Articles:

R. Robert Vethanayagam, Honggang Wang, Anshul Gupta, Yi Zhang, Fred Lewis, Jashvant D. Unadkat, and Qingcheng Mao

FUNCTIONAL ANALYSIS OF THE HUMAN VARIANTS OF BREAST CANCER RESISTANCE PROTEIN: I206L, N590Y, AND D620N
Drug Metab Dispos 2005 33: 697-705. Published online March 2, 2005; 10.1124/dmd.105.003657 [Abstract] [Full Text] [PDF]  

Zhengyin Yan, Jian Li, Norman Huebert, Gary W. Caldwell, Yanming Du, and Hua Zhong

DETECTION OF A NOVEL REACTIVE METABOLITE OF DICLOFENAC: EVIDENCE FOR CYP2C9-MEDIATED BIOACTIVATION VIA ARENE OXIDES
Drug Metab Dispos 2005 33: 706-713. Published online March 11, 2005; 10.1124/dmd.104.003095 [Abstract] [Full Text] [PDF]  

Man Ho Choi, Paul L. Skipper, John S. Wishnok, and Steven R. Tannenbaum

CHARACTERIZATION OF TESTOSTERONE 11ß-HYDROXYLATION CATALYZED BY HUMAN LIVER MICROSOMAL CYTOCHROMES P450
Drug Metab Dispos 2005 33: 714-718. Published online March 11, 2005; 10.1124/dmd.104.003327 [Abstract] [Full Text] [PDF]  

Patricia E. Schroeder, Gu-Qi Wang, Frank J. Burczynski, and Brian B. Hasinoff

METABOLISM OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE AND ONE OF ITS METABOLITES BY ISOLATED RAT MYOCYTES, HEPATOCYTES, AND BLOOD
Drug Metab Dispos 2005 33: 719-725. Published online March 11, 2005; 10.1124/dmd.104.003186 [Abstract] [Full Text] [PDF]  

Hiroshi Komura and Masahiro Iwaki

NONLINEAR PHARMACOKINETICS OF PROPAFENONE IN RATS AND HUMANS: APPLICATION OF A SUBSTRATE DEPLETION ASSAY USING HEPATOCYTES FOR ASSESSMENT OF NONLINEARITY
Drug Metab Dispos 2005 33: 726-732. Published online March 2, 2005; 10.1124/dmd.104.002550 [Abstract] [Full Text] [PDF]  

T. M. Baughman, R. A. Graham, K. Wells-Knecht, I. S. Silver, L. O. Tyler, M. Wells-Knecht, and Z. Zhao

METABOLIC ACTIVATION OF PIOGLITAZONE IDENTIFIED FROM RAT AND HUMAN LIVER MICROSOMES AND FRESHLY ISOLATED HEPATOCYTES
Drug Metab Dispos 2005 33: 733-738. Published online March 11, 2005; 10.1124/dmd.104.002683 [Abstract] [Full Text] [PDF]  

Peter L. Bonate, Larry Arthaud, John Stuhler, Phyllis Yerino, Randall J. Press, and James Q. Rose

THE DISTRIBUTION, METABOLISM, AND ELIMINATION OF CLOFARABINE IN RATS
Drug Metab Dispos 2005 33: 739-748. Published online March 2, 2005; 10.1124/dmd.104.002592 [Abstract] [Full Text] [PDF]  

Yingjie Guo, Yifan Zhang, Ying Wang, Xiaoyan Chen, Dayong Si, Dafang Zhong, J. Paul Fawcett, and Hui Zhou

ROLE OF CYP2C9 AND ITS VARIANTS (CYP2C9^*3 AND CYP2C9^*13) IN THE METABOLISM OF LORNOXICAM IN HUMANS
Drug Metab Dispos 2005 33: 749-753. Published online March 11, 2005; 10.1124/dmd.105.003616 [Abstract] [Full Text] [PDF]  

Miki Katoh, Tomohito Matsui, Miki Nakajima, Chise Tateno, Yoshinori Soeno, Toru Horie, Kazuhide Iwasaki, Katsutoshi Yoshizato, and Tsuyoshi Yokoi

IN VIVO INDUCTION OF HUMAN CYTOCHROME P450 ENZYMES EXPRESSED IN CHIMERIC MICE WITH HUMANIZED LIVER
Drug Metab Dispos 2005 33: 754-763. Published online March 15, 2005; 10.1124/dmd.104.002600 [Abstract] [Full Text] [PDF]  

Elke S. Perloff, Su X. Duan, Paul R. Skolnik, David J. Greenblatt, and Lisa L. von Moltke

ATAZANAVIR: EFFECTS ON P-GLYCOPROTEIN TRANSPORT AND CYP3A METABOLISM IN VITRO
Drug Metab Dispos 2005 33: 764-770. Published online March 11, 2005; 10.1124/dmd.104.002931 [Abstract] [Full Text] [PDF]  

Teresa Pekol, J. Scott Daniels, Jason Labutti, Ian Parsons, Darrell Nix, Elizabeth Baronas, Frank Hsieh, Liang-Shang Gan, and Gerald Miwa

HUMAN METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB: IDENTIFICATION OF CIRCULATING METABOLITES
Drug Metab Dispos 2005 33: 771-777. Published online March 11, 2005; 10.1124/dmd.104.002956 [Abstract] [Full Text] [PDF]  

Daisuke Abe, Toshiyuki Sakaki, Tatsuya Kusudo, Atsushi Kittaka, Nozomi Saito, Yoshitomo Suhara, Toshie Fujishima, Hiroaki Takayama, Hiromi Hamamoto, Masaki Kamakura, Miho Ohta, and Kuniyo Inouye

METABOLISM OF 2-PROPOXY-1,25-DIHYDROXYVITAMIN D₃ AND 2-(3-HYDROXYPROPOXY)-1,25-DIHYDROXYVITAMIN D₃ BY HUMAN CYP27A1 AND CYP24A1
Drug Metab Dispos 2005 33: 778-784. Published online March 11, 2005; 10.1124/dmd.104.003038 [Abstract] [Full Text] [PDF]  

Eun Ju Jeong, Yong Liu, Huimin Lin, and Ming Hu

SPECIES- AND DISPOSITION MODEL-DEPENDENT METABOLISM OF RALOXIFENE IN GUT AND LIVER: ROLE OF UGT1A10
Drug Metab Dispos 2005 33: 785-794. Published online March 15, 2005; 10.1124/dmd.104.001883 [Abstract] [Full Text] [PDF]  

Namandjé N. Bumpus, Chitra Sridar, Ute M. Kent, and Paul F. Hollenberg

THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION
Drug Metab Dispos 2005 33: 795-802. Published online March 15, 2005; 10.1124/dmd.105.003749 [Abstract] [Full Text] [PDF]  

Masaya Tachibana, Makoto Tanaka, Yasuhiro Masubuchi, and Toshiharu Horie

ACYL GLUCURONIDATION OF FLUOROQUINOLONE ANTIBIOTICS BY THE UDP-GLUCURONOSYLTRANSFERASE 1A SUBFAMILY IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2005 33: 803-811. Published online March 15, 2005; 10.1124/dmd.104.003178 [Abstract] [Full Text] [PDF]  

Annalise Di Marco, Michelle D'Antoni, Silvia Attaccalite, Pietro Carotenuto, and Ralph Laufer

DETERMINATION OF DRUG GLUCURONIDATION AND UDP-GLUCURONOSYLTRANSFERASE SELECTIVITY USING A 96-WELL RADIOMETRIC ASSAY
Drug Metab Dispos 2005 33: 812-819. Published online March 23, 2005; 10.1124/dmd.105.004333 [Abstract] [Full Text] [PDF]  

Georgy Hartmann, Vessela Vassileva, and Micheline Piquette-Miller

IMPACT OF ENDOTOXIN-INDUCED CHANGES IN P-GLYCOPROTEIN EXPRESSION ON DISPOSITION OF DOXORUBICIN IN MICE
Drug Metab Dispos 2005 33: 820-828. Published online March 18, 2005; 10.1124/dmd.104.002568 [Abstract] [Full Text] [PDF]  

Ragini Vuppugalla and Reza Mehvar

ENZYME-SELECTIVE EFFECTS OF NITRIC OXIDE ON AFFINITY AND MAXIMUM VELOCITY OF VARIOUS RAT CYTOCHROMES P450
Drug Metab Dispos 2005 33: 829-836. Published online March 18, 2005; 10.1124/dmd.105.003848 [Abstract] [Full Text] [PDF]  

Kiyomi Ito, David Hallifax, R. Scott Obach, and J. Brian Houston

IMPACT OF PARALLEL PATHWAYS OF DRUG ELIMINATION AND MULTIPLE CYTOCHROME P450 INVOLVEMENT ON DRUG-DRUG INTERACTIONS: CYP2D6 PARADIGM
Drug Metab Dispos 2005 33: 837-844. Published online March 11, 2005; 10.1124/dmd.105.003715 [Abstract] [Full Text] [PDF]  

Karthik Venkatakrishnan and R. Scott Obach

IN VITRO-IN VIVO EXTRAPOLATION OF CYP2D6 INACTIVATION BY PAROXETINE: PREDICTION OF NONSTATIONARY PHARMACOKINETICS AND DRUG INTERACTION MAGNITUDE
Drug Metab Dispos 2005 33: 845-852. Published online March 23, 2005; 10.1124/dmd.105.004077 [Abstract] [Full Text] [PDF]  

Ping Zhao, Kent L. Kunze, and Caroline A. Lee

EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES
Drug Metab Dispos 2005 33: 853-861. Published online March 2, 2005; 10.1124/dmd.104.002832 [Abstract] [Full Text] [PDF]  

Jana Baranová, Eva Anzenbacherová, Pavel Anzenbacher, and Pavel Soucek

MINIPIG CYTOCHROME P450 2E1: COMPARISON WITH HUMAN ENZYME
Drug Metab Dispos 2005 33: 862-865. Published online March 18, 2005; 10.1124/dmd.104.003392 [Abstract] [Full Text] [PDF]  

Helén Tuvesson, Ingrid Hallin, Robert Persson, Birgitta Sparre, Per Olov Gunnarsson, and Janeric Seidegård

CYTOCHROME P450 3A4 IS THE MAJOR ENZYME RESPONSIBLE FOR THE METABOLISM OF LAQUINIMOD, A NOVEL IMMUNOMODULATOR
Drug Metab Dispos 2005 33: 866-872. Published online March 11, 2005; 10.1124/dmd.104.002238 [Abstract] [Full Text] [PDF]  

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