Minireviews:

Anna L. Blobaum

MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?
Drug Metab Dispos 2006 34: 1-7. [Abstract] [Full Text] [PDF]  

Articles:

Jun Zhang and John R. Cashman

QUANTITATIVE ANALYSIS OF FMO GENE mRNA LEVELS IN HUMAN TISSUES
Drug Metab Dispos 2006 34: 19-26. Published online September 23, 2005; 10.1124/dmd.105.006171 [Abstract] [Full Text] [PDF]  

Oksana Kourylko, Caroline Fradette, Mathieu Arcand, and Patrick du Souich

MODULATION OF CYP1A2 AND CYP3A6 CATALYTIC ACTIVITIES BY SERUM FROM RABBITS WITH A TURPENTINE-INDUCED INFLAMMATORY REACTION AND INTERLEUKIN 6
Drug Metab Dispos 2006 34: 27-35. Published online October 4, 2005; 10.1124/dmd.105.006528 [Abstract] [Full Text] [PDF]  

Xu Guo, Vaishali Dixit, Huiping Liu, Albert L. Shroads, George N. Henderson, Margaret O. James, and Peter W. Stacpoole

INHIBITION AND RECOVERY OF RAT HEPATIC GLUTATHIONE S-TRANSFERASE ZETA AND ALTERATION OF TYROSINE METABOLISM FOLLOWING DICHLOROACETATE EXPOSURE AND WITHDRAWAL
Drug Metab Dispos 2006 34: 36-42. Published online September 30, 2005; 10.1124/dmd.105.003996 [Abstract] [Full Text] [PDF]  

Anooshirvan Shayeganpour, Ayman O. S. El-Kadi, and Dion R. Brocks

DETERMINATION OF THE ENZYME(S) INVOLVED IN THE METABOLISM OF AMIODARONE IN LIVER AND INTESTINE OF RAT: THE CONTRIBUTION OF CYTOCHROME P450 3A ISOFORMS
Drug Metab Dispos 2006 34: 43-50. Published online October 4, 2005; 10.1124/dmd.105.006742 [Abstract] [Full Text] [PDF]  

Corinna E. Rüfer, Hansruedi Glatt, and Sabine E. Kulling

STRUCTURAL ELUCIDATION OF HYDROXYLATED METABOLITES OF THE ISOFLAVAN EQUOL BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY
Drug Metab Dispos 2006 34: 51-60. Published online September 30, 2005; 10.1124/dmd.105.004929 [Abstract] [Full Text] [PDF]  

Anna Franzén, Carina Carlsson, Veronica Hermansson, Matti Lang, and Eva B. Brittebo

CYP2A5-MEDIATED ACTIVATION AND EARLY ULTRASTRUCTURAL CHANGES IN THE OLFACTORY MUCOSA: STUDIES ON 2,6-DICHLOROPHENYL METHYLSULFONE
Drug Metab Dispos 2006 34: 61-68. Published online October 12, 2005; 10.1124/dmd.105.006221 [Abstract] [Full Text] [PDF]  

Bill J. Gurley, Gary W. Barone, D. Keith Williams, Julie Carrier, Philip Breen, C. Ryan Yates, Peng-fei Song, Martha A. Hubbard, Yudong Tong, and Sreekhar Cheboyina

EFFECT OF MILK THISTLE (SILYBUM MARIANUM) AND BLACK COHOSH (CIMICIFUGA RACEMOSA) SUPPLEMENTATION ON DIGOXIN PHARMACOKINETICS IN HUMANS
Drug Metab Dispos 2006 34: 69-74. Published online October 12, 2005; 10.1124/dmd.105.006312 [Abstract] [Full Text] [PDF]  

Caroline Aninat, Amélie Piton, Denise Glaise, Typhen Le Charpentier, Sophie Langouët, Fabrice Morel, Christiane Guguen-Guillouzo, and André Guillouzo

EXPRESSION OF CYTOCHROMES P450, CONJUGATING ENZYMES AND NUCLEAR RECEPTORS IN HUMAN HEPATOMA HepaRG CELLS
Drug Metab Dispos 2006 34: 75-83. Published online October 4, 2005; 10.1124/dmd.105.006759 [Abstract] [Full Text] [PDF]  

F. A. Brightman, D. E. Leahy, G. E. Searle, and S. Thomas

APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN RAT PLASMA
Drug Metab Dispos 2006 34: 84-93. Published online October 12, 2005; 10.1124/dmd.105.004804 [Abstract] [Full Text] [PDF] [Data Supplement]   

F. A. Brightman, D. E. Leahy, G. E. Searle, and S. Thomas

APPLICATION OF A GENERIC PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL TO THE ESTIMATION OF XENOBIOTIC LEVELS IN HUMAN PLASMA
Drug Metab Dispos 2006 34: 94-101. Published online October 12, 2005; 10.1124/dmd.105.004838 [Abstract] [Full Text] [PDF] [Data Supplement]   

Chunze Li, Raju Subramanian, Sean Yu, and Thomayant Prueksaritanont

ACYL-COENZYME A FORMATION OF SIMVASTATIN IN MOUSE LIVER PREPARATIONS
Drug Metab Dispos 2006 34: 102-110. Published online October 26, 2005; 10.1124/dmd.105.006650 [Abstract] [Full Text] [PDF]  

Tore Skotland, Svein Olaf Hustvedt, Inger Oulie, Petter Balke Jacobsen, Grete Arneberg Friisk, Ann Svendsen Langøy, Steinar Uran, Jessie Sandosham, Alan Cuthbertson, and Kim Gunnar Toft

NC100668, A NEW TRACER FOR IMAGING OF VENOUS THROMBOEMBOLISM: DISPOSITION AND METABOLISM IN RATS
Drug Metab Dispos 2006 34: 111-120. Published online October 26, 2005; 10.1124/dmd.105.006239 [Abstract] [Full Text] [PDF]  

R. Scott Obach, Anne E. Reed-Hagen, Suzanne S. Krueger, Beth J. Obach, Thomas N. O'Connell, Kathleen S. Zandi, Sandra Miller, and Jotham W. Coe

METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE 4ß2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO
Drug Metab Dispos 2006 34: 121-130. Published online October 12, 2005; 10.1124/dmd.105.006767 [Abstract] [Full Text] [PDF] [Data Supplement]   

Carrie A. Vyhlidal, Roger Gaedigk, and J. Steven Leeder

NUCLEAR RECEPTOR EXPRESSION IN FETAL AND PEDIATRIC LIVER: CORRELATION WITH CYP3A EXPRESSION
Drug Metab Dispos 2006 34: 131-137. Published online October 21, 2005; 10.1124/dmd.105.005967 [Abstract] [Full Text] [PDF]  

Sihem Aouabdi, Gordon Gibson, and Nick Plant

TRANSCRIPTIONAL REGULATION OF THE PXR GENE: IDENTIFICATION AND CHARACTERIZATION OF A FUNCTIONAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR BINDING SITE WITHIN THE PROXIMAL PROMOTER OF PXR
Drug Metab Dispos 2006 34: 138-144. Published online October 21, 2005; 10.1124/dmd.105.006064 [Abstract] [Full Text] [PDF]  

Qing Chen, George A. Doss, Elaine C. Tung, Wensheng Liu, Yui S. Tang, Matthew P. Braun, Varsha Didolkar, John R. Strauss, Regina W. Wang, Ralph A. Stearns, David C. Evans, Thomas A. Baillie, and Wei Tang

EVIDENCE FOR THE BIOACTIVATION OF ZOMEPIRAC AND TOLMETIN BY AN OXIDATIVE PATHWAY: IDENTIFICATION OF GLUTATHIONE ADDUCTS IN VITRO IN HUMAN LIVER MICROSOMES AND IN VIVO IN RATS
Drug Metab Dispos 2006 34: 145-151. Published online October 26, 2005; 10.1124/dmd.105.004341 [Abstract] [Full Text] [PDF]  

Hesham M. Korashy and Ayman O. S. El-Kadi

TRANSCRIPTIONAL REGULATION OF THE NAD(P)H:QUINONE OXIDOREDUCTASE 1 AND GLUTATHIONE S-TRANSFERASE YA GENES BY MERCURY, LEAD, AND COPPER
Drug Metab Dispos 2006 34: 152-165. Published online October 21, 2005; 10.1124/dmd.105.005397 [Abstract] [Full Text] [PDF]  

Aleksandra Galetin, Howard Burt, Laura Gibbons, and J. Brian Houston

PREDICTION OF TIME-DEPENDENT CYP3A4 DRUG-DRUG INTERACTIONS: IMPACT OF ENZYME DEGRADATION, PARALLEL ELIMINATION PATHWAYS, AND INTESTINAL INHIBITION
Drug Metab Dispos 2006 34: 166-175. Published online October 12, 2005; 10.1124/dmd.105.006874 [Abstract] [Full Text] [PDF]  

Taehyeon M. Cho, Randy L. Rose, and Ernest Hodgson

IN VITRO METABOLISM OF NAPHTHALENE BY HUMAN LIVER MICROSOMAL CYTOCHROME P450 ENZYMES
Drug Metab Dispos 2006 34: 176-183. Published online October 21, 2005; 10.1124/dmd.105.005785 [Abstract] [Full Text] [PDF]  

Tomo Daidoji, Mihoko Ozawa, Hirokazu Sakamoto, Toshiro Sako, Hiroki Inoue, Ryo Kurihara, Shinya Hashimoto, and Hiroshi Yokota

SLOW ELIMINATION OF NONYLPHENOL FROM RAT INTESTINE
Drug Metab Dispos 2006 34: 184-190. Published online October 21, 2005; 10.1124/dmd.105.007229 [Abstract] [Full Text] [PDF]  

Short Communications:

Joshua D. Lambert, Mao-Jung Lee, Lauren Diamond, Jihyeung Ju, Jungil Hong, Mousumi Bose, Harold L. Newmark, and Chung S. Yang

DOSE-DEPENDENT LEVELS OF EPIGALLOCATECHIN-3-GALLATE IN HUMAN COLON CANCER CELLS AND MOUSE PLASMA AND TISSUES
Drug Metab Dispos 2006 34: 8-11. Published online October 4, 2005; 10.1124/dmd.104.003434 [Abstract] [Full Text] [PDF]  

Ryan P. Owen, Leah L. Lagpacan, Travis R. Taylor, Melanie De La Cruz, Conrad C. Huang, Michiko Kawamoto, Susan J. Johns, Doug Stryke, Thomas E. Ferrin, and Kathleen M. Giacomini

FUNCTIONAL CHARACTERIZATION AND HAPLOTYPE ANALYSIS OF POLYMORPHISMS IN THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER, ENT2
Drug Metab Dispos 2006 34: 12-15. Published online October 7, 2005; 10.1124/dmd.105.006270 [Abstract] [Full Text] [PDF]  

Piyush M. Vyas, Sanjoy Roychowdhury, and Craig K. Svensson

ROLE OF HUMAN CYCLOOXYGENASE-2 IN THE BIOACTIVATION OF DAPSONE AND SULFAMETHOXAZOLE
Drug Metab Dispos 2006 34: 16-18. Published online October 7, 2005; 10.1124/dmd.105.006890 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Brian W. Ogilvie, Donglu Zhang, Wenying Li, A. David Rodrigues, Amy E. Gipson, Jeff Holsapple, Paul Toren, and Andrew Parkinson

GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS
Drug Metab Dispos 2006 34: 191-197. Published online November 18, 2005; 10.1124/dmd.105.007633 [Abstract] [Full Text] [PDF]  

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