24 July 2008

Chandra Prakash, Weiwei wang, Thomas O'Connell, and Kim Johnson

CYP2C8 AND CYP3A MEDIATED C-DEMETHYLATION OF (3-{[4-TERT-BUTYL-BENZYL)-(PYRIDINE-3- SULFONYL)-AMINO]-METHYL}-PHENOXY)ACETIC ACID (CP-533,536), AN EP2 RECEPTOR-SELECTIVE PROSTAGLANDIN E2 AGONIST: CHARACTERIZATION OF METABOLITES BY HIGH RESOLUTION LC-MS/MS AND LC/MS-NMR
Published July 24, 2008; doi: 10.1124/dmd.108.022897 [Abstract] [PDF]  

Chandra Prakash, Chen Weichao, Michelle Rossulek, Kim Johnson, Chenghong Zhang, Thomas O'Connell, Michael Potchoiba, and Deepak Dalvie

Metabolism, Pharmacokinetics and Excretion of a Cholesteryl Ester Transfer Protein Inhibitor, Torcetrapib, in Rats, Monkeys, and Mice: Characterization of Unusual and Novel Metabolites by High Resolution LC-MS/MS and 1H NMR
Published July 24, 2008; doi: 10.1124/dmd.108.022277 [Abstract] [PDF]  

Jian Guo, Ang Liu, Hongmei Cao, Yan Luo, John M. Pezzuto, and Richard B. van Breemen

Biotransformation of the chemopreventive agent isoliquiritigenin by UDP-glucuronosyltransferases
Published July 24, 2008; doi: 10.1124/dmd.108.021857 [Abstract] [PDF]  

Chitra Sridar, Ute M Kent, Kate Noon, Alecia Mc Call, Bill Alworth, Maryam Foroozesh, and Paul F. Hollenberg

Differential Inhibition of P450s 3A4 and 3A5 By the Newly Synthesized Coumarin Derivaties, 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether
Published July 24, 2008; doi: 10.1124/dmd.108.021493 [Abstract] [PDF]  

Tomohiro Nishimura, Yoshiaki Seki, Kazuko Sato, Takuya Chishu, Noriko Kose, Tetsuya Terasaki, Young-sook Kang, Yoshimichi Sai, and Emi Nakashima

Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1
Published July 24, 2008; doi: 10.1124/dmd.108.021345 [Abstract] [PDF]  

Xiaohui Wei, Guowei Dai, Zhongfa Liu, Hao Cheng, Zhiliang Xie, Rebecca Klisovic, Guido Marcucci, and Kenneth K. Chan

Enzyme Kinetics of GTI-2040, a Phosphorothioate Oligonucleotide Targeting Ribonucleotide Reductase
Published July 24, 2008; doi: 10.1124/dmd.108.021295 [Abstract] [PDF]  

Kristina K. Wolf, Kenneth R. Brouwer, Gary M. Pollack, and Kim LR Brouwer

Effect of Albumin on the Biliary Clearance of Compounds in Sandwich-Cultured Rat Hepatocytes
Published July 24, 2008; doi: 10.1124/dmd.108.020842 [Abstract] [PDF]  

21 July 2008

Yury Kapelyukh, Mark J. Paine, Jean-Didier Marechal, Michael J Sutcliffe, C. Roland Wolf, and Gordon Roberts

Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules
Published July 21, 2008; doi: 10.1124/dmd.108.021733 [Abstract] [PDF] [Data Supplement]  

Tsutomu Matsubara, Kouichi Yoshinari, Kazunobu Aoyama, Mika Sugawara, Yuji Sekiya, Kiyoshi Nagata, and Yasushi Yamazoe

Role of vitamin D receptor in the lithocholic acid-mediated CYP3A induction in vitro and in vivo
Published July 21, 2008; doi: 10.1124/dmd.108.021501 [Abstract] [PDF]  

17 July 2008

Patrick Murphy

The development of drug metabolism research as expressed in the publications of ASPET Part 3-1984-2008
Published July 17, 2008; doi: 10.1124/dmd.108.023226 [Abstract] [PDF]  

Nina Kassner, Klaus Huse, Hans-Jorg Martin, Ute Godtel-Armbrust, Annegret Metzger, Ingolf Meineke, Jurgen Brockmoller, Kathrin Klein, Ulrich M Zanger, Edmund Maser, and Leszek Wojnowski

CBR1 is a predominant doxorubicin reductase in the human liver
Published July 17, 2008; doi: 10.1124/dmd.108.022251 [Abstract] [PDF] [Data Supplement]  

Wenchang Guo, Philip Reigan, David Siegel, and David Ross

Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin Hsp90 inhibitors: Relevance for toxicity and mechanism of action
Published July 17, 2008; doi: 10.1124/dmd.108.022004 [Abstract] [PDF]  

14 July 2008

H Markus Weiss, Ulrike Pfaar, Alain Schweitzer, Hansjorg Wiegand, Andrej Skerjanec, and Horst Schran

Biodistribution and plasma protein binding of zoledronic acid
Published July 14, 2008; doi: 10.1124/dmd.108.021071 [Abstract] [PDF]  

10 July 2008

Nancy M. Jackson and Thomas A. Kocarek

Suppression of CYP2B Induction by Alendronate-Mediated Farnesyl Diphosphate Synthase Inhibition in Primary Cultured Rat Hepatocytes
Published July 10, 2008; doi: 10.1124/dmd.108.022558 [Abstract] [PDF]  

Satoshi Kitamura, Kazuya Maeda, Yi Wang, and Yuichi Sugiyama

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin
Published July 10, 2008; doi: 10.1124/dmd.108.021410 [Abstract] [PDF]  

Melanie Grondin, Francine Hamel, Fathey Sarhan, and Diana Averill-Bates

Metabolic activity of cytochrome P450 isoforms in hepatocytes cryopreserved with wheat protein extract
Published July 10, 2008; doi: 10.1124/dmd.108.021162 [Abstract] [PDF]  

Zaineb Fadhel Albayati, Linda P Dwoskin, and Peter Anthony Crooks

Pharmacokinetics of the novel nicotinic receptor antagonist, N,N’-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB)
Published July 10, 2008; doi: 10.1124/dmd.108.020354 [Abstract] [PDF]  

Kazuhiko Hanada, Yasutaka Ikemi, Kazutaka Kukita, Kiyoshi Mihara, and Hiroyasu Ogata

Stereoselective first-pass metabolism of verapamil in the small intestine and liver in rats
Published July 10, 2008; doi: 10.1124/dmd.107.020339 [Abstract] [PDF]  

7 July 2008

Guoying Tai, Leslie Dickmann, Nicholas Matovic, James DeVoss, Elizabeth Gillam, and Allan Rettie

Re-Engineering of CYP2C9 to Probe Acid-Base Substrate Selectivity
Published July 7, 2008; doi: 10.1124/dmd.108.022186 [Abstract] [PDF]  

Takashi Okura, Asami Hattori, Yusuke Takano, Takenori Sato, Margareta Hammarlund-Udenaes, Tetsuya Terasaki, and Yoshiharu Deguchi

Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone
Published July 7, 2008; doi: 10.1124/dmd.108.022087 [Abstract] [PDF]  

Vadim Mozhaev, Lyudmila Mozhaeva, Peter Michels, and Yuri Khmelnitsky

Extractive Biotransformation for Production of Metabolites of Poorly Soluble Compounds. Synthesis of 32-Hydroxy-Rifalazil
Published July 7, 2008; doi: 10.1124/dmd.108.021832 [Abstract] [PDF]  

Hua Gao, Lili Yao, Heather W Mathieu, Ying Zhang, Tristan S Maurer, Matthew D Troutman, Dennis O Scott, Roger B Ruggeri, and Jing Lin

In Silico Modeling of Non-specific Binding to Human Liver Microsomes
Published July 7, 2008; doi: 10.1124/dmd.107.020131 [Abstract] [PDF]  

26 June 2008

Anand K Deo and Stelvio M Bandiera

IDENTIFICATION OF HUMAN HEPATIC CYTOCHROME P450 ENZYMES INVOLVED IN THE BIOTRANSFORMATION OF CHOLIC AND CHENODEOXYCHOLIC ACID
Published June 26, 2008; doi: 10.1124/dmd.108.022194 [Abstract] [PDF]  

23 June 2008

Masashi Mise, Takanori Hashizume, and Setsuko Komuro

Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes
Published June 23, 2008; doi: 10.1124/dmd.108.022301 [Abstract] [PDF]  

SHRINGI SHARMA, Junhai Ou, Stephen C. Strom, Don Mattison, Steve Caritis, and Raman Venkataramanan

Identification of enzymes involved in the metabolism of 17-hydroxyprogesterone Caproate (17-OHPC): An effective agent for prevention of pre-term birth
Published June 23, 2008; doi: 10.1124/dmd.108.021444 [Abstract] [PDF]  

19 June 2008

Deepak Dalvie, Theresa Cosker, Tracey Boyden, Sue Zhou, Clinton M Schroeder, and Michael J Potchoiba

Metabolism Distribution and Excretion of an MMP-13 Inhibitor CP-544439 in Rats and Dogs. Assessment of Metabolic Profile of CP-544439 in Plasma and Urine of Humans
Published June 19, 2008; doi: 10.1124/dmd.108.022566 [Abstract] [PDF]  

Abhinav Nath and William M. Atkins

Principal Component Analysis of CYP2C9 and CYP3A4 Probe Substrate/Inhibitor Panels
Published June 19, 2008; doi: 10.1124/dmd.108.022061 [Abstract] [PDF]  

Marianne Garland, Kirsten M Abildskov, Tung-wah Kiu, Salha S Daniel, Piper Weldy, and Raymond I Stark

Placental transfer and fetal elimination of morphine-3--glucuronide in the pregnant baboon
Published June 19, 2008; doi: 10.1124/dmd.108.021352 [Abstract] [PDF]  

Lauren M. Aleksunes, Yue Cui, and Curtis D. Klaassen

Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared to Placenta
Published June 19, 2008; doi: 10.1124/dmd.108.021337 [Abstract] [PDF]  

Andrew N Gifford, Mel Pilar Espaillat, and Samuel John Gatley

Biodistribution of radiolabeled ethanol in rodents
Published June 19, 2008; doi: 10.1124/dmd.107.020271 [Abstract] [PDF]  

Sarah J Schrieber, Zhiming Wen, Manoli Vourvahis, Philip C. Smith, Michael W. Fried, Angela D.M. Kashuba, and Roy L. Hawke

The Pharmacokinetics of Silymarin is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity
Published June 19, 2008; doi: 10.1124/dmd.107.019604 [Abstract] [PDF]  

16 June 2008

Chellappagounder Thangavel and Bernard H Shapiro

Inherent Sexually Dimorphic Expression of Hepatic CYP2C12 Correlated with Repressed Activation of Growth Hormone-Regulated Signal Transduction in Male Rats
Published June 16, 2008; doi: 10.1124/dmd.108.021451 [Abstract] [PDF]  

Sabrina Ehnert, Andreas K Nussler, Antje Lehmann, and Steven Dooley

Blood monocyte derived Neo-Hepatocytes as in vitro test system for drug-metabolism
Published June 16, 2008; doi: 10.1124/dmd.108.020453 [Abstract] [PDF]  

12 June 2008

lifei Wang, Lisa J Christopher, Donghui Cui, Wenying Li, Ramaswamy Iyer, W Griffith Humphreys, and Donglu Zhang

IDENTIFICATION OF THE HUMAN ENZYMES INVOLVED IN THE OXIDATIVE METABOLISM OF DASATINIB. AN EFFECTIVE APPROACH FOR DETERMINING METABOLITE FORMATION KINETICS
Published June 12, 2008; doi: 10.1124/dmd.107.020255 [Abstract] [PDF]  

Elisabeth A Minthorn, Thomas Mencken, Andrew G King, Art Y Shu, David H Rominger, Richard R Gontarek, Chao Han, Ramesh B Bambal, and Charles B Davis

PHARMACOKINETICS AND BRAIN PENETRATION OF CASOPITANT, A POTENT AND SELECTIVE NK-1 RECEPTOR ANTAGONIST, IN THE FERRET
Published June 12, 2008; doi: 10.1124/dmd.108.021758 [Abstract] [PDF]  

Neslihan Aygun Kocabas, Pinar Aksoy, Linda L. Pelleymounter, Irene Moon, Jeong-Seon Ryu, Judith A. Gilbert, Oreste Ezequel Salavaggione, Bruce W. Eckloff, Eric D. Wieben, Vivien Yee, Richard M. Weinshilboum, and Matthew M. Ames

Gemcitabine Pharmacogenomics: Deoxycytidine Kinase (DCK) and Cytidylate Kinase (CMPK) Gene Resequencing and Functional Genomics
Published June 12, 2008; doi: 10.1124/dmd.108.020925 [Abstract] [PDF] [Data Supplement]  

Shuso Takeda, Koichiro Misawa, Ikuo Yamamoto, and Kazuhito Watanabe

Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis
Published June 12, 2008; doi: 10.1124/dmd.108.020909 [Abstract] [PDF]  

Cuiping Chen, Jeffery L Stock, Xingrong Liu, Jilin Shi, Jeffrey W Van Deusen, Debra A DiMattia, Robert G Dullea, and Sonia M.D. Morais

UTILITY OF THE OATP1B2 KNOCKOUT MOUSE MODEL FOR EVALUATING THE ROLE OF OATP1B2 IN THE HEPATIC UPTAKE OF MODEL COMPOUNDS
Published June 12, 2008; doi: 10.1124/dmd.108.020594 [Abstract] [PDF]  

9 June 2008

Katarina Stark, Zhong-Liu Wu, Cheryl J. Bartleson, and F. Peter Guengerich

mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1
Published June 9, 2008; doi: 10.1124/dmd.108.022020 [Abstract] [PDF] [Data Supplement]  

Mark P. Grillo, Ji Ma, Yohannes Teffera, and Daniel J. Waldon

A Novel Bioactivation Pathway for Diclofenac Initiated by P450 Mediated Oxidative Decarboxylation
Published June 9, 2008; doi: 10.1124/dmd.108.021287 [Abstract] [PDF]  

Anwar Anwar-Mohamed and Ayman O.S. El-Kadi

Down-regulation of the carcinogen metabolizing enzyme cytochrome P450 1a1 by vanadium
Published June 9, 2008; doi: 10.1124/dmd.108.021154 [Abstract] [PDF]  

4 June 2008

Markus Weiss, Marcel Fresneau, Thomas Monius, Anton Stutz, and Andreas Billich

Binding of pimecrolimus and tacrolimus to skin and plasma proteins: Implications for systemic exposure after topical application
Published June 4, 2008; doi: 10.1124/dmd.108.021915 [Abstract] [PDF]  

Rana M. Sawaya and David S. Riddick

Cytochrome P450 2C11 5'-flanking region and promoter mediate in vivo suppression by 3-methylcholanthrene
Published June 4, 2008; doi: 10.1124/dmd.108.020966 [Abstract] [PDF]  

Masakatsu Kotsuma, Hiroyuki Hanzawa, Yoriko Iwata, Kenji Takahashi, and Taro Tokui

Novel Binding Mode of the Acidic CYP2D6 Substrates Pactimibe and its Metabolite, R-125528
Published June 4, 2008; doi: 10.1124/dmd.108.020776 [Abstract] [PDF]  

2 June 2008

Odette A. Fahmi, Sherri Boldt, Mary Kish, R. Scott Obach, and Larry Tremaine

PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA: APPLICATION OF THE RELATIVE INDUCTION SCORE APPROACH USING CRYOPRESERVED HUMAN HEPATOCYTES
Published June 2, 2008; doi: 10.1124/dmd.108.021907 [Abstract] [PDF]  

30 May 2008

Chandra Prakash, Kim Johnson, Clinton Schroeder, and Michael Potchoiba

METABOLISM, DISTRIBUTION AND EXCRETION OF A NEXT GENERATION SELECTIVE ESTROGEN RECEPTOR MODULATOR, LASOFOXIFENE, IN RATS AND MONKEYS
Published May 30, 2008; doi: 10.1124/dmd.108.021808 [Abstract] [PDF]  

Patricia E. Schroeder, Daywin Patel, and Brian B. Hasinoff

The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites
Published May 30, 2008; doi: 10.1124/dmd.108.021626 [Abstract] [PDF]  

Stephan T Stern, Melanie N Tallman, Kristini K. Miles, Joseph K. Ritter, and Philip C. Smith

Androgen Regulation of Renal UGT1A1 in Rats
Published May 30, 2008; doi: 10.1124/dmd.108.020610 [Abstract] [PDF]  

Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa, and Yasuo Ohno

Decreased expression of cytochrome P450s 1A2, 2E1, and 3A4; and drug transporters Na⁺-taurocholate cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients
Published May 30, 2008; doi: 10.1124/dmd.107.020073 [Abstract] [PDF]  

Walter Brand, Petronella A.I. van der Wel, Maarit J. Rein, Denis Barron, Gary Williamson, Peter J. van Bladeren, and Ivonne M.C.M. Rietjens

Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers
Published May 30, 2008; doi: 10.1124/dmd.107.019943 [Abstract] [PDF]  

28 May 2008

Hideo Takakusa, Hiroshi Masumoto, Hideo Yukinaga, Chie Makino, Shintaro Nakayama, Osamu Okazaki, and Kenichi Sudo

Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity
Published May 28, 2008; doi: 10.1124/dmd.108.021725 [Abstract] [PDF]  

27 May 2008

Hirotada Shiratani, Miki Katoh, Miki Nakajima, and Tsuyoshi Yokoi

Species differences in UDP-glucuronosyltransferase activities in mice and rats
Published May 27, 2008; doi: 10.1124/dmd.108.021469 [Abstract] [PDF]  

Vanja Petrovic, Jing-Hung Wang, and Micheline Piquette-Miller

Effect of endotoxin on the expression of placental drug transporters and glyburide disposition in pregnant rats
Published May 27, 2008; doi: 10.1124/dmd.107.019851 [Abstract] [PDF]  

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