DMD -- Table of Contents (36 [10])

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October 2008; 36 (10)   [Index by Author] [Cover Caption]

       CENTENNIAL PERSPECTIVE

       Articles

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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CENTENNIAL PERSPECTIVE:

Patrick J. Murphy: The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 3, 1984–2008
Drug Metab Dispos 2008 36: 1977-1982. Published online July 17, 2008; 10.1124/dmd.108.023226 [Abstract] [Full Text] [PDF]

Articles:

Anand K. Deo and Stelvio M. Bandiera: Identification of Human Hepatic Cytochrome P450 Enzymes Involved in the Biotransformation of Cholic and Chenodeoxycholic Acid
Drug Metab Dispos 2008 36: 1983-1991. Published online June 26, 2008; 10.1124/dmd.108.022194 [Abstract] [Full Text] [PDF]

Guoying Tai, Leslie J. Dickmann, Nicholas Matovic, James J. DeVoss, Elizabeth M. J. Gillam, and Allan E. Rettie: Re-engineering of CYP2C9 to Probe Acid-Base Substrate Selectivity
Drug Metab Dispos 2008 36: 1992-1997. Published online July 7, 2008; 10.1124/dmd.108.022186 [Abstract] [Full Text] [PDF]

Vadim V. Mozhaev, Lyudmila V. Mozhaeva, Peter C. Michels, and Yuri L. Khmelnitsky: Extractive Biotransformation for Production of Metabolites of Poorly Soluble Compounds: Synthesis of 32-Hydroxy-rifalazil
Drug Metab Dispos 2008 36: 1998-2004. Published online July 7, 2008; 10.1124/dmd.108.021832 [Abstract] [Full Text] [PDF]

Takashi Okura, Asami Hattori, Yusuke Takano, Takenori Sato, Margareta Hammarlund-Udenaes, Tetsuya Terasaki, and Yoshiharu Deguchi: Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone
Drug Metab Dispos 2008 36: 2005-2013. Published online July 7, 2008; 10.1124/dmd.108.022087 [Abstract] [Full Text] [PDF]

Satoshi Kitamura, Kazuya Maeda, Yi Wang, and Yuichi Sugiyama: Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin
Drug Metab Dispos 2008 36: 2014-2023. Published online July 10, 2008; 10.1124/dmd.108.021410 [Abstract] [Full Text] [PDF]

Zaineb A. Fadhel Albayati, Linda P. Dwoskin, and Peter A. Crooks: Pharmacokinetics of the Novel Nicotinic Receptor Antagonist N,N'-Dodecane-1,12-diyl-bis-3-picolinium Dibromide in the Rat
Drug Metab Dispos 2008 36: 2024-2029. Published online July 10, 2008; 10.1124/dmd.108.020354 [Abstract] [Full Text] [PDF]

Nancy M. Jackson and Thomas A. Kocarek: Suppression of CYP2B Induction by Alendronate-Mediated Farnesyl Diphosphate Synthase Inhibition in Primary Cultured Rat Hepatocytes
Drug Metab Dispos 2008 36: 2030-2036. Published online July 10, 2008; 10.1124/dmd.108.022558 [Abstract] [Full Text] [PDF]

Kazuhiko Hanada, Yasutaka Ikemi, Kazutaka Kukita, Kiyoshi Mihara, and Hiroyasu Ogata: Stereoselective First-Pass Metabolism of Verapamil in the Small Intestine and Liver in Rats
Drug Metab Dispos 2008 36: 2037-2042. Published online July 10, 2008; 10.1124/dmd.107.020339 [Abstract] [Full Text] [PDF]

H. Markus Weiss, Ulrike Pfaar, Alain Schweitzer, Hansjörg Wiegand, Andrej Skerjanec, and Horst Schran: Biodistribution and Plasma Protein Binding of Zoledronic Acid
Drug Metab Dispos 2008 36: 2043-2049. Published online July 14, 2008; 10.1124/dmd.108.021071 [Abstract] [Full Text] [PDF]

Wenchang Guo, Philip Reigan, David Siegel, and David Ross: Enzymatic Reduction and Glutathione Conjugation of Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Relevance for Toxicity and Mechanism of Action
Drug Metab Dispos 2008 36: 2050-2057. Published online July 17, 2008; 10.1124/dmd.108.022004 [Abstract] [Full Text] [PDF]

Tsutomu Matsubara, Kouichi Yoshinari, Kazunobu Aoyama, Mika Sugawara, Yuji Sekiya, Kiyoshi Nagata, and Yasushi Yamazoe: Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo
Drug Metab Dispos 2008 36: 2058-2063. Published online July 21, 2008; 10.1124/dmd.108.021501 [Abstract] [Full Text] [PDF]

Chandra Prakash, Weichao Chen, Michelle Rossulek, Kim Johnson, Chenghong Zhang, Thomas O'Connell, Michael Potchoiba, and Deepak Dalvie: Metabolism, Pharmacokinetics, and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and ¹H Nuclear Magnetic Resonance
Drug Metab Dispos 2008 36: 2064-2079. Published online July 24, 2008; 10.1124/dmd.108.022277 [Abstract] [Full Text] [PDF]

Tomohiro Nishimura, Yoshiaki Seki, Kazuko Sato, Takuya Chishu, Noriko Kose, Tetsuya Terasaki, Young-Sook Kang, Yoshimichi Sai, and Emi Nakashima: Enhancement of Zidovudine Uptake by Dehydroepiandrosterone Sulfate in Rat Syncytiotrophoblast Cell Line TR-TBT 18d-1
Drug Metab Dispos 2008 36: 2080-2085. Published online July 24, 2008; 10.1124/dmd.108.021345 [Abstract] [Full Text] [PDF]

Kristina K. Wolf, Kenneth R. Brouwer, Gary M. Pollack, and Kim L. R. Brouwer: Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes
Drug Metab Dispos 2008 36: 2086-2092. Published online July 24, 2008; 10.1124/dmd.108.020842 [Abstract] [Full Text] [PDF]

Chandra Prakash, Weiwei Wang, Thomas O'Connell, and Kim A. Johnson: CYP2C8- and CYP3A-Mediated C-Demethylation of (3-{[(4-tert-Butylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic Acid (CP-533,536), an EP2 Receptor-Selective Prostaglandin E2 Agonist: Characterization of Metabolites by High-Resolution Liquid Chromatography-Tandem Mass Spectrometry and Liquid Chromatography/Mass Spectrometry-Nuclear Magnetic Resonance
Drug Metab Dispos 2008 36: 2093-2103. Published online July 24, 2008; 10.1124/dmd.108.022897 [Abstract] [Full Text] [PDF]

Jian Guo, Ang Liu, Hongmei Cao, Yan Luo, John M. Pezzuto, and Richard B. van Breemen: Biotransformation of the Chemopreventive Agent 2',4',4-Trihydroxychalcone (Isoliquiritigenin) by UDP-Glucuronosyltransferases
Drug Metab Dispos 2008 36: 2104-2112. Published online July 24, 2008; 10.1124/dmd.108.021857 [Abstract] [Full Text] [PDF]

Nina Kassner, Klaus Huse, Hans-Jörg Martin, Ute Gödtel-Armbrust, Annegret Metzger, Ingolf Meineke, Jürgen Brockmöller, Kathrin Klein, Ulrich M. Zanger, Edmund Maser, and Leszek Wojnowski: Carbonyl Reductase 1 Is a Predominant Doxorubicin Reductase in the Human Liver
Drug Metab Dispos 2008 36: 2113-2120. Published online July 17, 2008; 10.1124/dmd.108.022251 [Abstract] [Full Text] [PDF] [Data Supplement]

Mélanie Grondin, Francine Hamel, Fathey Sarhan, and Diana A. Averill-Bates: Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract
Drug Metab Dispos 2008 36: 2121-2129. Published online July 10, 2008; 10.1124/dmd.108.021162 [Abstract] [Full Text] [PDF]

Hua Gao, Lili Yao, Heather W. Mathieu, Ying Zhang, Tristan S. Maurer, Matthew D. Troutman, Dennis O. Scott, Roger B. Ruggeri, and Jing Lin: In Silico Modeling of Nonspecific Binding to Human Liver Microsomes
Drug Metab Dispos 2008 36: 2130-2135. Published online July 7, 2008; 10.1124/dmd.107.020131 [Abstract] [Full Text] [PDF]

Yury Kapelyukh, Mark J. I. Paine, Jean-Didier Maréchal, Michael J. Sutcliffe, C. Roland Wolf, and Gordon C. K. Roberts: Multiple Substrate Binding by Cytochrome P450 3A4: Estimation of the Number of Bound Substrate Molecules
Drug Metab Dispos 2008 36: 2136-2144. Published online July 21, 2008; 10.1124/dmd.108.021733 [Abstract] [Full Text] [PDF] [Data Supplement]

Jayshree Mishra, Qiuye Zhang, Jessica L. Rosson, John Moran, John M. Dopp, and Brien L. Neudeck: Lipopolysaccharide Increases Cell Surface P-glycoprotein That Exhibits Diminished Activity in Intestinal Epithelial Cells
Drug Metab Dispos 2008 36: 2145-2149. Published online August 7, 2008; 10.1124/dmd.108.022632 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Relationship of microsomal unbound fraction with hydrophobicity (a, ACD LogD; b, clogP) (blue +, basic; red ▲, acidic; ○ E, neutral). See article by Gao et al. on page 2130 of this issue.