Articles:

Mi-Sook Kim, Sui Wang, Zhongzhou Shen, Christopher J. Kochansky, John R. Strauss, Ronald B. Franklin, and Stella H. Vincent

DIFFERENCES IN THE PHARMACOKINETICS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONISTS IN GENETICALLY OBESE ZUCKER AND SPRAGUE-DAWLEY RATS: IMPLICATIONS OF DECREASED GLUCURONIDATION IN OBESE ZUCKER RATS
Drug Metab Dispos 2004 32: 909-914. [Abstract] [Full Text] [PDF]  

Ursula Breyer-Pfaff, Hans-Jörg Martin, Michael Ernst, and Edmund Maser

ENANTIOSELECTIVITY OF CARBONYL REDUCTION OF 4-METHYLNITROSAMINO-1-(3-PYRIDYL)-1-BUTANONE BY TISSUE FRACTIONS FROM HUMAN AND RAT AND BY ENZYMES ISOLATED FROM HUMAN LIVER
Drug Metab Dispos 2004 32: 915-922. [Abstract] [Full Text] [PDF]  

H. Ericsson, B. Hamrén, S. Bergstrand, M. Elebring, L. Fryklund, M. Heijer, and K. P. Öhman

PHARMACOKINETICS AND METABOLISM OF TESAGLITAZAR, A NOVEL DUAL-ACTING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR / AGONIST, AFTER A SINGLE ORAL AND INTRAVENOUS DOSE IN HUMANS
Drug Metab Dispos 2004 32: 923-929. [Abstract] [Full Text] [PDF]  

Jacqueline Ramírez, Federico Innocenti, Erin G. Schuetz, David A. Flockhart, Mary V. Relling, Raymond Santucci, and Mark J. Ratain

CYP2B6, CYP3A4, AND CYP2C19 ARE RESPONSIBLE FOR THE IN VITRO N-DEMETHYLATION OF MEPERIDINE IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2004 32: 930-936. [Abstract] [Full Text] [PDF]  

Yau Yi Lau, Yung-Hsiang Chen, Tong-tong Liu, Cheng Li, Xiaoming Cui, Ronald E. White, and K.-C. Cheng

EVALUATION OF A NOVEL IN VITRO CACO-2 HEPATOCYTE HYBRID SYSTEM FOR PREDICTING IN VIVO ORAL BIOAVAILABILITY
Drug Metab Dispos 2004 32: 937-942. [Abstract] [Full Text] [PDF]  

Amit S. Kalgutkar and Hang T. Nguyen

IDENTIFICATION OF AN N-METHYL-4-PHENYLPYRIDINIUM-LIKE METABOLITE OF THE ANTIDIARRHEAL AGENT LOPERAMIDE IN HUMAN LIVER MICROSOMES: UNDERLYING REASON(S) FOR THE LACK OF NEUROTOXICITY DESPITE THE BIOACTIVATION EVENT
Drug Metab Dispos 2004 32: 943-952. [Abstract] [Full Text] [PDF]  

David L. Roerig, Said H. Audi, and Susan B. Ahlf

KINETIC CHARACTERIZATION OF P-GLYCOPROTEIN-MEDIATED EFFLUX OF RHODAMINE 6G IN THE INTACT RABBIT LUNG
Drug Metab Dispos 2004 32: 953-958. Published online June 9, 2004; 10.1124/dmd.104.000042 [Abstract] [Full Text] [PDF]  

Konomu Saito, Noriaki Sakai, Hyung-Sub Kim, Mayumi Ishizuka, Akio Kazusaka, and Shoichi Fujita

STRAIN DIFFERENCES IN DIAZEPAM METABOLISM AT ITS THREE METABOLIC SITES IN SPRAGUE-DAWLEY, BROWN NORWAY, DARK AGOUTI, AND WISTAR STRAIN RATS
Drug Metab Dispos 2004 32: 959-965. [Abstract] [Full Text] [PDF]  

Palaniappan Kulanthaivel, Robert J. Barbuch, Rita S. Davidson, Ping Yi, Gregory A. Rener, Edward L. Mattiuz, Chad E. Hadden, Lawrence A. Goodwin, and William J. Ehlhardt

SELECTIVE REDUCTION OF N-OXIDES TO AMINES: APPLICATION TO DRUG METABOLISM
Drug Metab Dispos 2004 32: 966-972. [Abstract] [Full Text] [PDF]  

Hannah M. Jones and J. Brian Houston

SUBSTRATE DEPLETION APPROACH FOR DETERMINING IN VITRO METABOLIC CLEARANCE: TIME DEPENDENCIES IN HEPATOCYTE AND MICROSOMAL INCUBATIONS
Drug Metab Dispos 2004 32: 973-982. Published online June 9, 2004; 10.1124/dmd.104.000125 [Abstract] [Full Text] [PDF]  

Dagmar Fischer, Berit Osburg, Holger Petersen, Thomas Kissel, and Ulrich Bickel

EFFECT OF POLY(ETHYLENE IMINE) MOLECULAR WEIGHT AND PEGYLATION ON ORGAN DISTRIBUTION AND PHARMACOKINETICS OF POLYPLEXES WITH OLIGODEOXYNUCLEOTIDES IN MICE
Drug Metab Dispos 2004 32: 983-992. [Abstract] [Full Text] [PDF]  

Xiaoliang Zhuo, Naiyu Zheng, Carolyn A. Felix, and Ian A. Blair

KINETICS AND REGULATION OF CYTOCHROME P450-MEDIATED ETOPOSIDE METABOLISM
Drug Metab Dispos 2004 32: 993-1000. [Abstract] [Full Text] [PDF]  

Nieves Pizarro, Magí Farré, Mitona Pujadas, Ana M^a Peiró, Pere N Roset, Jesús Joglar, and Rafael de la Torre

STEREOCHEMICAL ANALYSIS OF 3,4-METHYLENEDIOXYMETHAMPHETAMINE AND ITS MAIN METABOLITES IN HUMAN SAMPLES INCLUDING THE CATECHOL-TYPE METABOLITE (3,4-DIHYDROXYMETHAMPHETAMINE)
Drug Metab Dispos 2004 32: 1001-1007. [Abstract] [Full Text] [PDF]  

Christopher J. Matheny, Rabia Y. Ali, Xiaodong Yang, and Gary M. Pollack

EFFECT OF PROTOTYPICAL INDUCING AGENTS ON P-GLYCOPROTEIN AND CYP3A EXPRESSION IN MOUSE TISSUES
Drug Metab Dispos 2004 32: 1008-1014. [Abstract] [Full Text] [PDF]  

Bindhu V. Karanam, Cornelis E.C.A. Hop, David Q. Liu, Mike Wallace, Dennis Dean, Hiroya Satoh, Masakatsu Komuro, Katsuya Awano, and Stella H. Vincent

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL) PHENYL]METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR / AGONIST. I. ROLE OF CYTOCHROME P450, METHYLTRANSFERASES, FLAVIN MONOOXYGENASES, AND ESTERASES
Drug Metab Dispos 2004 32: 1015-1022. Published online June 24, 2004; 10.1124/dmd.104.000034 [Abstract] [Full Text] [PDF]  

David Q. Liu, Bindhu V. Karanam, George A. Doss, Rick R. Sidler, Stella H. Vincent, and Cornelis E.C.A. Hop

IN VITRO METABOLISM OF MK-0767 [(±)-5-[(2,4-DIOXOTHIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[[(4-TRIFLUOROMETHYL)-PHENYL] METHYL]BENZAMIDE], A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR / AGONIST. II. IDENTIFICATION OF METABOLITES BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Drug Metab Dispos 2004 32: 1023-1031. Published online June 24, 2004; 10.1124/dmd.104.000059 [Abstract] [Full Text] [PDF]  

Andrea C. Simmonds, Christopher A. Reilly, R. Michael Baldwin, Burhan I. Ghanayem, Diane L. Lanza, Garold S. Yost, Kathy S. Collins, and Poh-Gek Forkert

BIOACTIVATION OF 1,1-DICHLOROETHYLENE TO ITS EPOXIDE BY CYP2E1 AND CYP2F ENZYMES
Drug Metab Dispos 2004 32: 1032-1039. [Abstract] [Full Text] [PDF]  

Yoshinori Nagata, Hiroyuki Kusuhara, Shuichi Hirono, Hitoshi Endou, and Yuichi Sugiyama

CARRIER-MEDIATED UPTAKE OF H₂-RECEPTOR ANTAGONISTS BY THE RAT CHOROID PLEXUS: INVOLVEMENT OF RAT ORGANIC ANION TRANSPORTER 3
Drug Metab Dispos 2004 32: 1040-1047. [Abstract] [Full Text] [PDF]  

Mayumi Saeki, Yoshiro Saito, Hideto Jinno, Toshiko Tanaka-Kagawa, Akiko Ohno, Shogo Ozawa, Kazuyuki Ueno, Shiro Kamakura, Naoyuki Kamatani, Kazuo Komamura, Masafumi Kitakaze, and Jun-ichi Sawada

SINGLE NUCLEOTIDE POLYMORPHISMS AND HAPLOTYPE FREQUENCIES OF UGT2B4 AND UGT2B7 IN A JAPANESE POPULATION
Drug Metab Dispos 2004 32: 1048-1054. [Abstract] [Full Text] [PDF]  

Short Communications:

I-Na Park, Il Je Cho, and Sang Geon Kim

CERAMIDE, AN APOPTOTIC RHEOSTAT, INHIBITS CCAAT/ENHANCER BINDING PROTEIN-ß AND NF-E2-RELATED FACTOR-2 ACTIVATION: THE ROLE IN GLUTATHIONE S-TRANSFERASE A2 GENE REPRESSION
Drug Metab Dispos 2004 32: 893-897. [Abstract] [Full Text] [PDF]  

Naomi Mizuno, Michiko Suzuki, Hiroyuki Kusuhara, Hiroshi Suzuki, Kenji Takeuchi, Takuro Niwa, Johan W. Jonker, and Yuichi Sugiyama

IMPAIRED RENAL EXCRETION OF 6-HYDROXY-5,7-DIMETHYL-2-METHYLAMINO-4-(3-PYRIDYLMETHYL) BENZOTHIAZOLE (E3040) SULFATE IN BREAST CANCER RESISTANCE PROTEIN (BCRP1/ABCG2) KNOCKOUT MICE
Drug Metab Dispos 2004 32: 898-901. [Abstract] [Full Text] [PDF]  

Melanie N. Tallman, Shazia Y. Ali, and Philip C. Smith

ALTERED PHARMACOKINETICS OF OMEPRAZOLE IN CYSTIC FIBROSIS KNOCKOUT MICE RELATIVE TO WILD-TYPE MICE
Drug Metab Dispos 2004 32: 902-905. [Abstract] [Full Text] [PDF]  

Jennifer L. Donovan, Kenneth D. Chavin, C. Lindsay Devane, Robin M. Taylor, Jun-Sheng Wang, Ying Ruan, and John S. Markowitz

GREEN TEA (CAMELLIA SINENSIS) EXTRACT DOES NOT ALTER CYTOCHROME P450 3A4 OR 2D6 ACTIVITY IN HEALTHY VOLUNTEERS
Drug Metab Dispos 2004 32: 906-908. Published online June 9, 2004; 10.1124/dmd.104.000083 [Abstract] [Full Text] [PDF]  

Erratum:

CORRECTION TO "GLUCURONIDATION OF THE OXIDATIVE CYTOCHROME P450-MEDIATED PHENOLIC METABOLITES OF THE ENDOCRINE DISRUPTOR PESTICIDE: METHOXYCHLOR BY HUMAN HEPATIC UDP-GLUCURONOSYL TRANSFERASES"
Drug Metab Dispos 2004 32: 1055. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.