Articles:

Chong-Sheng Chen, Youssef Jounaidi, and David J. Waxman

ENANTIOSELECTIVE METABOLISM AND CYTOTOXICITY OF R-IFOSFAMIDE AND S-IFOSFAMIDE BY TUMOR CELL-EXPRESSED CYTOCHROMES P450
Drug Metab Dispos 2005 33: 1261-1267. Published online May 26, 2005; 10.1124/dmd.105.004788 [Abstract] [Full Text] [PDF]  

Ke-Hua Wu, Yi-Min Cui, Jin-Feng Guo, Ying Zhou, Suo-Di Zhai, Fu-De Cui, and Wei Lu

POPULATION PHARMACOKINETICS OF CYCLOSPORINE IN CLINICAL RENAL TRANSPLANT PATIENTS
Drug Metab Dispos 2005 33: 1268-1275. Published online June 2, 2005; 10.1124/dmd.105.004358 [Abstract] [Full Text] [PDF]  

Xingguo Cheng, Jonathan Maher, Matthew Z. Dieter, and Curtis D. Klaassen

REGULATION OF MOUSE ORGANIC ANION-TRANSPORTING POLYPEPTIDES (OATPS) IN LIVER BY PROTOTYPICAL MICROSOMAL ENZYME INDUCERS THAT ACTIVATE DISTINCT TRANSCRIPTION FACTOR PATHWAYS
Drug Metab Dispos 2005 33: 1276-1282. Published online May 26, 2005; 10.1124/dmd.105.003988 [Abstract] [Full Text] [PDF]  

Ophelia Q. P. Yin, X. J. Shi, B. Tomlinson, and Moses S. S. Chow

EFFECT OF CYP2D6*10 ALLELE ON THE PHARMACOKINETICS OF LORATADINE IN CHINESE SUBJECTS
Drug Metab Dispos 2005 33: 1283-1287. Published online June 2, 2005; 10.1124/dmd.105.005025 [Abstract] [Full Text] [PDF]  

Huadong Tang and Michael Mayersohn

ACCURACY OF ALLOMETRICALLY PREDICTED PHARMACOKINETIC PARAMETERS IN HUMANS: ROLE OF SPECIES SELECTION
Drug Metab Dispos 2005 33: 1288-1293. Published online May 26, 2005; 10.1124/dmd.105.004127 [Abstract] [Full Text] [PDF]  

Huadong Tang and Michael Mayersohn

A MATHEMATICAL DESCRIPTION OF THE FUNCTIONALITY OF CORRECTION FACTORS USED IN ALLOMETRY FOR PREDICTING HUMAN DRUG CLEARANCE
Drug Metab Dispos 2005 33: 1294-1296. Published online May 26, 2005; 10.1124/dmd.105.004135 [Abstract] [Full Text] [PDF]  

Huadong Tang and Michael Mayersohn

A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING
Drug Metab Dispos 2005 33: 1297-1303. Published online June 15, 2005; 10.1124/dmd.105.004143 [Abstract] [Full Text] [PDF]  

Robert J. Riley, D. F. McGinnity, and R. P. Austin

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES
Drug Metab Dispos 2005 33: 1304-1311. Published online June 2, 2005; 10.1124/dmd.105.004259 [Abstract] [Full Text] [PDF]  

Osamu Ueda, Kazumi Sugihara, Shigeru Ohta, and Shigeyuki Kitamura

INVOLVEMENT OF MOLYBDENUM HYDROXYLASES IN REDUCTIVE METABOLISM OF NITRO POLYCYCLIC AROMATIC HYDROCARBONS IN MAMMALIAN SKIN
Drug Metab Dispos 2005 33: 1312-1318. Published online June 2, 2005; 10.1124/dmd.105.005306 [Abstract] [Full Text] [PDF]  

Claudio Giuliano, Mark Jairaj, Christian M. Zafiu, and Ralph Laufer

DIRECT DETERMINATION OF UNBOUND INTRINSIC DRUG CLEARANCE IN THE MICROSOMAL STABILITY ASSAY
Drug Metab Dispos 2005 33: 1319-1324. Published online June 10, 2005; 10.1124/dmd.105.005033 [Abstract] [Full Text] [PDF]  

Nicoline Treijtel, Hanneke van Helvoort, Arjan Barendregt, Bas J. Blaauboer, and Jan C. H. van Eijkeren

THE USE OF SANDWICH-CULTURED RAT HEPATOCYTES TO DETERMINE THE INTRINSIC CLEARANCE OF COMPOUNDS WITH DIFFERENT EXTRACTION RATIOS: 7-ETHOXYCOUMARIN AND WARFARIN
Drug Metab Dispos 2005 33: 1325-1332. Published online June 10, 2005; 10.1124/dmd.105.004390 [Abstract] [Full Text] [PDF]  

Miki Katoh, Tomohito Matsui, Hirotoshi Okumura, Miki Nakajima, Masuhiro Nishimura, Shinsaku Naito, Chise Tateno, Katsutoshi Yoshizato, and Tsuyoshi Yokoi

EXPRESSION OF HUMAN PHASE II ENZYMES IN CHIMERIC MICE WITH HUMANIZED LIVER
Drug Metab Dispos 2005 33: 1333-1340. Published online June 2, 2005; 10.1124/dmd.105.005157 [Abstract] [Full Text] [PDF]  

James C. Sacco and Margaret O. James

SULFONATION OF ENVIRONMENTAL CHEMICALS AND THEIR METABOLITES IN THE POLAR BEAR (Ursus maritimus)
Drug Metab Dispos 2005 33: 1341-1348. Published online June 10, 2005; 10.1124/dmd.105.004648 [Abstract] [Full Text] [PDF]  

Jonathan N. Bauman, Theunis C. Goosen, Meera Tugnait, Vincent Peterkin, Susan I. Hurst, Lee C. Menning, Mark Milad, Michael H. Court, and J. Andrew Williams

UDP-GLUCURONOSYLTRANSFERASE 2B7 IS THE MAJOR ENZYME RESPONSIBLE FOR GEMCABENE GLUCURONIDATION IN HUMAN LIVER MICROSOMES
Drug Metab Dispos 2005 33: 1349-1354. Published online June 24, 2005; 10.1124/dmd.105.005108 [Abstract] [Full Text] [PDF]  

György Lengyel, Zsuzsa Veres, Pál Szabó, László Vereczkey, and Katalin Jemnitz

CANALICULAR AND SINUSOIDAL DISPOSITION OF BILIRUBIN MONO- AND DIGLUCURONIDES IN SANDWICH-CULTURED HUMAN AND RAT PRIMARY HEPATOCYTES
Drug Metab Dispos 2005 33: 1355-1360. Published online June 10, 2005; 10.1124/dmd.105.004481 [Abstract] [Full Text] [PDF]  

Miyuki Kimura, Hiroshi Yamazaki, Masaki Fujieda, Kazuma Kiyotani, Goro Honda, Junji Saruwatari, Kazuko Nakagawa, Takashi Ishizaki, and Tetsuya Kamataki

CYP2A6 IS A PRINCIPAL ENZYME INVOLVED IN HYDROXYLATION OF 1,7-DIMETHYLXANTHINE, A MAIN CAFFEINE METABOLITE, IN HUMANS
Drug Metab Dispos 2005 33: 1361-1366. Published online June 24, 2005; 10.1124/dmd.105.004796 [Abstract] [Full Text] [PDF]  

Patricia E. Schroeder and Brian B. Hasinoff

METABOLISM OF THE ONE-RING OPEN METABOLITES OF THE CARDIOPROTECTIVE DRUG DEXRAZOXANE TO ITS ACTIVE METAL-CHELATING FORM IN THE RAT
Drug Metab Dispos 2005 33: 1367-1372. Published online June 24, 2005; 10.1124/dmd.105.005546 [Abstract] [Full Text] [PDF]  

Joyce K. James, Masato Nakamura, Atsuro Nakazato, Kanyin E. Zhang, Merryl Cramer, Janice Brunner, Jacquelynn Cook, and Weichao G. Chen

METABOLISM AND DISPOSITION OF A POTENT GROUP II METABOTROPIC GLUTAMATE RECEPTOR AGONIST, IN RATS, DOGS, AND MONKEYS
Drug Metab Dispos 2005 33: 1373-1381. Published online June 24, 2005; 10.1124/dmd.105.004978 [Abstract] [Full Text] [PDF]  

Cengiz Ozalp, Elzbieta Szczesna-Skorupa, and Byron Kemper

BIMOLECULAR FLUORESCENCE COMPLEMENTATION ANALYSIS OF CYTOCHROME P450 2C2, 2E1, AND NADPH-CYTOCHROME P450 REDUCTASE MOLECULAR INTERACTIONS IN LIVING CELLS
Drug Metab Dispos 2005 33: 1382-1390. Published online June 24, 2005; 10.1124/dmd.105.005538 [Abstract] [Full Text] [PDF]  

Yuki Tochigi, Naoko Yamashiki, Satoru Ohgiya, Sawako Ganaha, and Hiroshi Yokota

ISOFORM-SPECIFIC EXPRESSION AND INDUCTION OF UDP-GLUCURONOSYLTRANSFERASE IN IMMUNOACTIVATED PERITONEAL MACROPHAGES OF THE RAT
Drug Metab Dispos 2005 33: 1391-1398. Published online June 24, 2005; 10.1124/dmd.105.004879 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Michail A. Alterman, Boris Kornilayev, Tatyana Duzhak, and Dmitry Yakovlev

QUANTITATIVE ANALYSIS OF CYTOCHROME P450 ISOZYMES BY MEANS OF UNIQUE ISOZYME-SPECIFIC TRYPTIC PEPTIDES: A PROTEOMIC APPROACH
Drug Metab Dispos 2005 33: 1399-1407. Published online June 10, 2005; 10.1124/dmd.105.004812 [Abstract] [Full Text] [PDF]  

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