Articles:

Xiaochao Ma, Yatrik Shah, Connie Cheung, Grace L. Guo, Lionel Feigenbaum, Kristopher W. Krausz, Jeffrey R. Idle, and Frank J. Gonzalez

The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A
Drug Metab Dispos 2007 35: 194-200. Published online November 8, 2006; 10.1124/dmd.106.012831 [Abstract] [Full Text] [PDF]  

Qi Wang and Marilyn E. Morris

Flavonoids Modulate Monocarboxylate Transporter-1-Mediated Transport of -Hydroxybutyrate in Vitro and in Vivo
Drug Metab Dispos 2007 35: 201-208. Published online November 15, 2006; 10.1124/dmd.106.012369 [Abstract] [Full Text] [PDF]  

Junichi Enokizono, Hiroyuki Kusuhara, and Yuichi Sugiyama

Involvement of Breast Cancer Resistance Protein (BCRP/ABCG2) in the Biliary Excretion and Intestinal Efflux of Troglitazone Sulfate, the Major Metabolite of Troglitazone with a Cholestatic Effect
Drug Metab Dispos 2007 35: 209-214. Published online November 8, 2006; 10.1124/dmd.106.012567 [Abstract] [Full Text] [PDF]  

Georgina Meneses-Lorente, Christine Pattison, Claire Guyomard, Christophe Chesné, Robert Heavens, Alan P. Watt, and Bindi Sohal

Utility of Long-Term Cultured Human Hepatocytes as an in Vitro Model for Cytochrome P450 Induction
Drug Metab Dispos 2007 35: 215-220. Published online November 8, 2006; 10.1124/dmd.106.009423 [Abstract] [Full Text] [PDF]  

Jun Lu, Yi-Kai Chan, Gregory D. Gamble, Sally D. Poppitt, Asma A. Othman, and Garth J. S. Cooper

Triethylenetetramine and Metabolites: Levels in Relation to Copper and Zinc Excretion in Urine of Healthy Volunteers and Type 2 Diabetic Patients
Drug Metab Dispos 2007 35: 221-227. Published online November 15, 2006; 10.1124/dmd.106.012922 [Abstract] [Full Text] [PDF]  

Snezana Mirkov, Bernard J. Komoroski, Jacqueline Ramírez, Andrea Yoder Graber, Mark J. Ratain, Stephen C. Strom, and Federico Innocenti

Effects of Green Tea Compounds on Irinotecan Metabolism
Drug Metab Dispos 2007 35: 228-233. Published online November 15, 2006; 10.1124/dmd.106.012047 [Abstract] [Full Text] [PDF]  

Xiaochuan Li, Chen Yu, Youli Lu, Yunlong Gu, Jie Lu, Wei Xu, Lijiang Xuan, and Yiping Wang

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Depside Salts from Salvia miltiorrhiza in Rats
Drug Metab Dispos 2007 35: 234-239. Published online November 28, 2006; 10.1124/dmd.106.013045 [Abstract] [Full Text] [PDF]  

Bill J. Gurley, Ashley Swain, Gary W. Barone, D. Keith Williams, Philip Breen, C. Ryan Yates, Leslie B. Stuart, Martha A. Hubbard, Yudong Tong, and Sreekhar Cheboyina

Effect of Goldenseal (Hydrastis canadensis) and Kava Kava (Piper methysticum) Supplementation on Digoxin Pharmacokinetics in Humans
Drug Metab Dispos 2007 35: 240-245. Published online November 1, 2006; 10.1124/dmd.106.012708 [Abstract] [Full Text] [PDF]  

R. Scott Obach, Robert L. Walsky, and Karthik Venkatakrishnan

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions
Drug Metab Dispos 2007 35: 246-255. Published online November 8, 2006; 10.1124/dmd.106.012633 [Abstract] [Full Text] [PDF] [Data Supplement]   

Atsushi Kawase, You Tsunokuni, and Masahiro Iwaki

Effects of Alterations in CAR on Bilirubin Detoxification in Mouse Collagen-Induced Arthritis
Drug Metab Dispos 2007 35: 256-261. Published online November 15, 2006; 10.1124/dmd.106.011536 [Abstract] [Full Text] [PDF]  

Michael J. Avram, Thomas K. Henthorn, Daniel A. Spyker, Tom C. Krejcie, Peter M. Lloyd, James V. Cassella, and Joshua D. Rabinowitz

Recirculatory Pharmacokinetic Model of the Uptake, Distribution, and Bioavailability of Prochlorperazine Administered as a Thermally Generated Aerosol in a Single Breath to Dogs
Drug Metab Dispos 2007 35: 262-267. Published online November 1, 2006; 10.1124/dmd.106.010652 [Abstract] [Full Text] [PDF]  

Xiaodong Wang and Marilyn E. Morris

Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of ABCG2
Drug Metab Dispos 2007 35: 268-274. Published online November 8, 2006; 10.1124/dmd.106.011684 [Abstract] [Full Text] [PDF]  

Kuresh A. Youdim, Christine A. Tyman, Barry C. Jones, and Ruth Hyland

Induction of Cytochrome P450: Assessment in an Immortalized Human Hepatocyte Cell Line (Fa2N4) Using a Novel Higher Throughput Cocktail Assay
Drug Metab Dispos 2007 35: 275-282. Published online November 15, 2006; 10.1124/dmd.106.012864 [Abstract] [Full Text] [PDF]  

Brian J. Dean, Steve Chang, Maria Victoria Silva Elipe, Yuan-Qing Xia, Matt Braun, Eric Soli, Yuming Zhao, Ronald B. Franklin, and Bindhu Karanam

Metabolism of MK-0524, a Prostaglandin D₂ Receptor 1 Antagonist, in Microsomes and Hepatocytes from Preclinical Species and Humans
Drug Metab Dispos 2007 35: 283-292. Published online November 28, 2006; 10.1124/dmd.106.011551 [Abstract] [Full Text] [PDF]  

Hayley S. Brown, Michael Griffin, and J. Brian Houston

Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance
Drug Metab Dispos 2007 35: 293-301. Published online November 28, 2006; 10.1124/dmd.106.011569 [Abstract] [Full Text] [PDF]  

Masashi Nagata, Muneaki Hidaka, Hiroshi Sekiya, Yohei Kawano, Keishi Yamasaki, Manabu Okumura, and Kazuhiko Arimori

Effects of Pomegranate Juice on Human Cytochrome P450 2C9 and Tolbutamide Pharmacokinetics in Rats
Drug Metab Dispos 2007 35: 302-305. Published online November 28, 2006; 10.1124/dmd.106.011718 [Abstract] [Full Text] [PDF]  

Jérôme Bouligand, Alain Deroussent, Nicolas Simonnard, Paule Opolon, Jackie Morizet, Elisabeth Connault, Estelle Daudigeos, Micheline Re, Angelo Paci, and Gilles Vassal

Induction of Glutathione Synthesis Explains Pharmacodynamics of High-Dose Busulfan in Mice and Highlights Putative Mechanisms of Drug Interaction
Drug Metab Dispos 2007 35: 306-314. Published online November 28, 2006; 10.1124/dmd.106.012880 [Abstract] [Full Text] [PDF]  

Elaine Mutch, Ann K. Daly, and Faith M. Williams

The Relationship between PON1 Phenotype and PON1-192 Genotype in Detoxification of Three Oxons by Human Liver
Drug Metab Dispos 2007 35: 315-320. Published online November 28, 2006; 10.1124/dmd.106.013193 [Abstract] [Full Text] [PDF]  

Short Communications:

Robert S. Foti, Jan L. Wahlstrom, and Larry C. Wienkers

The in Vitro Drug Interaction Potential of Dietary Supplements Containing Multiple Herbal Components
Drug Metab Dispos 2007 35: 185-188. Published online November 8, 2006; 10.1124/dmd.106.012724 [Abstract] [Full Text] [PDF]  

Robert J. Foxenberg, Barbara P. McGarrigle, James B. Knaak, Paul J. Kostyniak, and James R. Olson

Human Hepatic Cytochrome P450-Specific Metabolism of Parathion and Chlorpyrifos
Drug Metab Dispos 2007 35: 189-193. Published online November 1, 2006; 10.1124/dmd.106.012427 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Arik Dahan and Amnon Hoffman

Mode of Administration-Dependent Brain Uptake of Indomethacin: Sustained Systemic Input Increases Brain Influx
Drug Metab Dispos 2007 35: 321-324. Published online December 1, 2006; 10.1124/dmd.106.011817 [Abstract] [Full Text] [PDF]  

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