Articles:

Jian-Dong Duan, Alan M. Jeffrey, and Gary M. Williams

Assessment of the Medicines Lidocaine, Prilocaine, and Their Metabolites, 2,6-Dimethylaniline and 2-Methylaniline, for DNA Adduct Formation in Rat Tissues
Drug Metab Dispos 2008 36: 1470-1475. Published online May 19, 2008; 10.1124/dmd.107.019950 [Abstract] [Full Text] [PDF]  

Nagdeep Giri, Naveed Shaik, Guoyu Pan, Tetsuya Terasaki, Chisato Mukai, Shinji Kitagaki, Naoki Miyakoshi, and William F. Elmquist

Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse
Drug Metab Dispos 2008 36: 1476-1484. Published online April 28, 2008; 10.1124/dmd.108.020974 [Abstract] [Full Text] [PDF]  

Kaori Hosoda, Takashi Furuta, Akitomo Yokokawa, Kenichiro Ogura, Akira Hiratsuka, and Kazuo Ishii

Plasma Profiling of Intact Isoflavone Metabolites by High-Performance Liquid Chromatography and Mass Spectrometric Identification of Flavone Glycosides Daidzin and Genistin in Human Plasma after Administration of Kinako
Drug Metab Dispos 2008 36: 1485-1495. Published online April 28, 2008; 10.1124/dmd.108.021006 [Abstract] [Full Text] [PDF]  

Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui, and Hidetaka Kamimura

Role of Organic Anion Transporters in the Pharmacokinetics of Zonampanel, an -Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist, in Rats
Drug Metab Dispos 2008 36: 1496-1504. Published online April 28, 2008; 10.1124/dmd.107.019828 [Abstract] [Full Text] [PDF]  

Masakatsu Kotsuma, Taro Tokui, Stefan Freudenthaler, and Kenji Nishimura

Effects of Ketoconazole and Quinidine on Pharmacokinetics of Pactimibe and Its Plasma Metabolite, R-125528, in Humans
Drug Metab Dispos 2008 36: 1505-1511. Published online April 30, 2008; 10.1124/dmd.108.021394 [Abstract] [Full Text] [PDF]  

Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas, and Charles W. Locuson

In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition
Drug Metab Dispos 2008 36: 1512-1518. Published online April 30, 2008; 10.1124/dmd.108.021196 [Abstract] [Full Text] [PDF]  

Elin Sjödin, Holger Fritsch, Ulf G. Eriksson, Ulrika Logren, Anders Nordgren, Patrik Forsell, Lars Knutson, and Hans Lennernäs

Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs
Drug Metab Dispos 2008 36: 1519-1528. Published online May 5, 2008; 10.1124/dmd.108.020412 [Abstract] [Full Text] [PDF]  

Sanna Kaivosaari, Päivi Toivonen, Olli Aitio, Julius Sipilä, Mikko Koskinen, Jarmo S. Salonen, and Moshe Finel

Regio- and Stereospecific N-Glucuronidation of Medetomidine: The Differences between UDP Glucuronosyltransferase (UGT) 1A4 and UGT2B10 Account for the Complex Kinetics of Human Liver Microsomes
Drug Metab Dispos 2008 36: 1529-1537. Published online May 12, 2008; 10.1124/dmd.108.021709 [Abstract] [Full Text] [PDF]  

Kristin Lichti-Kaiser and Jeff L. Staudinger

The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes
Drug Metab Dispos 2008 36: 1538-1545. Published online May 12, 2008; 10.1124/dmd.108.021774 [Abstract] [Full Text] [PDF]  

Arthur J. L. Cooper, Islam R. Younis, Zoya V. Niatsetskaya, Boris F. Krasnikov, John T. Pinto, William P. Petros, and Patrick S. Callery

Metabolism of the Cysteine S-Conjugate of Busulfan Involves a β-Lyase Reaction
Drug Metab Dispos 2008 36: 1546-1552. Published online May 12, 2008; 10.1124/dmd.108.020768 [Abstract] [Full Text] [PDF]  

Shingo Sakamoto, Hiroyuki Kusuhara, Kazutoshi Horie, Kohji Takahashi, Takahiko Baba, Jun Ishizaki, and Yuichi Sugiyama

Identification of the Transporters Involved in the Hepatobiliary Transport and Intestinal Efflux of Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) Glucuronide, a Pharmacologically Active Metabolite of S-8921
Drug Metab Dispos 2008 36: 1553-1561. Published online May 12, 2008; 10.1124/dmd.108.020511 [Abstract] [Full Text] [PDF]  

Hui-Xin Liu, Yong Liu, Jiang-Wei Zhang, Wei Li, Hong-Tao Liu, and Ling Yang

UDP-Glucuronosyltransferase 1A6 Is the Major Isozyme Responsible for Protocatechuic Aldehyde Glucuronidation in Human Liver Microsomes
Drug Metab Dispos 2008 36: 1562-1569. Published online May 12, 2008; 10.1124/dmd.108.020560 [Abstract] [Full Text] [PDF]  

L. Harivardhan Reddy, Hania Khoury, Angelo Paci, Alain Deroussent, Humberto Ferreira, Catherine Dubernet, Xavier Declèves, Madeleine Besnard, Helène Chacun, Sinda Lepêtre-Mouelhi, Didier Desmaële, Bernard Rousseau, Christelle Laugier, Jean-Christophe Cintrat, Gilles Vassal, and Patrick Couvreur

Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice
Drug Metab Dispos 2008 36: 1570-1577. Published online May 12, 2008; 10.1124/dmd.108.020735 [Abstract] [Full Text] [PDF]  

Tong Lu, Junling Yang, Xiumei Gao, Ping Chen, Feifei Du, Yan Sun, Fengqing Wang, Fang Xu, Hongcai Shang, Yuhong Huang, Yi Wang, Renzhong Wan, Changxiao Liu, Boli Zhang, and Chuan Li

Plasma and Urinary Tanshinol from Salvia miltiorrhiza (Danshen) Can Be Used as Pharmacokinetic Markers for Cardiotonic Pills, a Cardiovascular Herbal Medicine
Drug Metab Dispos 2008 36: 1578-1586. Published online May 12, 2008; 10.1124/dmd.108.021592 [Abstract] [Full Text] [PDF]  

Jeffrey C. Stevens, Sandra A. Marsh, Matthew J. Zaya, Karen J. Regina, Karthika Divakaran, Min Le, and Ronald N. Hines

Developmental Changes in Human Liver CYP2D6 Expression
Drug Metab Dispos 2008 36: 1587-1593. Published online May 12, 2008; 10.1124/dmd.108.021873 [Abstract] [Full Text] [PDF]  

Laurie P. Volak, Senait Ghirmai, John R. Cashman, and Michael H. Court

Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor
Drug Metab Dispos 2008 36: 1594-1605. Published online May 14, 2008; 10.1124/dmd.108.020552 [Abstract] [Full Text] [PDF]  

Stephan A. Veltkamp, Dick Pluim, Olaf van Tellingen, Jos H. Beijnen, and Jan H. M. Schellens

Extensive Metabolism and Hepatic Accumulation of Gemcitabine After Multiple Oral and Intravenous Administration in Mice
Drug Metab Dispos 2008 36: 1606-1615. Published online May 19, 2008; 10.1124/dmd.108.021048 [Abstract] [Full Text] [PDF]  

Norma Jung, Clara Lehmann, Andrea Rubbert, Meike Knispel, Pia Hartmann, Jan van Lunzen, Hans-Juergen Stellbrink, Gerd Faetkenheuer, and Dirk Taubert

Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection
Drug Metab Dispos 2008 36: 1616-1623. Published online May 19, 2008; 10.1124/dmd.108.020826 [Abstract] [Full Text] [PDF]  

Wei Lu and Jack P. Uetrecht

Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin
Drug Metab Dispos 2008 36: 1624-1636. Published online May 7, 2008; 10.1124/dmd.107.019554 [Abstract] [Full Text] [PDF]  

Robin E. Pearce, Wei Lu, YongQiang Wang, Jack P. Uetrecht, Maria Almira Correia, and J. Steven Leeder

Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine
Drug Metab Dispos 2008 36: 1637-1649. Published online May 7, 2008; 10.1124/dmd.107.019562 [Abstract] [Full Text] [PDF] [Data Supplement]   

William R. Proctor, David L. Bourdet, and Dhiren R. Thakker

Mechanisms Underlying Saturable Intestinal Absorption of Metformin
Drug Metab Dispos 2008 36: 1650-1658. Published online May 5, 2008; 10.1124/dmd.107.020180 [Abstract] [Full Text] [PDF]  

Herve A. Aloysius, Maria V. Silva Elipe, Byron H. Arison, Terry D. Faidley, Bruce F. Michael, Timothy A. Blizzard, Donald R. Thompson, Wesley L. Shoop, and Richard A. Tschirret-Guth

Comparative Disposition and Metabolism of Paraherquamide in Sheep, Gerbils, and Dogs
Drug Metab Dispos 2008 36: 1659-1669. Published online May 27, 2008; 10.1124/dmd.107.019430 [Abstract] [Full Text] [PDF]  

Ken Grime, Peter J. H. Webborn, and Robert J. Riley

Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes
Drug Metab Dispos 2008 36: 1670-1678. Published online May 12, 2008; 10.1124/dmd.108.021055 [Abstract] [Full Text] [PDF]  

Soo Kyung Bae, Shan Cao, Kyung-Ah Seo, Hyunmi Kim, Min-Jung Kim, Ji-Hong Shon, Kwang-Hyeon Liu, Hong-Hao Zhou, and Jae-Gook Shin

Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes
Drug Metab Dispos 2008 36: 1679-1688. Published online May 12, 2008; 10.1124/dmd.108.020727 [Abstract] [Full Text] [PDF] [Data Supplement]   

Kazuto Yasuda, Aarati Ranade, Raman Venkataramanan, Stephen Strom, Jonathan Chupka, Sean Ekins, Erin Schuetz, and Kenneth Bachmann

A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine
Drug Metab Dispos 2008 36: 1689-1697. Published online May 27, 2008; 10.1124/dmd.108.020701 [Abstract] [Full Text] [PDF] [Data Supplement]   

Odette A. Fahmi, Tristan S. Maurer, Mary Kish, Edwin Cardenas, Sherri Boldt, and David Nettleton

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro
Drug Metab Dispos 2008 36: 1698-1708. Published online May 19, 2008; 10.1124/dmd.107.018663 [Abstract] [Full Text] [PDF] [Erratum]   

Banu S. Zolnik, Stephan T. Stern, James M. Kaiser, Yasser Heakal, Jeffrey D. Clogston, Mark Kester, and Scott E. McNeil

Rapid Distribution of Liposomal Short-Chain Ceramide in Vitro and in Vivo
Drug Metab Dispos 2008 36: 1709-1715. Published online May 19, 2008; 10.1124/dmd.107.019679 [Abstract] [Full Text] [PDF]  

Matthew D. Merrell, Jonathan P. Jackson, Lisa M. Augustine, Craig D. Fisher, Angela L. Slitt, Jonathan M. Maher, Wendong Huang, David D. Moore, Youcai Zhang, Curtis D. Klaassen, and Nathan J. Cherrington

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor
Drug Metab Dispos 2008 36: 1716-1721. Published online May 12, 2008; 10.1124/dmd.108.020867 [Abstract] [Full Text] [PDF]  

Cheng Fang, Jun Gu, Fang Xie, Melissa Behr, Weizhu Yang, E. Dale Abel, and Xinxin Ding

Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity
Drug Metab Dispos 2008 36: 1722-1728. Published online May 7, 2008; 10.1124/dmd.108.021881 [Abstract] [Full Text] [PDF]  

Benoît Hosten, Chadi Abbara, Benoît Petit, Angélique Dauvin, Fanchon Bourasset, Robert Farinotti, Patrick Gonin, and Laurence Bonhomme-Faivre

Effect of Interleukin-2 Pretreatment on Paclitaxel Absorption and Tissue Disposition after Oral and Intravenous Administration in Mice
Drug Metab Dispos 2008 36: 1729-1735. Published online May 28, 2008; 10.1124/dmd.107.019091 [Abstract] [Full Text] [PDF]  

Short Communications:

Yi-Jing He, Wei Zhang, Jiang-Hua Tu, Julia Kirchheiner, Yao Chen, Dong Guo, Qing Li, Zhong-Yu Li, Hao Chen, Dong-Li Hu, Dan Wang, and Hong-Hao Zhou

Hepatic Nuclear Factor 1 Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 Substrate Rosuvastatin and Bilirubin
Drug Metab Dispos 2008 36: 1453-1456. Published online April 28, 2008; 10.1124/dmd.108.020503 [Abstract] [Full Text] [PDF]  

Markus Zollinger, Claudia Sayer, Robert Dannecker, Walter Schuler, and Richard Sedrani

The Macrolide Everolimus Forms an Unusual Metabolite in Animals and Humans: Identification of a Phosphocholine Ester
Drug Metab Dispos 2008 36: 1457-1460. Published online April 30, 2008; 10.1124/dmd.108.020651 [Abstract] [Full Text] [PDF]  

Akiko Nakamura, Miki Nakajima, Hiroyuki Yamanaka, Ryoichi Fujiwara, and Tsuyoshi Yokoi

Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines
Drug Metab Dispos 2008 36: 1461-1464. Published online May 14, 2008; 10.1124/dmd.108.021428 [Abstract] [Full Text] [PDF] [Data Supplement]   

Patrick J. Roberts, Kristan D. Rollins, Angela D. M. Kashuba, Mary F. Paine, Andrew C. Nelsen, Eric E. Williams, Cassandra Moran, Jatinder K. Lamba, Erin G. Schuetz, and Roy L. Hawke

The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans
Drug Metab Dispos 2008 36: 1465-1469. Published online May 19, 2008; 10.1124/dmd.107.020065 [Abstract] [Full Text] [PDF]  

Erratum:

CORRECTION TO "IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP2B6 INHIBITORS IN WOOHWANGCHEONGSIMWON SUSPENSION, AN HERBAL PREPARATION USED IN THE TREATMENT AND PREVENTION OF APOPLEXY IN KOREA AND CHINA"
Drug Metab Dispos 2008 36: 1736. [Full Text] [PDF]  

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