DMD -- Table of Contents (35 [3])

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March 2007; 35 (3)   [Index by Author] [Cover Caption]

       Articles

       Short Communications

       Letters to the Editor

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Articles:

Nicolas Picard, Nassim Djebli, François-Ludovic Sauvage, and Pierre Marquet: Metabolism of Sirolimus in the Presence or Absence of Cyclosporine by Genotyped Human Liver Microsomes and Recombinant Cytochromes P450 3A4 and 3A5
Drug Metab Dispos 2007 35: 350-355. Published online December 6, 2006; 10.1124/dmd.106.012161 [Abstract] [Full Text] [PDF]

Keisuke Mitsuoka, Yukio Kato, Yoshiyuki Kubo, and Akira Tsuji: Functional Expression of Stereoselective Metabolism of Cephalexin by Exogenous Transfection of Oligopeptide Transporter PEPT1
Drug Metab Dispos 2007 35: 356-362. Published online December 1, 2006; 10.1124/dmd.106.010405 [Abstract] [Full Text] [PDF]

K. Bowalgaha, D. J. Elliot, P. I. Mackenzie, K. M. Knights, and J. O. Miners: The Glucuronidation of ${Delta}$ ⁴-3-Keto C19- and C21-Hydroxysteroids by Human Liver Microsomal and Recombinant UDP-glucuronosyltransferases (UGTs): 6 ${alpha}$ - and 21-Hydroxyprogesterone Are Selective Substrates for UGT2B7
Drug Metab Dispos 2007 35: 363-370. Published online December 6, 2006; 10.1124/dmd.106.013052 [Abstract] [Full Text] [PDF]

Zhiming Wen, Melanie N. Tallman, Shazia Y. Ali, and Philip C. Smith: UDP-Glucuronosyltransferase 1A1 Is the Principal Enzyme Responsible for Etoposide Glucuronidation in Human Liver and Intestinal Microsomes: Structural Characterization of Phenolic and Alcoholic Glucuronides of Etoposide and Estimation of Enzyme Kinetics
Drug Metab Dispos 2007 35: 371-380. Published online December 6, 2006; 10.1124/dmd.106.012732 [Abstract] [Full Text] [PDF]

Charles J. O'Donnell, Ken Grime, Paul Courtney, Dean Slee, and Robert J. Riley: The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting
Drug Metab Dispos 2007 35: 381-385. Published online December 1, 2006; 10.1124/dmd.106.012344 [Abstract] [Full Text] [PDF]

Richard Reisdorph and Ronald Lindahl: Constitutive and 3-Methylcholanthrene-Induced Rat ALDH3A1 Expression Is Mediated by Multiple Xenobiotic Response Elements
Drug Metab Dispos 2007 35: 386-393. Published online December 6, 2006; 10.1124/dmd.106.012393 [Abstract] [Full Text] [PDF]

Tomoji Maeda, Masamichi Hirayama, Daisuke Kobayashi, Keiji Miyazawa, and Ikumi Tamai: Mechanism of the Regulation of Organic Cation/Carnitine Transporter 1 (SLC22A4) by Rheumatoid Arthritis-Associated Transcriptional Factor RUNX1 and Inflammatory Cytokines
Drug Metab Dispos 2007 35: 394-401. Published online December 1, 2006; 10.1124/dmd.106.012112 [Abstract] [Full Text] [PDF]

Andrew J. Lickteig, Angela L. Slitt, Melek C. Arkan, Michael Karin, and Nathan J. Cherrington: Differential Regulation of Hepatic Transporters in the Absence of Tumor Necrosis Factor- ${alpha}$ , Interleukin-1ß, Interleukin-6, and Nuclear Factor- ${kappa}$ B in Two Models of Cholestasis
Drug Metab Dispos 2007 35: 402-409. Published online December 6, 2006; 10.1124/dmd.106.012138 [Abstract] [Full Text] [PDF]

Akihito Ogasawara, Toshiyuki Kume, and Emiko Kazama: Effect of Oral Ketoconazole on Intestinal First-Pass Effect of Midazolam and Fexofenadine in Cynomolgus Monkeys
Drug Metab Dispos 2007 35: 410-418. Published online December 1, 2006; 10.1124/dmd.106.011288 [Abstract] [Full Text] [PDF]

Kathy Senekeo-Effenberger, Shujuan Chen, Erin Brace-Sinnokrak, Jessica A. Bonzo, Mei-Fei Yueh, Upendra Argikar, Jenny Kaeding, Jocelyn Trottier, Rory P. Remmel, Joseph K. Ritter, Olivier Barbier, and Robert H. Tukey: Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor ${alpha}$ Activation
Drug Metab Dispos 2007 35: 419-427. Published online December 6, 2006; 10.1124/dmd.106.013243 [Abstract] [Full Text] [PDF]

Scott S. Auerbach, Joshua G. DeKeyser, Matthew A. Stoner, and Curtis J. Omiecinski: CAR2 Displays Unique Ligand Binding and RXR ${alpha}$ Heterodimerization Characteristics
Drug Metab Dispos 2007 35: 428-439. Published online December 28, 2006; 10.1124/dmd.106.012641 [Abstract] [Full Text] [PDF]

Zhiming Wen, David E. Martin, Peter Bullock, Kuo-Hsiung Lee, and Philip C. Smith: Glucuronidation of Anti-HIV Drug Candidate Bevirimat: Identification of Human UDP-glucuronosyltransferases and Species Differences
Drug Metab Dispos 2007 35: 440-448. Published online December 6, 2006; 10.1124/dmd.106.012815 [Abstract] [Full Text] [PDF]

Stephan T. Stern, Melanie N. Tallman, Kristini K. Miles, Joseph K. Ritter, Robert E. Dupuis, and Philip C. Smith: Gender-Related Differences in Mycophenolate Mofetil-Induced Gastrointestinal Toxicity in Rats
Drug Metab Dispos 2007 35: 449-454. Published online December 15, 2006; 10.1124/dmd.106.012013 [Abstract] [Full Text] [PDF]

J. Cory Kalvass, Emily R. Olson, and Gary M. Pollack: Pharmacokinetics and Pharmacodynamics of Alfentanil in P-Glycoprotein-Competent and P-Glycoprotein-Deficient Mice: P-Glycoprotein Efflux Alters Alfentanil Brain Disposition and Antinociception
Drug Metab Dispos 2007 35: 455-459. Published online December 18, 2006; 10.1124/dmd.106.011445 [Abstract] [Full Text] [PDF]

Rosie Z. Yu, Tae-Won Kim, An Hong, Tanya A. Watanabe, Hans J. Gaus, and Richard S. Geary: Cross-Species Pharmacokinetic Comparison from Mouse to Man of a Second-Generation Antisense Oligonucleotide, ISIS 301012, Targeting Human Apolipoprotein B-100
Drug Metab Dispos 2007 35: 460-468. Published online December 15, 2006; 10.1124/dmd.106.012401 [Abstract] [Full Text] [PDF]

Kazumi Komoriya, Yukio Kato, Yujiro Hayashi, Kazuhiro Ohsuye, Ryuichiro Nishigaki, and Yuichi Sugiyama: Characterization of the Hepatic Disposition of Lanoteplase, a Rationally Designed Variant of Tissue Plasminogen Activator in Rodents
Drug Metab Dispos 2007 35: 469-475. Published online December 18, 2006; 10.1124/dmd.106.012518 [Abstract] [Full Text] [PDF]

Takuro Endo, Masaaki Ban, Kazuma Hirata, Akitoshi Yamamoto, Yoshiki Hara, and Yasunori Momose: Involvement of CYP2A6 in the Formation of a Novel Metabolite, 3-Hydroxypilocarpine, from Pilocarpine in Human Liver Microsomes
Drug Metab Dispos 2007 35: 476-483. Published online December 18, 2006; 10.1124/dmd.106.013425 [Abstract] [Full Text] [PDF]

Nao Torimoto, Itsuko Ishii, Ken-Ichi Toyama, Masayuki Hata, Kanako Tanaka, Hitoshi Shimomura, Hiroyoshi Nakamura, Noritaka Ariyoshi, Shigeru Ohmori, and Mitsukazu Kitada: Helices F–G Are Important for the Substrate Specificities of CYP3A7
Drug Metab Dispos 2007 35: 484-492. Published online December 18, 2006; 10.1124/dmd.106.011304 [Abstract] [Full Text] [PDF]

Sean Ekins, Dayna C. Mankowski, Dennis J. Hoover, Michael P. Lawton, Judith L. Treadway, and H. James Harwood, Jr.: Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Human CYP51 Inhibitors
Drug Metab Dispos 2007 35: 493-500. Published online December 28, 2006; 10.1124/dmd.106.013888 [Abstract] [Full Text] [PDF] [Data Supplement] [Erratum]

Short Communications:

Mark J. Embrechts and Sean Ekins: Classification of Metabolites with Kernel-Partial Least Squares (K-PLS)
Drug Metab Dispos 2007 35: 325-327. Published online December 1, 2006; 10.1124/dmd.106.013185 [Abstract] [Full Text] [PDF]

Makiko Shimizu, Hiroshi Yano, Satomi Nagashima, Norie Murayama, Jun Zhang, John R. Cashman, and Hiroshi Yamazaki: Effect of Genetic Variants of the Human Flavin-Containing Monooxygenase 3 on N- and S-Oxygenation Activities
Drug Metab Dispos 2007 35: 328-330. Published online December 1, 2006; 10.1124/dmd.106.013094 [Abstract] [Full Text] [PDF]

Xin Yan-Fei, Zhou Xiang-Jun, Lu Jie, and Wang Yong-Xiang: Inhibitory Effects of Benzoate on Chiral Inversion and Clearance of N^G-Nitro-Arginine in Conscious Rats
Drug Metab Dispos 2007 35: 331-334. Published online December 15, 2006; 10.1124/dmd.106.011429 [Abstract] [Full Text] [PDF]

Tatsuki Fukami, Miki Nakajima, Haruko Sakai, Miki Katoh, and Tsuyoshi Yokoi: CYP2A13 Metabolizes the Substrates of Human CYP1A2, Phenacetin, and Theophylline
Drug Metab Dispos 2007 35: 335-339. Published online December 18, 2006; 10.1124/dmd.106.011064 [Abstract] [Full Text] [PDF]

Johanna Weiss, Dirk Theile, Nahal Ketabi-Kiyanvash, Heike Lindenmaier, and Walter Emil Haefeli: Inhibition of MRP1/ABCC1, MRP2/ABCC2, and MRP3/ABCC3 by Nucleoside, Nucleotide, and Non-Nucleoside Reverse Transcriptase Inhibitors
Drug Metab Dispos 2007 35: 340-344. Published online December 15, 2006; 10.1124/dmd.106.012765 [Abstract] [Full Text] [PDF]

Giulia Ghibellini, Arlene S. Bridges, Claudia N. Generaux, and Kim L. R. Brouwer: In Vitro and in Vivo Determination of Piperacillin Metabolism in Humans
Drug Metab Dispos 2007 35: 345-349. Published online December 28, 2006; 10.1124/dmd.106.012278 [Abstract] [Full Text] [PDF]

Letters to the Editor:

Jiansong Yang, Masoud Jamei, Karen R. Yeo, Amin Rostami-Hodjegan, and Geoffrey T. Tucker: Misuse of the Well-Stirred Model of Hepatic Drug Clearance
Drug Metab Dispos 2007 35: 501-502. [Full Text] [PDF]

Cover Caption:

About the cover: The human CYP51 pharmacophore for n = 26 inhibitors generated using Catalyst illustrating one hydrophobe (cyan), one hydrogen bond acceptor (green), and two ring aromatic features (orange). See the article by Ekins et al. on page 493 of this issue.