Perspectives:

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, R. Scott Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh, and Steven A. Wrighton

THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE
Drug Metab Dispos 2003 31: 815-832. [Abstract] [Full Text] [PDF]  

Articles:

Donglu Zhang, Marc Ogan, Richard Gedamke, Vikram Roongta, Renke Dai, Mingshe Zhu, J. Kent Rinehart, Lewis Klunk, and James Mitroka

PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS
Drug Metab Dispos 2003 31: 837-845. [Abstract] [Full Text] [PDF]  

Takaho Watanabe, Christophe Morisseau, John W. Newman, and Bruce D. Hammock

IN VITRO METABOLISM OF THE MAMMALIAN SOLUBLE EPOXIDE HYDROLASE INHIBITOR, 1-CYCLOHEXYL-3-DODECYL-UREA
Drug Metab Dispos 2003 31: 846-853. [Abstract] [Full Text] [PDF]  

Virginie Lattard, Jun Zhang, Quyen Tran, Bjarte Furnes, Daniel Schlenk, and John R. Cashman

TWO NEW POLYMORPHISMS OF THE FMO3 GENE IN CAUCASIAN AND AFRICAN-AMERICAN POPULATIONS: COMPARATIVE GENETIC AND FUNCTIONAL STUDIES
Drug Metab Dispos 2003 31: 854-860. [Abstract] [Full Text] [PDF]  

David C. Evans, Desmond O'Connor, Brian G. Lake, Raymond Evers, Christopher Allen, and Richard Hargreaves

ELETRIPTAN METABOLISM BY HUMAN HEPATIC CYP450 ENZYMES AND TRANSPORT BY HUMAN P-GLYCOPROTEIN
Drug Metab Dispos 2003 31: 861-869. [Abstract] [Full Text] [PDF]  

Timothy K. Tippin, Geraldine Hamilton, Linda Moore, Elizabeth J. Beaudet, Summer Jolley, Thomas A. Brodie, Robert C. Andrews, J. David Becherer, Darryl L. McDougald, Michael D. Gaul, Debie J. Hoivik, Kathy Mellon-Kusibab, Jurgen Lehmann, Steven Kliewer, Steven Novick, Ron Laethem, Zhiyang Zhao, and Edward L. LeCluyse

CYP3A INDUCTION BY N-HYDROXYFORMAMIDE TUMOR NECROSIS FACTOR- CONVERTING ENZYME/MATRIX METALLOPROTEINASE INHIBITORS: USE OF A PREGNANE X RECEPTOR ACTIVATION ASSAY AND PRIMARY HEPATOCYTE CULTURE FOR ASSESSING INDUCTION POTENTIAL IN HUMANS
Drug Metab Dispos 2003 31: 870-877. [Abstract] [Full Text] [PDF]  

Michael A. Wynalda, J. Matthew Hutzler, Michael D. Koets, Terry Podoll, and Larry C. Wienkers

IN VITRO METABOLISM OF CLINDAMYCIN IN HUMAN LIVER AND INTESTINAL MICROSOMES
Drug Metab Dispos 2003 31: 878-887. [Abstract] [Full Text] [PDF]  

Jürgen Borlak, Markus Walles, Karsten Levsen, and Thomas Thum

VERAPAMIL: METABOLISM IN CULTURES OF PRIMARY HUMAN CORONARY ARTERIAL ENDOTHELIAL CELLS
Drug Metab Dispos 2003 31: 888-891. [Abstract] [Full Text] [PDF]  

L.-J. Chen, E. H. Lebetkin, and L. T. Burka

COMPARATIVE DISPOSITION OF (R)-(+)-PULEGONE IN B6C3F1 MICE AND F344 RATS
Drug Metab Dispos 2003 31: 892-899. [Abstract] [Full Text] [PDF]  

Anna Mörck, Heldur Hakk, Ulrika Örn, and Eva Klasson Wehler

DECABROMODIPHENYL ETHER IN THE RAT: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Drug Metab Dispos 2003 31: 900-907. [Abstract] [Full Text] [PDF]  

Chuan Chen, Jeff L. Staudinger, and Curtis D. Klaassen

NUCLEAR RECEPTOR, PREGNANE X RECEPTOR, IS REQUIRED FOR INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES IN MOUSE LIVER BY PREGNENOLONE-16-CARBONITRILE
Drug Metab Dispos 2003 31: 908-915. [Abstract] [Full Text] [PDF]  

Douglas Hagrman, Jerry Goodisman, James C. Dabrowiak, and Abdul-Kader Souid

KINETIC STUDY ON THE REACTION OF CISPLATIN WITH METALLOTHIONEIN
Drug Metab Dispos 2003 31: 916-923. [Abstract] [Full Text] [PDF]  

Ming Hu, Kristopher Krausz, Jun Chen, Xia Ge, Jianqi Li, Harry L. Gelboin, and Frank. J. Gonzalez

IDENTIFICATION OF CYP1A2 AS THE MAIN ISOFORM FOR THE PHASE I HYDROXYLATED METABOLISM OF GENISTEIN AND A PRODRUG CONVERTING ENZYME OF METHYLATED ISOFLAVONES
Drug Metab Dispos 2003 31: 924-931. [Abstract] [Full Text] [PDF]  

Damon R. Demady, Ezra R. Lowe, Andrew C. Everett, Scott S. Billecke, Yasuhiko Kamada, Anwar Y. Dunbar, and Yoichi Osawa

METABOLISM-BASED INACTIVATION OF NEURONAL NITRIC-OXIDE SYNTHASE BY COMPONENTS OF CIGARETTE AND CIGARETTE SMOKE
Drug Metab Dispos 2003 31: 932-937. [Abstract] [Full Text] [PDF]  

Kiran C. Patki, Lisa L. von Moltke, and David J. Greenblatt

IN VITRO METABOLISM OF MIDAZOLAM, TRIAZOLAM, NIFEDIPINE, AND TESTOSTERONE BY HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROMES P450: ROLE OF CYP3A4 AND CYP3A5
Drug Metab Dispos 2003 31: 938-944. [Abstract] [Full Text] [PDF]  

Kiyomi Ito, Kanako Ogihara, Shin-ichi Kanamitsu, and Tomoo Itoh

PREDICTION OF THE IN VIVO INTERACTION BETWEEN MIDAZOLAM AND MACROLIDES BASED ON IN VITRO STUDIES USING HUMAN LIVER MICROSOMES
Drug Metab Dispos 2003 31: 945-954. [Abstract] [Full Text] [PDF]  

Richard Weaver, Ken S. Graham, Iain G. Beattie, and Rob J. Riley

CYTOCHROME P450 INHIBITION USING RECOMBINANT PROTEINS AND MASS SPECTROMETRY/MULTIPLE REACTION MONITORING TECHNOLOGY IN A CASSETTE INCUBATION
Drug Metab Dispos 2003 31: 955-966. [Abstract] [Full Text] [PDF]  

Short Communications:

Kaoru Kobayashi, Kikuko Urashima, Noriaki Shimada, and Kan Chiba

SELECTIVITIES OF HUMAN CYTOCHROME P450 INHIBITORS TOWARD RAT P450 ISOFORMS: STUDY WITH cDNA-EXPRESSED SYSTEMS OF THE RAT
Drug Metab Dispos 2003 31: 833-836. [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Charles W. Locuson, II, Jan L. Wahlstrom, Denise A. Rock, Dan A. Rock, and Jeffrey P. Jones

A NEW CLASS OF CYP2C9 INHIBITORS: PROBING 2C9 SPECIFICITY WITH HIGH-AFFINITY BENZBROMARONE DERIVATIVES
Drug Metab Dispos 2003 31: 967-971. [Abstract] [Full Text] [PDF]  

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