, Akira Yamasaki, Hiromi Takeuchi, Mikio Masada, Eiji Shimizu, Shun Higuchi, and Kenji Otsubo

Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy
Drug Metab Dispos 2003 31: 677-680. [Abstract] [Full Text] [PDF]  

Short Communications:

Jennifer L. Donovan, C. Lindsay DeVane, Kenneth D. Chavin, Robin M. Taylor, and John S. Markowitz

Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers
Drug Metab Dispos 2003 31: 519-522. [Abstract] [Full Text] [PDF]  

Jeff L. Staudinger, Ajay Madan, Kathleen M. Carol, and Andrew Parkinson

Regulation of Drug Transporter Gene Expression by Nuclear Receptors
Drug Metab Dispos 2003 31: 523-527. [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Srikanth C. Nallani, Bryan Goodwin, Jodi M. Maglich, Donna J. Buckley, Arthur R. Buckley, and Pankaj B. Desai

Induction of Cytochrome P450 3A by Paclitaxel in Mice: Pivotal Role of the Nuclear Xenobiotic Receptor, Pregnane X Receptor
Drug Metab Dispos 2003 31: 681-684. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Leah M. Hesse and Michael H. Court

Quantitation of CYP2B6, Constitutive Androstane Receptor, and Pregnane X Receptor mRNA levels
Drug Metab Dispos 2003 31: 685. [Full Text] [PDF]  

Thomas K. H. Chang, Stelvio M. Bandiera, and Jie Chen

Response to Letter to the Editor
Drug Metab Dispos 2003 31: 686. [Full Text] [PDF]  

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