Editor's Note:

James R. Halpert

Drug Metab Dispos 2005 33: 1759. [Full Text] [PDF]  

Articles:

Young-Jin Chun, Sang-Kwang Lee, and Mie Young Kim

MODULATION OF HUMAN CYTOCHROME P450 1B1 EXPRESSION BY 2,4,3',5'-TETRAMETHOXYSTILBENE
Drug Metab Dispos 2005 33: 1771-1776. Published online August 24, 2005; 10.1124/dmd.105.006502 [Abstract] [Full Text] [PDF]  

Jun Chen, Stephen Wang, Xiaobin Jia, Susan Bajimaya, Huimin Lin, Vincent H. Tam, and Ming Hu

DISPOSITION OF FLAVONOIDS VIA RECYCLING: COMPARISON OF INTESTINAL VERSUS HEPATIC DISPOSITION
Drug Metab Dispos 2005 33: 1777-1784. Published online August 24, 2005; 10.1124/dmd.105.003673 [Abstract] [Full Text] [PDF]  

Ken-ichi Fujita, Yuichi Ando, Masaru Narabayashi, Toshimichi Miya, Fumio Nagashima, Wataru Yamamoto, Keiji Kodama, Kazuhiro Araki, Hisashi Endo, and Yasutsuna Sasaki

GEFITINIB (IRESSA) INHIBITS THE CYP3A4-MEDIATED FORMATION OF 7-ETHYL-10-(4-AMINO-1-PIPERIDINO)CARBONYLOXYCAMPTOTHECIN BUT ACTIVATES THAT OF 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO]CARBONYLOXYCAMPTOTHECIN FROM IRINOTECAN
Drug Metab Dispos 2005 33: 1785-1790. Published online August 25, 2005; 10.1124/dmd.105.006205 [Abstract] [Full Text] [PDF]  

Takashi Iwanaga, Daisuke Kobayashi, Masamichi Hirayama, Tomoji Maeda, and Ikumi Tamai

INVOLVEMENT OF URIC ACID TRANSPORTER IN INCREASED RENAL CLEARANCE OF THE XANTHINE OXIDASE INHIBITOR OXYPURINOL INDUCED BY A URICOSURIC AGENT, BENZBROMARONE
Drug Metab Dispos 2005 33: 1791-1795. Published online August 31, 2005; 10.1124/dmd.105.006056 [Abstract] [Full Text] [PDF]  

Cuyue Tang and Bennett Ma

GLYCOSIDATION OF AN ENDOTHELIN ET_A RECEPTOR ANTAGONIST AND DICLOFENAC IN HUMAN LIVER MICROSOMES: AGLYCONE-DEPENDENT UDP-SUGAR SELECTIVITY
Drug Metab Dispos 2005 33: 1796-1802. Published online August 29, 2005; 10.1124/dmd.105.005801 [Abstract] [Full Text] [PDF]  

Igor Girault, Nathalie Rougier, Christophe Chesné, Rosette Lidereau, Philippe Beaune, Ivan Bieche, and Isabelle de Waziers

SIMULTANEOUS MEASUREMENT OF 23 ISOFORMS FROM THE HUMAN CYTOCHROME P450 FAMILIES 1 TO 3 BY QUANTITATIVE REVERSE TRANSCRIPTASE-POLYMERASE CHAIN REACTION
Drug Metab Dispos 2005 33: 1803-1810. Published online August 31, 2005; 10.1124/dmd.105.005173 [Abstract] [Full Text] [PDF]  

Hiroyuki Yamanaka, Miki Nakajima, Tatsuki Fukami, Haruko Sakai, Akiko Nakamura, Miki Katoh, Masataka Takamiya, Yasuhiro Aoki, and Tsuyoshi Yokoi

CYP2A6 AND CYP2B6 ARE INVOLVED IN NORNICOTINE FORMATION FROM NICOTINE IN HUMANS: INTERINDIVIDUAL DIFFERENCES IN THESE CONTRIBUTIONS
Drug Metab Dispos 2005 33: 1811-1818. Published online August 31, 2005; 10.1124/dmd.105.006254 [Abstract] [Full Text] [PDF]  

Robin E. Pearce, Jack P. Uetrecht, and J. Steven Leeder

PATHWAYS OF CARBAMAZEPINE BIOACTIVATION IN VITRO: II. THE ROLE OF HUMAN CYTOCHROME P450 ENZYMES IN THE FORMATION OF 2-HYDROXYIMINOSTILBENE
Drug Metab Dispos 2005 33: 1819-1826. Published online August 31, 2005; 10.1124/dmd.105.004861 [Abstract] [Full Text] [PDF]  

Kristina K. Wolf, Sheryl G. Wood, Jane A. Hunt, Brooke W. Walton-Strong, Kazuto Yasuda, Lubin Lan, Su X. Duan, Qin Hao, Steven A. Wrighton, Elizabeth H. Jeffery, Ronald M. Evans, Juliana G. Szakacs, Lisa L. von Moltke, David J. Greenblatt, Michael H. Court, Erin G. Schuetz, Peter R. Sinclair, and Jacqueline F. Sinclair

ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY
Drug Metab Dispos 2005 33: 1827-1836. Published online September 1, 2005; 10.1124/dmd.105.005256 [Abstract] [Full Text] [PDF]  

Kelly A. Regal, Kent L. Kunze, Raimund M. Peter, and Sidney D. Nelson

OXIDATION OF CAFFEINE BY CYP1A2: ISOTOPE EFFECTS AND METABOLIC SWITCHING
Drug Metab Dispos 2005 33: 1837-1844. Published online August 31, 2005; 10.1124/dmd.105.006031 [Abstract] [Full Text] [PDF]  

Yuichi Murakami, Noriko Kohyama, Yasuna Kobayashi, Masayuki Ohbayashi, Hisakazu Ohtani, Yasufumi Sawada, and Toshinori Yamamoto

FUNCTIONAL CHARACTERIZATION OF HUMAN MONOCARBOXYLATE TRANSPORTER 6 (SLC16A5)
Drug Metab Dispos 2005 33: 1845-1851. Published online September 20, 2005; 10.1124/dmd.105.005264 [Abstract] [Full Text] [PDF]  

David Hallifax, Helen C. Rawden, Nancy Hakooz, and J. Brian Houston

PREDICTION OF METABOLIC CLEARANCE USING CRYOPRESERVED HUMAN HEPATOCYTES: KINETIC CHARACTERISTICS FOR FIVE BENZODIAZEPINES
Drug Metab Dispos 2005 33: 1852-1858. Published online September 20, 2005; 10.1124/dmd.105.005389 [Abstract] [Full Text] [PDF]  

D. Tomalik-Scharte, A. Jetter, M. Kinzig-Schippers, A. Skott, F. Sörgel, T. Klaassen, D. Kasel, S. Harlfinger, O. Doroshyenko, D. Frank, J. Kirchheiner, M. Bräter, K. Richter, T. Gramatté, and U. Fuhr

EFFECT OF PROPIVERINE ON CYTOCHROME P450 ENZYMES: A COCKTAIL INTERACTION STUDY IN HEALTHY VOLUNTEERS
Drug Metab Dispos 2005 33: 1859-1866. Published online September 23, 2005; 10.1124/dmd.105.005272 [Abstract] [Full Text] [PDF]  

Zhengyin Yan, H. Marlon Zhong, Noureddine Maher, Rhoda Torres, Gregory C. Leo, Gary W. Caldwell, and Norman Huebert

BIOACTIVATION OF 4-METHYLPHENOL (p-CRESOL) VIA CYTOCHROME P450-MEDIATED AROMATIC OXIDATION IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2005 33: 1867-1876. Published online September 20, 2005; 10.1124/dmd.105.006387 [Abstract] [Full Text] [PDF]  

Jaya Chilakapati, Kartik Shankar, Midhun C. Korrapati, Ronald A. Hill, and Harihara M. Mehendale

SATURATION TOXICOKINETICS OF THIOACETAMIDE: ROLE IN INITIATION OF LIVER INJURY
Drug Metab Dispos 2005 33: 1877-1885. Published online September 23, 2005; 10.1124/dmd.105.005520 [Abstract] [Full Text] [PDF]  

Janelle Y. Saulter, Joseph R. Kurian, Lauren A. Trepanier, Richard R. Tidwell, Arlene S. Bridges, David W. Boykin, Chad E. Stephens, Mariappan Anbazhagan, and James Edwin Hall

UNUSUAL DEHYDROXYLATION OF ANTIMICROBIAL AMIDOXIME PRODRUGS BY CYTOCHROME b₅ AND NADH CYTOCHROME b₅ REDUCTASE
Drug Metab Dispos 2005 33: 1886-1893. Published online August 30, 2005; 10.1124/dmd.105.005017 [Abstract] [Full Text] [PDF]  

Christopher J. Kochansky, Yuan-Qing Xia, Sui Wang, Brian Cato, Mellissa Creighton, Stella H. Vincent, Ronald B. Franklin, and James R. Reed

SPECIES DIFFERENCES IN THE ELIMINATION OF A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR AGONIST HIGHLIGHTED BY OXIDATIVE METABOLISM OF ITS ACYL GLUCURONIDE
Drug Metab Dispos 2005 33: 1894-1904. Published online September 23, 2005; 10.1124/dmd.105.004010 [Abstract] [Full Text] [PDF]  

Yoshiro Saito, Nobumitsu Hanioka, Keiko Maekawa, Takashi Isobe, Yumi Tsuneto, Ryosuke Nakamura, Akiko Soyama, Shogo Ozawa, Toshiko Tanaka-Kagawa, Hideto Jinno, Shizuo Narimatsu, and Jun-ichi Sawada

FUNCTIONAL ANALYSIS OF THREE CYP1A2 VARIANTS FOUND IN A JAPANESE POPULATION
Drug Metab Dispos 2005 33: 1905-1910. Published online September 20, 2005; 10.1124/dmd.105.005819 [Abstract] [Full Text] [PDF]  

Shen-Feng Ma, Makoto Anraku, Yasunori Iwao, Keishi Yamasaki, Ulrich Kragh-Hansen, Noriyuki Yamaotsu, Shuichi Hirono, Toshihiko Ikeda, and Masaki Otagiri

HYDROLYSIS OF ANGIOTENSIN II RECEPTOR BLOCKER PRODRUG OLMESARTAN MEDOXOMIL BY HUMAN SERUM ALBUMIN AND IDENTIFICATION OF ITS CATALYTIC ACTIVE SITES
Drug Metab Dispos 2005 33: 1911-1919. Published online September 23, 2005; 10.1124/dmd.105.006163 [Abstract] [Full Text] [PDF]  

Short Communications:

Kari E. Dicke, Sara M. Skrlin, and Sharon E. Murphy

NICOTINE AND 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-BUTANONE METABOLISM BY CYTOCHROME P450 2B6
Drug Metab Dispos 2005 33: 1760-1764. Published online September 20, 2005; 10.1124/dmd.105.006718 [Abstract] [Full Text] [PDF]  

Donghui Cui, Gary O. Rankin, and Peter J. Harvison

TRANSAMINATION IN THE METABOLISM OF THE NEPHROTOXICANT N-(3,5-DICHLOROPHENYL)SUCCINIMIDE IN RATS
Drug Metab Dispos 2005 33: 1765-1770. Published online September 20, 2005; 10.1124/dmd.105.006593 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Hai-Zhi Bu, Ping Kang, Alan J. Deese, Ping Zhao, and William F. Pool

HUMAN IN VITRO GLUTATHIONYL AND PROTEIN ADDUCTS OF CARBAMAZEPINE-10,11-EPOXIDE, A STABLE AND PHARMACOLOGICALLY ACTIVE METABOLITE OF CARBAMAZEPINE
Drug Metab Dispos 2005 33: 1920-1924. Published online October 4, 2005; 10.1124/dmd.105.006866 [Abstract] [Full Text] [PDF]  

Errata:

CORRECTIONS TO "HUMAN UDP-GLUCURONOSYLTRANSFERASES: ISOFORM SELECTIVITY AND KINETICS OF 4-METHYLUMBELLIFERONE AND 1-NAPHTHOL GLUCURONIDATION, EFFECTS OF ORGANIC SOLVENTS, AND INHIBITION BY DICLOFENAC AND PROBENECID"
Drug Metab Dispos 2005 33: 1925-1926. [Full Text] [PDF]  

CORRECTION TO "SUPPRESSION OF CYTOCHROME P450 2C11 BY AROMATIC HYDROCARBONS: MECHANISTIC INSIGHTS FROM STUDIES OF THE 5'-FLANKING REGION OF THE CYP2C11 GENE"
Drug Metab Dispos 2005 33: 1927. [Full Text] [PDF]  

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